Sentences with phrase «reactivates cells»

They found 204 that reactivated cell proliferation, including two that affected nearly 2000 genes.

After reactivating the cells with an electric shock, the group grew several oocytes in culture to the blastocyst stage.

The «kick - and - kill» paradigm is aimed at combining latency reversing agents (LRA) with immune effectors, such as T - cells, to wake up the virus and kill the reactivated cells.

Mayford could then selectively reactivate those cells whenever he wanted, simply by giving the mouse a drug known as clozapine - N - oxide (CNO), which interacts with hM3Dq.

Not exact matches

Davies and Lineweaver suggest that genes active in embryogenesis and switched off later may be reactivated because of damage, causing the accelerated cell division of these rogue cancer cells.

Clamping the cord, especially at an early stage, may also cause the extra blood trapped within the placenta to be forced back through the placenta into the mothers blood supply with the third stage contractions.32 33 This feto - maternal haemorrhage (FMH) increases the chance of future blood group incompatibility problems, which occur when the current baby's blood enters the mother's blood stream, causing an immune reaction which can be reactivated in a subsequent pregnancy, destroying the baby's blood cells and causing anaemia or even death.

In leukemia cells it is often the case that genes are reactivated that, in physiological terms, mediate the self - renewal of blood stem cells.

Scientists examined the DEJ for T cell activity because this is where the genital herpes virus multiplies after reactivating and traveling from its hiding place in the body's sensory neurons.

«We think that these genes, which are normally only expressed in the placenta to facilitate invasion, are becoming reactivated in cancer cells and supporting invasion in this context too,» she says.

By analysing the early steps that precede tumor formation, Alexandra Van Keymeulen and colleagues found that expression of oncogenic Pik3ca reactivates a multilineage differentiation program in adult stem cells that resembles to an immature embryonic state.

Although de Lange notes that telomere shortening needs further investigation, she says there's now no doubt that telomeres play a critical role in limiting human cell division and that telomerase can reactivate the process.

«At first we were surprised by how rapidly NR was able to reactivate dormant mitochondria in muscle, despite being largely consumed by other cell types,» Frederick said.

By reactivating telomerase activity in stem - cell derived tissue transplants, Geron could provide patients with a life - time warranty on their new parts.

We also reactivated insulin production in human pancreatic cells from type 1 diabetes patients.»

«This is a treatment that, rather than targeting cancer cells themselves, targets the immune response, reactivating the T cells in the neighborhood of the tumor cells,» Shipp remarked.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study published June 18th in the journal Cell.

«The effect of the precursors that boost NAD is to counteract the decline that occurs with normal aging, to reactivate SIRT1, and to restore function in endothelial cells to give rise to more blood vessels.»

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

The authors report that when the inactive halves of DAM attached to Notch and its partners rejoined, they reactivated and allowed the marking of the bound DNA in kidney cells.

A study published by Cell Press November 7th in the journal Cell has revealed that an evolutionarily conserved gene called Lin28a, which is very active in embryos but not in adults, enhances tissue repair after injury when reactivated in adult mice.

These cells had previously been shown to reactivate estrogen signaling in order to acquire drug resistance.

After initial infection, HSV enters a latent state in sensory nerve cells, periodically reactivating to produce disease.

I read with interest your article on so - called sleeper cells — bacteria that become dormant to survive antibiotics, reactivating when...

«Once a liver cell is infected, the viral genome persists inside the nucleus, and that can reactivate later,» says Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science.

In the new study, expanding upon what scientists previously understood about intrinsic immunity, the researchers found that cells can subsequently respond to latent HCMV by employing other cellular proteins called lysine demethylases to reactivate the virus.

G2 - arrested quiescent stem cells reactivate more readily than G0 cells and are regulated by the pseudokinase Tribbles.

But even with HAART, HIV can linger in brain and immune cells, reactivating years later to cause heart, kidney and neurological problems.

As a result, the cells would start to become partially reactivated, growing rapidly and beginning to resemble cancer cells.

When a latently infected cell is reactivated, the cell begins to produce HIV again.

The protein is normally active in fetal tissue and switched off in adults, but it is reactivated in some cancer cells.

Both memory T cells subtypes can be reactivated with current immunotherapy treatments, and reactivation of both requires DC1 dendritic cells.

Moreover, the efficiency of immunotherapy was further increased by combining this adoptive transfer with the current clinical strategy of reactivating the T cell antitumor response with antibodies to the receptor PD - 1.

Tissue - resident memory cells generate an alert state that attracts and reactivates the circulating memory cells, resulting in a faster and more effective immune response.»

The results show that generation of an optimal immune response to cancer requires cooperation between two types of memory T cell — one circulating in the blood and the other resident in tissues — that can be reactivated with current immunotherapy strategies.

The results, which appear November 7 in Cell, suggest that reactivating Lin28a, along with other techniques, help could help adult humans heal more quickly after an injury.

They do this by reactivating dormant genes associated with pluripotency — a primitive state in which a cell has the potential to become any cell type in the body.

This enables scientists to genetically modify phage genomes systematically, provide them with additional functionality, and finally reactivate them in a bacterial «surrogate» — a cell - wall deficient Listeria cell, or L - form.

Aza - CdR and HDAC inhibitors do not synergistically reactivate latent HIV - 1 Latent HIV - 1 reactivation in the indicated J - Lat cell lines treated with aza - CdR, VPA, aza - CdR plus VPA, SAHA, or aza - CdR plus SAHA.

In this way they were able to reactivate the senescence program and stop the growth of the breast cancer cells.

The researchers found that the oral drug, deferiprone, like the topical anti-fungal medicine ciclopirox that they previously studied, reactivates the «altruistic suicide response» of an HIV - infected cell, killing the HIV DNA it carries.

GFP - positive cells, indicative of reactivated latent HIV - 1, were isolated by fluorescence activated cell sorting (FACS).

When the engram cells were reactivated with light in the AD mice, memory of the footshock experience became retrievable and freezing behavior was restored.

Telomerase is turned off in most human cells, but cancer cells often must reactivate it so that they can keep dividing like crazy.

In cancerous cells, telomerase somehow becomes reactivated, and the telomeres begin growing again.

«Now, with the help of gene therapy and stem cells we can help reactivate the body's response to hypoxia and save limbs.»

A drug that could reactivate p14 ARF would reactivate p53, thereby reinvigorating the cell's defenses.

Freshly isolated tumor - infiltrating T cells are usually inactive against autologous cancer cells but can be reactivated in - vitro by the addition of IL - 2 191.

Knox developed a chemical compound that can be injected into the gland to mimic the signals from the nerve cells and reactivate the repair process with the stem cells.

Furthermore, the hedgehog pathway, a reactivated embryonic pathway in cancer cells, was reported as pyrvinium - sensitive signal transduction mechanism [65].

But it turns out that a process called somatic cell nuclear transfer (SCNT) can sometimes reactivate genes.