Checkpoint inhibitors already produce unprecedented rates of long - term remission for a handful of hard - to - treat cancers, but their potential is even greater: Because such drugs modify the body's response to cancer,
rather than the cancer itself, they could theoretically be effective against almost any kind of malignancy.
In fact, the Food and Drug Administration's approval of pembrolizumab in May 2017 for adult and pediatric patients with solid tumors and high microsatellite instability, was the first time it had approved a cancer treatment based on a genetic feature
rather than the cancer's location of origin.
Not exact matches
It's the first time the agency has approved a drug that targets
cancer based on a tumor's genetic traits,
rather than where it is located in the body.
The goal is to use a patient's DNA,
rather than a tissue sample, to diagnose
cancer.
This method has proven most effective in blood
cancers (
rather than solid tumors) such as leukemias and lymphomas.
How can businesses offer employees discounted access to services, i.e.,
rather than pay for a set kind of insurance, can they offer a menu of different options for employees, such as pet insurance, a specific kind of medical insurance (like
cancer insurance) or any other possibilities?
A glut of liquid biopsy companies have emerged from universities and elsewhere in recent years to catch
cancer by relying on a patient's DNA,
rather than having to extract their tissue.
With the victims of lung
cancer we have the good sense to respond at the point of human suffering
rather than the point of moral judgment.
What if, for instance, the massive funding for
cancer research in the post-World War II period had been directed toward public health and preventive medicine, including nutrition research,
rather than toward «cures»?
When it comes to making decisions about
cancer treatment, I appear to be what Schwartz would call a «satisficer,» one who is willing to live with the «good enough»
rather than insisting on the «best.»
But he approves of it in the case of a physician who» knowingly facilitated» the suicide of a patient whom he had treated for a long time, knew well, and who had convinced him early on that she preferred to die
rather than go through a long and losing battle with
cancer.
National self - deceit is no less hazardous
than cancer symptoms in a person who decides to ignore the troubling symptoms
rather than to receive appropriate treatment.
The essay «God as Monica's Breast» is worth the price of the volume, and the «Consenting to Die» essay, which discusses suicide and death as something to do»
rather than just wait for, breaks into a fictional discussion between a doctor and a
cancer patient.
Recognizing this, in October 2011 the U.S. Preventive Services Task Force (USPSTF) issued new guidelines recommending that women be tested for cervical
cancer with Pap tests (not HPV tests) every three years
rather than annually because more frequent testing leads to overtreatment of low - grade changes that would in all likelihood not turn out to be cancerous.
Some, mainly men,
rather than women, are too scared to see a doctor if they suspect they have a serious disease, even
cancer.
WOODSTOCK — With the shift in efforts of the war on
cancer to prevention,
rather than cure (Tribune, March 30), information regarding the relationship between reduced risks of breast
cancer and breastfeeding should be included in efforts of prevention.
With the shift in efforts of the war on
cancer to prevention,
rather than cure (Tribune, March 30), information regarding the relationship between reduced risks of breast
cancer and breastfeeding should be included in efforts of prevention.
Rather than posting what color your bra is or where you «like it» why not post something informative like this study which shows that breastfeeding for at least 2 years lowers the typical woman's breast
cancer risk by 50 %?
Eventually, what started out as an investigation about symptoms like sneezing and watery eyes, may lead to the determination of a fatal disease or incurable
cancer,
rather than what is really just a mild allergic reaction.
State Attorney General Eric Schneiderman has reached a settlement with what he termed a «shell» breast
cancer charity that was raising lots of money but keeping 92 percent of the proceeds
rather than administering medical care.
Akeredolu who led a delegation of Breast
Cancer Association of Nigeria (BRECAN) to visit the Lagos state Governor, Mr. Akinwumi Ambode, said
rather than seeking medical help such people go from one prayer house to the other for solution to their problem.
He said he'd
rather put his faith in the F.D.A. or the Memorial Sloan - Kettering
Cancer Center, where he receives treatment, than the state health department when it comes to determining if medical marijuana will actually benefit cancer pat
Cancer Center, where he receives treatment,
than the state health department when it comes to determining if medical marijuana will actually benefit
cancer pat
cancer patients.
I watched my mother die from
cancer three years ago and had often had philosophical discussions with her prior to her becoming ill about how she would
rather die
than become so ill that her family had to care for her.
Cancer Research UK (CRUK), which is funded by donors
rather than public money, said it could not be expected to fill the gap.
Although long - debated in California, the issue of physician - assisted death gained momentum after Brittany Maynard, a 29 - year - old Californian who was terminally ill, decided to move to Oregon in 2014 to end her life
rather than suffer the pain and debilitation caused by brain
cancer.
Rather than pack up and go home, he went for the last option available — a master's degree in
cancer research — and picked a
cancer lab that also studied viruses, at the University's Institute of Hematology.
PARP inhibitors prevent DNA repair causing
cancer cells to die
rather than repair.
According to Maley, one hopeful approach would be to use
cancer's evolveability to advantage,
rather than attempt to fight it head on.
We are currently in the process of developing a nose structure for a patient whose nose has been lost though
cancer, using a resorbable plate mesh,
rather than titanium which needs to be removed after.»
Strengths of this study, Dr. Li noted, included that researchers used an objective measuring device and studied a short - term outcome (miscarriage)
rather than one that will occur years or decades later, such as
cancer or autoimmune diseases.
Results from a 2006 study in Ireland and the U.S. suggest that patients who undergo surgery to remove breast or prostate
cancer might be less prone to recurrence if they are administered regional anesthesia during their procedures,
rather than general anesthesia alone.
Active surveillance involves regular testing to check for
cancer growth
rather than immediate treatment, and many patients with low - risk prostate
cancer on active surveillance may be able to avoid treatment for several years or altogether.
Most of the 580,000 U.S.
cancer deaths each year are caused by complications from the spread of
cancer to distant tissues and organs,
rather than from the primary tumor itself.
The study also suggests that targeting the machinery that makes cells mobile,
rather than targeting the tissue - clearing process — which has been tested in patients but has not been very effective — may be a better treatment strategy to stop
cancers from spreading.
But T - cells appear to be even more promising, because they can react to abnormalities inside
cancer cells
rather than just on their surfaces.
The team led by Andreas Plückthun, Director of the Department of Biochemistry at the University of Zurich, involving postdoc Rastik Tamaskovic and PhD student Martin Schwill, has now found out why these antibodies merely slow tumor growth
rather than killing off the
cancer cells.
This is how treatments based on a type of white blood cell called T - cells are curing some
cancers,
rather than just slowing their advance (see «
Cancer meets its nemesis in reprogrammed blood cells «-RRB-.
Pancreatic
cancer is the only
cancer for which deaths are predicted to increase in men and women
rather than decrease in 2014 and beyond, according to a comprehensive study published in the leading
cancer journal Annals of Oncology.
But
rather than writing off
cancer immunotherapy, some researchers argue that the agents have been examined in the wrong way, resulting in erroneous conclusions.
«We urgently need new treatments for lung
cancer patients, and this research suggests we can boost the effectiveness of an existing drug,
rather than switch to another new expensive treatment.
Cancer is often talked about in terms of years in remission rather than cure because there is still the creeping concern that the cancer will one day resu
Cancer is often talked about in terms of years in remission
rather than cure because there is still the creeping concern that the
cancer will one day resu
cancer will one day resurface.
Many
cancers get energy from glycolysis, which occurs in the liquid inside cells,
rather than via aerobic respiration from mitochondria.
That makes sense, Swanton says, because if the immune system targets trunk antigens, it's hitting most of the
cancer cells,
rather than «nipping off little branches».
All
cancers are products of natural selection played out on the level of cells
rather than species.
Rather than getting heart disease or
cancer in our fifties or sixties and needing expensive treatments and drugs to keep us alive (if they do) until we're 75, we will age more slowly.
Why is formaldehyde still listed by the EPA as a probable
rather than a known carcinogen, despite major scientific research linking it to leukemia and other forms of
cancer?
«It may be the treatments used for migraines that are responsible for this risk reduction
rather than the migraine itself,» says study co-author Christopher Li, a
cancer epidemiologist at Fred Hutchinson Cancer Research Center in Se
cancer epidemiologist at Fred Hutchinson
Cancer Research Center in Se
Cancer Research Center in Seattle.
The study by the University of Southern California «exemplifies a real opportunity for the oncology community, one that embraces an integrated approach to understanding
cancer progression and developing therapies that exploit evolution
rather than ignore it,» said Anderson.
«This is a treatment that,
rather than targeting
cancer cells themselves, targets the immune response, reactivating the T cells in the neighborhood of the tumor cells,» Shipp remarked.
Rather than relegating PSA into oblivion, the balanced answer may be best found in the more intelligent use of available tools, implementation of shared decision making as recommended by the American
Cancer Society, and development of more effective screening techniques.»