More to the point, by genetically stripping dengue virus of its ability to bind 14 -3-3 epsilon, Gack has generated a crippled virus that can elicit a strong human immune response, providing a framework for
rational vaccine design against emerging infectious diseases.
«We think we can use our molecular,
rational design approaches to make a better flu
vaccine for people who really need it,» says study leader Andrew Pekosz, PhD, an associate professor in the Department of Molecular Microbiology and Immunology at the Bloomberg School of Public Health.