Reactivated latent infections may result in relapsing or persistent viremia with shedding of virus in the saliva.
GFP - positive cells, indicative of
reactivated latent HIV - 1, were isolated by fluorescence activated cell sorting (FACS).
The combined use of therapeutic vaccination and specific drugs that can
reactivate latent reservoir virus (Kick and kill strategies) hold the promise to achieve a functional cure for HIV infection.
Our findings may prove useful in the development of novel therapies to efficiently
reactivate latent HIV - 1, thus making it susceptible to current drug therapies.
Furthermore, we demonstrate that a drug that inhibits DNA methylation potently
reactivates latent HIV.
Aza - CdR and HDAC inhibitors do not synergistically
reactivate latent HIV - 1 Latent HIV - 1 reactivation in the indicated J - Lat cell lines treated with aza - CdR, VPA, aza - CdR plus VPA, SAHA, or aza - CdR plus SAHA.
«If we can
reactivate latent EBV in tumors, then we can also specifically target those tumors with our own immune systems or antiviral drugs,» said Miranda.
Previous research has had limited success in efficiently
reactivating latent HIV, so scientists are working to find new, more effective drugs.
They discovered that increasing the random activity, or noise, associated with HIV gene expression — without increasing the average level of gene expression — can
reactivate latent HIV.
Stress can also
reactivate latent infections — people who get cold sores know this from experience.
According to one curator, Carol Bove's» «settings» draw on the style, and substance, of certain time - specific materials to resuscitate their referential possibilities, to pull them out of historical stasis and return them to active symbolic duty, where new adjacencies might
reactivate latent meanings.»
«Bove's «settings» draw on the style, and substance, of certain time - specific materials to resuscitate their referential possibilities, to pull them out of historical stasis and return them to active symbolic duty, where new adjacencies might
reactivate latent meanings.»
Not exact matches
Other common
latent viruses could be more uncomfortable if they
reactivated on a trip to Mars — chicken pox, for example, which usually returns as shingles.
After initial infection, HSV enters a
latent state in sensory nerve cells, periodically
reactivating to produce disease.
In the new study, expanding upon what scientists previously understood about intrinsic immunity, the researchers found that cells can subsequently respond to
latent HCMV by employing other cellular proteins called lysine demethylases to
reactivate the virus.
In the United States, tuberculosis remains an important preventable disease, including active tuberculosis infection, which may be infectious, and
latent infection (LTBI), which is asymptomatic and not infectious but can later
reactivate and progress to active disease.
Researchers are exploring two main strategies to tackle this problem ----
reactivate and destroy the
latent virus (called «shock and kill») or find a way to silence it for good.
«Then we can ask: Does a mouse have similar pathways, and can it
reactivate dormant abilities that are perhaps
latent in its genome?»
When the virus «hiding» in
latent T cells is
reactivated, it can spread again.
«We identified SMYD2 as a regulating enzyme, and found that inhibiting it
reactivates, or wakes up,
latent cells.
What's more, Rose writes, «the results have exciting implications if noninvasive brain stimulation techniques can be used to
reactivate and potentially strengthen
latent memories» — in other words, recovering information that had been forever lost.
Latent infections may be
reactivated by: stress, immunosuppressive therapy, complement depletion, and serious concurrent disease.
This virus can remain
latent for many months and be
reactivated by stress or an immunosuppressive agent such as a shot of cortisone or similar steroid.
Encapsulated virus (like feline rhinotracheitis virus), opportunistic and low immunogenic activity, with tropism for both respiratory and genital mucous membranes and central nervous system, capable of persisting in a
latent status and
reactivating at regular intervals.