Sentences with phrase «reactive lysines»

Having made this proof - of - principle demonstration, Cravatt and colleagues now plan a broader effort to discover small molecules that bind covalently to reactive lysines.

As expected, the scientists found that these hyper - reactive lysines were unusually likely to be located at functional sites on proteins.

In another experiment, a more direct test of druggability, the researchers used a library of small molecules — broadly representing potential drug molecules — to see which could compete with the probe in binding covalently to reactive lysines on human proteins.

For example, in the case of the protein SIN3A, a regulator of gene transcription, the small molecule that covalently binds to its reactive lysine blocks the protein's function by disrupting SIN3A's interaction with another protein, TGIF1 — an interaction implicated in some invasive breast cancers.

Not exact matches

Of these lysines, 310 met criteria for being abnormally reactive.

Ascorbate (vitamin C) is a reducing sugar (has a reactive ene - diol structure) that is involved in biochemical processes, such as hydroxylation of proline and lysine utilized in the formation of collagen and healthy connective tissue.