Sentences with phrase «reactive t»

Iodinated thyroglobulin is more antigenic because T cells that pass thymic selection, the process whereby self - reactive T cells are deleted, only recognize non-iodinated thyroglobulin motifs as belonging to self (22).

We sequenced T - cell receptor Vβ genes in expanded microbe - reactive T - cell lines to determine their clonal diversity.

Areas of focus include: understanding how tumour - reactive T cells and B cells promote patient survival in cancer; defining the effects of standard treatments on tumor immunity; and using genomic approaches to identify novel tumour mutations that can serve as target antigens for immunotherapy.

We also assessed their functional phenotypes and effects on intestinal resident cell populations, and studied alterations in microbe - reactive T cells in patients with chronic intestinal inflammation.

Recent studies indicated that autoimmune diseases like Type 1 Diabetes (T1D) are induced by genetic or environment - induced alterations of immune regulatory pathways whose function is to avoid or limit the activation / expansion of self - reactive T lymphocytes.

Trautmann L, Labarrière N, Jotereau F, Karanikas V, Gervois N, Connerotte T, Coulie P, Bonneville M. Dominant TCR Va usage by virus and tumor reactive T cells with wide affinity ranges for their specific antigens.

LA JOLLA, CA — Multiple sclerosis, a debilitating neurological disease, is triggered by self - reactive T cells that successfully infiltrate the brain and spinal cord where they launch an aggressive autoimmune attack against myelin, the fatty substance that surrounds and insulates nerve fibers.

Moreover, VPA treatment might add another beneficial layer of anti-leukemia effect, because a recently published study showed that inhibition of Akt signaling promoted the generation of leukemia - reactive T cells (56).

Restifo and colleagues have shown that mature, highly reactive T cells tend not to persist very long in the body.

In late 2013, he published what seemed to be a breakthrough study of patients with narcolepsy, which identified self - reactive T - cells that pursued the hormone hypocretin.

Arming Tumor - Reactive T Cells with Costimulator B7 - 1 Enhances Therapeutic Efficacy of the T Cells

«It has long been a question whether we'd even be able to detect sufficiently mutation - reactive T cells in patients with tumors that have low mutational loads.»

We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor - reactive T cells directed against overexpressed self - derived differentiation antigens after a nonmyeloablative conditioning regimen.

Instead, the body seems to keep these so - called self - reactive T cells in benign form to fight potential invaders later.

Some researchers think the new findings could shift the field's view on how the body handles self - reactive T cells.

The people who are missing a functional Aire gene lack the ability to delete self - reactive T - cells.

These results suggest GSK2636771 treatment can «synergize» with OX40 agonist antibodies to augment effector functions of tumor - reactive T cells.»

Not exact matches

According to a report in The National Interest from Dave Majumdar (Click Here for Story), Russian T - 14s are engineered with an unmanned turret, reactive armor and Active Protection Systems.

He fits Reactive Attachment Disorder to a perfect T. His diagnosis is going to be removed now (tested today and that's the idea I was told).

Half of the patients that could be evaluated showed big increases in the numbers of T - cells specifically reactive to tumor material, indicating a good response to vaccination.

People who have a mutation in the Autoimmune Regulator, or Aire, gene can not destroy T - cells that are «self - reactive.»

Therefore, these «self - reactive» T cells survive destruction within an organ called the thymus, the central immune organ in which T - cells mature, and attack healthy cells and tissues, including melanocytes.

It is caused by the Epstein - Barr virus (EBV), which infects B cells (B - lymphocytes), producing a reactive lymphocytosis and the atypical T cells (T - lymphocytes).

Led by Ludwig Lausanne investigator Alexandre Harari and George Coukos, director of the Ludwig Institute for Cancer Research, Lausanne, the study shows that ovarian tumors harbor highly reactive killer T cells — which kill infected and cancerous cells — and demonstrates how they can be identified and selectively grown for use in personalized, cell - based immunotherapies.

One of these T cell subsets is comprised of the CD1d - reactive invariant natural killer T cells, and over the years we have studied the development, homeostasis, activation and regulation of function of these cells, as well as their specificity and the pathways leading to the processing and presentation of antigens by CD1d.

Smaller subsets of T cells are reactive toward various nonpeptidic ligands associated with nonpolymorphic MHC class - Ib (MHC - Ib) molecules.

In general, immunotherapy tweaks T - cells, white blood cells that recognise and kill invaders, to be more reactive to cancer cells.

Activation and tolerance in CD4 + T cells reactive to an immunoglobulin variable region.

Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein - reactive CD4 + T cells compared.

T - cell subsets as well as the inflammatory markers IL - 6, IL - 10, C - reactive protein, transthyretin and albumin were evaluated.

Matsuzaki J, Qian F, Luescher I, Lele S, Ritter G, Shrikant PA, Gnjatic S, Old LJ, Odunsi K. (2008) Recognition of naturally processed and ovarian cancer reactive CD8 + T cell epitopes within a promiscuous HLA class II T - helper region of NY - ESO - 1.

We used 2 independent assays (CD154 detection and carboxy - fluorescein succinimidyl ester dilution assays) and 9 intestinal bacterial species (Escherichia coli, Lactobacillus acidophilus, Bifidobacterium animalis subsp lactis, Faecalibacterium prausnitzii, Bacteroides vulgatus, Roseburia intestinalis, Ruminococcus obeum, Salmonella typhimurium, and Clostridium difficile) to quantify, expand, and characterize microbe - reactive CD4 + T cells.

In patients with inflammatory bowel diseases, microbiota - reactive CD4 + T cells were reduced in the blood compared with intestine; T - cell responses that we detected had an increased frequency of interleukin 17A production compared with responses of T cells from blood or intestinal tissues of controls.

We examined the effects of microbe - reactive CD4 + T cells on intestinal stromal and epithelial cell lines.

Measures utilized were the Behavior Assessment System for Children — Teacher Rating Scale (BASC - TRS), the teacher Report of Reactive and Proactive Aggression, and the Antisocial Process Screening Device — Teacher Form (APSD - T).

Measures utilized were the Behavior Assessment System for Children — Teacher Rating Scale (BASC - TRS), the Teacher Report of Reactive and Proactive Aggression, and the Antisocial Process Screening Device — Teacher Form (APSD - T).