Sentences with phrase «reactivated in cancer cells»

The protein is normally active in fetal tissue and switched off in adults, but it is reactivated in some cancer cells.

«We think that these genes, which are normally only expressed in the placenta to facilitate invasion, are becoming reactivated in cancer cells and supporting invasion in this context too,» she says.

Not exact matches

Davies and Lineweaver suggest that genes active in embryogenesis and switched off later may be reactivated because of damage, causing the accelerated cell division of these rogue cancer cells.

«This is a treatment that, rather than targeting cancer cells themselves, targets the immune response, reactivating the T cells in the neighborhood of the tumor cells,» Shipp remarked.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study published June 18th in the journal Cell.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

The results show that generation of an optimal immune response to cancer requires cooperation between two types of memory T cell — one circulating in the blood and the other resident in tissues — that can be reactivated with current immunotherapy strategies.

In this way they were able to reactivate the senescence program and stop the growth of the breast cancer cells.

Telomerase is turned off in most human cells, but cancer cells often must reactivate it so that they can keep dividing like crazy.

Freshly isolated tumor - infiltrating T cells are usually inactive against autologous cancer cells but can be reactivated in - vitro by the addition of IL - 2 191.

Furthermore, the hedgehog pathway, a reactivated embryonic pathway in cancer cells, was reported as pyrvinium - sensitive signal transduction mechanism [65].

«We are seeing the immune system developing memory, which then reactivates to kill future cancer cells,» Chung said, referring to the ongoing positive response in patients successfully treated with immunotherapy.