ROS and
reactive nitrogen species (RNS) are collectively called RONS.
The mitochondria in our cells are responsible for releasing energy from the molecules in our food, but they also unleash electron - stealing free radicals like reactive oxygen and
reactive nitrogen species.
Intracellular oxidative stress arises due to the imbalance in the production of reactive oxygen /
reactive nitrogen species and cellular antioxidant defense mechanisms.
Intense exercise also upregulates nitric oxide production by 600 % which can further produce
reactive nitrogen species.
We used the gamma tocopherol form because not only does it have antioxidant activity, like alpha tocopherol, but recent evidence indicates that it also has effective ability to lower inflammation and also trap what we call
reactive nitrogen species.
These powerhouse organelles are major sites of oxidative stress due to the high production of reactive oxygen species ROS (reactive oxygen species) and RNS (
reactive nitrogen species).
One of the key processes involved in secondary damage is iNOS (Nitric oxide synthase)- mediated cell damage, through the generation of
reactive nitrogen species peroxinitrates.
So where are
these reactive nitrogen species coming from?
Not exact matches
Free radicals like
reactive oxygen and
nitrogen species (ROS, RNS) are molecules missing an electron, making them highly unstable and capable of destructive interactions with lipids, DNA, and proteins.
Free radicals are released by cellular mechanisms responding to impact and cardio - muscular stress - specifically
reactive oxygen and
nitrogen species (RONS).
Bodamyali, T.; Stevens, C. R.; Blake, D. R.; Winyard, P. G.
Reactive oxygen /
nitrogen species and acute inflammation: a physiological process.
Moreover,
reactive nitrogen and oxygen
species (RNOS) are used extensively in cellular signalling, and cells adaptively regulate endogenous antioxidants on short time scales to respond to deletorious spikes of RNOS faster than we could ever achieve with dietary antioxidants.
Similarly, a problem with antioxidant production can result in the buildup of
reactive oxygen and
nitrogen species, otherwise termed «free radicals», in the mitochondria.