Sentences with phrase «reading frame»

Therefore, mutation (s) in alternate reading frame protein dysregulate p53 function and play a role in tumor immune evasion.

Upon further investigation, they found that a tumour - suppressor gene called alternative reading frame (ARF), which is normally suppressed in mouse and human iPSCs, remained active in the mole - rat iPSCs.

Alternate reading frame protein (ARF) complexes with mouse double minute 2 homolog 2 (MDM2), an E3 ubiquitin ligase that regulates the stability of p53 and therefore suppressing tumor growth, it is also involved in the immune response, by modulating the tumor environment [46].

In combination with the C1388del, however, the G1466T substitutions results in an additional stop codon at amino acid position 489 within the shifted reading frame (Gly489X).

Translation then switches from the defective message to a short open reading frame on tmRNA that tags the defective nascent peptide chain for degradation.

An out - of - frame overlapping reading frame in the ataxin - 1 coding sequence encodes a novel ataxin - 1 interacting protein.

TGTT in exon 12 of NPM1 gene that may impact the normal reading frame.

The flavivirus genome, approximately 10.5 kb in size, encodes three structural proteins [capsid (C), membrane (PrM and M) and envelope (E)-RSB- and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) in one open reading frame with subsequent cleavage [9].

The manuscript entitled «The oncogenic protein kinase MELK is essential for mitotic progression in basal - like breast cancer cells» begins with a functional overexpression screen utilizing a library of open reading frames encoding human kinases.

I enjoyed reading FRAMED this past week.

The genetically distinct RCD2 segregates in rough and smooth collies [6] and is caused by an insertion in RD3 that results in a stretch of altered amino acids and an extended reading frame [7].

Despite evidence for divergence at several loci, certain 1a characteristics were preserved including the length of the alternative reading frame / F protein (ARF / F) gene, and a subtype 1a - specific phosphorylation site in NS5A (S349).

Update: Perhaps understandably, CampaignGrid has declined to reply, but you can read their framing of the matter in their press release and the patent itself.

Update: Perhaps understandably, CampaignGrid has declined to reply, but you can read their framing of the matter in their press release and the patent...

The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide.

The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing

His miRNA switches consist of synthetic mRNA sequences that include a recognition sequence for miRNA and an open reading frame (ORF) that codes a desired gene, such as a regulatory protein that emits fluorescence or promotes cell death.

Patients with mutations in the chromosome 9 open reading frame 72 (C9ORF72) gene have all or some symptoms associated with both disorders.

These DPRs are translated by an unconventional non-ATG mediated form of translation from the hexanucleotide repeats in all three reading frames.

The deduced genomic structure of TMAdV was also similar to that of other mastadenoviruses and consists of 34 open reading frames (Fig. 2C).

Boxes above the central black line represent open reading frames (ORFs) that are encoded on the forward strand, while boxes underneath the black line represent reverse - strand encoded ORFs.

Although the region immediately around the CentO tracts for both centromeres 4 and 8 consists entirely of repetitive elements, the 750 kb CenH3 - binding domain of rice centromere 8 included 14 putative non-retroelement open reading frames (ORFs), including 4 that were shown to be expressed by reverse - transcriptase - coupled PCR [6].

The research also demonstrated how these non-random outcomes can be harnessed to produce a desired effect, such as a gene knockout or the reading frame restoration of a disease - causing allele.

Frequently insertions / deletions alter the open reading frame (ORF) of the target gene, disrupting the gene function downstream of the DSB.

An assay developed in our lab uses a reference protein that is translated from the same open - reading frame and separated from the protein of interest by a 2A self - cleaving peptide (Goedhart et al, 2010).

Additionally, P - eIF2α dependent translation of mRNAs regulated by upstream open reading frames (uORFs) contributes to the molecular signature of stemness.

A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7.

It is known that one of the pathways involved in cutaneous cancer is mediated through CDKN2A which is a gene associated with melanoma dysregulation through its pro-oncogenic products p16INK4a (Cyclin - Dependent Kinase Inhibitor P16) and p14ARF (P14 alternate open reading frame)[28].

developed in our lab uses a reference protein that is translated from the same open - reading frame and separated from the protein of interest by a

The sequence of this region is nearing completion by the BDGP and an attempt is being made to correlate open reading frames and transcription units with genetic loci (see Figure 4).

Open boxes indicate untranslated regions and colored boxes indicate open reading frames.

To test for Plasmodium falciparum DNA, PCR primers were designed that specifically amplify small subtelomeric variable open reading frame (STEVOR), apical membrane antigen 1 (AMA1), and merozoite surface protein 1 (MSP1) gene fragments with sizes of 100 to 250 base pairs (bp).