Sentences with phrase «rat models of disease»

Not exact matches

Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

«This study, carried out using laboratory rats modeling stroke, demonstrated that ischemic stroke — in both its subacute and chronic stages — damages the BSCB in a variety of ways, creating a toxic environment in the spinal cord that can lead to further disability and exacerbate disease pathology,» said study lead author Dr. Svitlana Garbuzova - Davis, associate professor in USF's Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair.

Within one year a major supplier was offering two different rat models of schizophrenia, two of Alzheimer's, and six of Parkinson's disease — in addition to cancer and other disease models.

A rat model of Parkinson's disease displays increased levels of an inflammatory protein in the colon, identifying a possible new biomarker for the disease (Doris J. M. Doudet, abstract 133.13, see attached summary).

«Previous studies of cardiac microtissues primarily used harvested rat cardiomyocytes, which is an imperfect model for human disease.»

In order to address this, Greka and her colleagues began their investigation with a rare genetic type of kidney disease, and, using a rat model, set out to understand the genes, proteins, and pathways involved in the organ's deterioration.

In a genetic rat model of progressive kidney disease, AC1903 protected the kidney's filtration cells.

The team tested AC1903 in a rat model of kidney disease caused by hypertension and saw the same results: The treatment preserved kidney podocytes and prevented the organs from failing, even in advanced disease.

The cannabinoid receptor agonist WIN 55,212 - 2 reduces D2, but not D1, dopamine receptor - mediated alleviation of akinesia in the reserpine - treated rat model of Parkinson's disease

The objective is to support innovative projects dedicated to the development and the study of rare disease models using small animals (mouse model excepted) such as zebrafish, drosophila, nematode, rat and rabbit.

The CRISPR - Cas technology generates specific animal models of disease and is transforming model generation in mice, rats, rabbits, and larger animals.

Researchers from the group of Gary L. Dunbar at Central Michigan University, Michigan, USA have recently shown the ability of adenovirally generated rat iPSCs to survive and differentiate in the striatum of rats [6], and now in a study in Stem Cells Translational Medicine, they focus on the efficacy of transplantation of these cells into the 3 - nitropropionic acid (3 - NP) rat model of HD [7], which induces cell death by energy - depleting mechanisms providing an accurate model of cell loss and replicates many features of the disease [8].

Impact of L - DOPA treatment on regional cerebral blood flow and metabolism in the basal ganglia in a rat model of Parkinson's disease.

Effects of long - term ethanol administration in a rat total enteral nutrition model of alcoholic liver disease.

Impact of L - DOPA treatment on regional cerebral blood flow and metabolism in the basal ganglia in a rat model of Parkinson's disease % U http://www.sciencedirect.com/science/article/pii/S1053811912002510.

Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson's disease.

The experiments, performed in rat models of Parkinson's disease, reveal that the latest version of stem cell - derived dopamine cells fully mimic the characteristics and function of the dopamine neurons that are lost in Parkinson's disease.

For such study, we have used the McGill - R - Thy1 - APP transgenic rat, which is unique compared to other rodent models in that the AD - like phenotype has been achieved with a single genomic insertion of a mutated human APP transgene; minimizing off - target genetic corruption and therefore being closer to the human disease [32].

Citation: Gamm DM, Wang S, Lu B, Girman S, Holmes T, Bischoff N, et al. (2007) Protection of Visual Functions by Human Neural Progenitors in a Rat Model of Retinal Disease.

Although the mouse remains the most cost - effective choice for comprehensive phenotyping, the rat remains a better model for a number of human conditions, including cardiovascular disease, diabetes and behavioral disorders.

Observations in synapsin knock - out mice that develop epilepsy (Neuroscience 2005, Cereb Cortex 2009b) and in a rat model of ADHD (Neuroscience 2009b) implicate anomalous glutamate signalling in these diseases.

Rat is a key model for cardiovascular disease studies: atherosclerosis, hypertension, stroke models, not only because of its size, but also because of its physiology.

, Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats, 2003

In addition, a study published in «Rejuvenation Research» in 2013 shows that the antioxidant effects of olive leaf extract provide protection against Parkinson's - disease - induced toxic effects in the rat model.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.