Sentences with phrase «rates of a gene variant»

They compared a genetic marker in a population in India (most of which ate meat) to a U.S. population and found higher rates of a gene variant that facilitates the elongation of omega 6 fatty acids.

Not exact matches

Now, to enable widespread gene delivery throughout the central and peripheral nervous systems, Caltech researchers have developed two new variants of a vector based on an adeno - associated virus (AAV): one that can efficiently ferry genetic cargo past the blood - brain barrier; and another that is efficiently picked up by peripheral neurons residing outside the brain and spinal cord, such as those that sense pain and regulate heart rate, respiration, and digestion.

The paper, entitled «Sequence Variants in the RNF212 Gene Associate with Genomewide Recombination Rate,» is published today in the online edition of Science, at www.sciencemag.org/sciencexpress.

However, when we extracted gene expression levels from the brain transcriptome data following the methodology in Carneiro et al. [29], we found that levels of nucleotide diversity and the proportion of low frequency variants between lowly (bottom 5 %) and highly (top 5 %) expressed genes in our dataset (Table S7) were not significantly different in most comparisons (with the exception of π in O. c. cuniculus) nor did they consistently differ in the expected direction when assuming higher error rates in lowly expressed genes.

The two researchers behind the work theorise that if the gene variant were to become globally dominant, it may be able to reduce the rate of alcoholism and health conditions linked to alcohol abuse.

Although next - generation sequencing has revolutionized the ability to associate variants with human diseases, diagnostic rates and development of new therapies are still limited by a lack of knowledge of the functions and pathobiological mechanisms of most genes.