Sentences with phrase «reactive thiols»
Not exact matches
Based on this method of compound activity classification, we identified a class of thiol - reactive (electrophilic) HMOX1 inducing compounds, exemplified by HPP - 1014.
http://journals.plos.org/
In NHLF cells transfected with siRNA against Nrf2 and subsequently treated with either the thiol - reactive compounds CDDO - Me or HPP - 1014; or the non-reactive compounds CoPP or HPP - 4382, there was a marked reduction in HMOX1 expression.
Thiol - reactive electrophilic compounds often increase ROS levels in cells, as a consequence of their ability to deplete glutathione.
The thiol is the major reactive site within the amino acid, cysteine, which is ubiquitous in biochemically active proteins such as enzymes.