The team employed a new, massively parallel technique called pyrosequencing, which uses pulses of light to
read the sequence of thousands of bases at once.
Basically, the cell's protein - making machinery
reads a sequence of DNA as a sentence composed entirely of three - letter words called codons.
Our cells
read the sequence of chemical letters in DNA to make proteins, and the DNA corresponding to one protein is called a gene.
Not exact matches
We may be pulling a fanboy move and
reading into it too much, but the use
of the word «
sequence» and Nolan's desire to show off the format leads us to believe you'll get an action - packed clip.
If you want to
read more about it, Peter Kafka at Re / code and Farhad Manjoo at the New York Times have both looked at the
sequence of events that led to Gigaom's demise.
The commercialization
of DNA
sequencing (the
reading of an organism's code) and synthesis (the writing
of that code) has accelerated since the mapping
of the human genome was completed in 2003.
The Greedometer
sequence is sufficiently mature that a major new dose
of monetary policy candy is going to be required to -LSB-...]
Read the rest
of this entry»
Over the past six months, I've been
reading a stream
of research papers that illustrate how accessible genomic
sequencing is transforming our knowledge
of genetic traits, our ability to treat according to genetic diagnosis, and challenge the status quo on how individuals benefit from genetics.
It can be captured not in a single principle but only in a
sequence of images that are embedded in that story, focus our
reading of it and provide a framework within which individual texts can make sense.
In fact if you actually
read the olkd testiment and specifially Genesis, you will find that sciences account
of how the earth was formed and how the animals evolved follows the
sequence exactly.
With all due respect, if you'd
read the actual study, you would see that this was not a whole genome
sequence comparison; rather it was a comparison
of mitochondrial 12S rDNA and 16S rDNA
sequences for the purposes
of confirming the species relationship between the Pod Mrcaru lizards (P. sicula), the source population from Pod Kopiste (also P. sicula), and the original indigenous population on Pod Mrcaru (P. mellisellensis).
They are
reading the book
of Revelation, from chapter 19, verse 11, to the end
of chapter 20, a
sequence of apocalyptic visions, as if they were prophecies.
You draw your own conclusions on the strength
of a fresh, contemplative
reading of the four Songs in immediate
sequence.
In this respect, I
read this book as I
read any other great book: I assume that every word counts; I attend especially carefully to the
sequence and the local context, in the belief that the meaning
of each part is dependent partly on what comes before and after, both immediately and also remotely.
You want to let the story
of Jonah tell you what the author is trying to say, and the only way to do this is by
reading the story in context and
reading the story in
sequence.
Watford's away form
reads W3 D1 L2 this season and despite having lost their last two road games at Everton and Chelsea, they have maintained their
sequence of having scored exactly two goals in each
of their away games this season which is pretty remarkable.
Boro's away form this season
reads W1 D7 L9 and the lone win in that
sequence came in their first away game
of the season back in August.
This was such a fun and easy activity for me to set up, and they got such enjoyment out
of it while also incorporating practice in
reading, problem solving, measuring, weighing, following instructions, fine motor skills,
sequencing, counting, fractions, turn taking, communication, and probably much more!
Stool samples were dominated by Bacteroides and Bifidobacterium comprising half
of sequence reads, with Streptococcus, Clostridium, Enterococcus, Blautia, Veillonella, Lactobacillus, Staphylococcus, Planococcus, and others representing the remainder (Table 2).
Sequencing yielded a total
of 14362739 bacterial DNA
reads (mean, 140811; range, 27 897 - 260579),
of which 8210402 (mean, 80494; range, 12 244 - 178802) passed quality filters (eAppendix in the Supplement).
As you
read it for a second (or more) time, talk about the
sequence of events and what will happen next.
Now that all three volumes
of Mullin's diaries are published, it's advisable to
read them in
sequence — they will provide historians with as much
of a valuable insight into New Labour as into the diarist himself.
In the Originating Summons marked FHC / ABJ / CS / 232/2018, the plaintiff 8 issues for determination by the court, including: Having regards to the combined provisions
of sections 79,116,118,132,153,160 (1) and 178
of the 1999 constitution as amended, the constitution
read together with paragraph 15 (a)
of the third schedule to the same constitution, whether the 3rd defendant (Independent National Electoral Commission) is not the only institution or body constitutionally vested with the powers and vires to organized, undertake and supervised elections to the offices
of the president, the vice president
of the federal republic
of Nigeria, the Governor and deputy governor
of a state, the membership
of the Senate, the House
of Representatives and the House
of Assembly
of each state
of the federation, including fixing the
sequence and dates
of the elections to the said offices?
I remember looking at the report and realizing that there were all
of these similar genes in all
of these different animals and thinking: «Maybe a careful
reading of the papers associated with the
sequences most similar to mine will tell me something about my own gene.»
The open
reading frame
of the
sequenced clone coded for 97 amino acids, including the known amino acid
sequence of this polypeptide.
«For chloroplast genome recovery from total DNA
sequence data, the deliberate identification
of reads that represent chloroplast DNA inserts into the nuclear genome allowed us to attain a higher - quality chloroplast genome assembly in a time - and cost - effective way,» Garaycochea explains.
«It's a lot like
reading a book, but in this case, the final chapter
of the book — or the final exon
of the genetic
sequence — is omitted.
Until now, such large - scale data storage has been impractical because
of the difficulty and cost
of reading and writing long
sequences of DNA.
The new study, led by Johannes Krause, a geneticist at the Max Planck Institute for the Science
of Human History in Jena, Germany, used next - generation
sequencing methods to
read stretches
of any DNA present in a sample and fish out those that resembled human DNA.
In one
of their most challenging human DNA projects to date — no British individual this old has ever had their genome
sequenced — the Natural History Museum's ancient DNA lab's Professor Ian Barnes and Dr Selina Brace carried out the first ever full
reading of Cheddar Man's DNA.
As an undergraduate studying genome sciences at the National Autonomous University
of Mexico, she was immediately fascinated when she
read some
of the early papers about
sequencing Neandertal mitochondrial DNA.
Thanks to PCR, scientists could amplify DNA in great volumes and thereby «
read» the genetic
sequences of all sorts
of organisms in all their variations.
Uniform alignments
of sequence reads, corresponding to on - target and off - target in vitro cleavage sites, were computationally identified.
But short
reads can be hard to interpret during the overlaying process and there hasn't been a way to
sequence long fragments
of DNA in a targeted and more efficient way.
By
reading the complete DNA
sequence of the TB bacterium from each patient in an outbreak, her group showed that it was possible to determine who likely infected whom in the outbreak.
Powerful computational approaches and infrastructure are required to
read and compare
sequences of billions
of DNA base pairs.
Researchers have demonstrated for the first time that they can continuously
read the chemical letters
of DNA as it travels through a tiny pore, paving the way for a new kind
of sequencing machine that decodes DNA much like an announcer
reading a ticker tape.
First, they are never oncogenes; and second, the genes seem to be
read normally whether or not a foreign
sequence has jumped in alongside them, which means that there is little danger
of disrupting vital physiological processes.
The genome
of Picea abies, one
of the largest ever
sequenced, appears May 22 in Nature and is one
of several that have been
read out recently from trees known as gymnosperms — seed - bearing plants that don't produce flowers.
Given a large enough sample
of DNA, the
sequencing machines could not only
read the lettering
of a gene but could also distinguish a healthy gene from one with a harmful mutation — a disease gene.
One
sequencing technology used by the researchers produces massive amounts
of very short
reads — about 150 to 250 bases in length.
The Y chromosome, like all DNA, is composed
of a series
of molecules called «bases» that are represented by the letters A, T, C, and G. Current genetic
sequencing technologies produce «
reads»
of sequence that are much shorter than the entire length
of the chromosome.
The single - cell technique is better at detecting subtle mosaicism than usual DNA
sequencing methods, which
sequence many thousands or millions
of cells mixed together and
read out an average for the sample.
Using this method, the researchers
sequenced enough
reads to cover the entire length
of the Y chromosome about 450 times.
«By reducing non-Y chromosome
reads from our data with flow sorting and the RecoverY technique that we developed, and by using this combination
of sequencing technologies, we were able to assemble the gorilla Y chromosome so that more than half
of the
sequence data was in chunks longer than about 100,000 bases in length,» said Medvedev.
Many
of these repeats, including some genes, appear as back - to - back series
of the same repeated
sequence or as long palindromes which, like the word «racecar,»
read the same forward and backward.
Sequencing nuclear genomes requires sequencing the DNA library many times over, increasing the «depth» of sequence reads at
Sequencing nuclear genomes requires
sequencing the DNA library many times over, increasing the «depth» of sequence reads at
sequencing the DNA library many times over, increasing the «depth»
of sequence reads at each base.
He is a pioneer
of genome
sequencing, but Harvard University's George Church wants to do more than
read DNA.
Also, in the»80s, genotyping [
reading DNA's
sequence of letters] was really expensive.
So when Page's team started
sequencing the chromosome, they expected to find a gene - free runt or a genetic jungle whose
sequence would consist mostly
of repetitive, difficult - to -
read gobbledygook.