A large trial showing that men with newly diagnosed, advanced prostate cancer lived ten months longer, on average, when
they received docetaxel chemotherapy along with standard hormone therapy
Median overall survival of patients receiving nivolumab was 9.2 months, compared with six months for patients who
received docetaxel.
The men
receiving docetaxel had an average of 32.7 months before the cancer progressed by worsening scan results or symptoms, compared to 19.8 months for hormone therapy alone.
A total of 28.9 % of patients
receiving docetaxel had not progressed after 6 months, compared with 16.9 % of erlotinib patients.
Not exact matches
Researchers randomly selected 135 patients to
receive nivolumab, sold under the name Opdivo, and 137 others to
receive the chemotherapy drug
docetaxel.
Patients were randomised 1:1 to
receive therapy with ceritinib or chemotherapy (pemetrexed or
docetaxel).
It included 790 patients (median age of 63 years) who were enrolled and randomized from July 2006 to November 2012 to
receive either ADT plus
docetaxel every three weeks for six cycles or ADT alone.
In the ADT - plus -
docetaxel group, 45 patients whose disease progressed
received additional
docetaxel.
Patients
received 3 cycles of
docetaxel at either 80 mg / m2 or 100 mg / m2 and trastuzumab three times a week followed by 3 cycles of chemotherapy.
Disease - free survival was similar in the 9 - week and 12 - month arms among those patients who
received 100 mg / m2
docetaxel.
In contrast, among those who
received 80 mg / m2
docetaxel, 12 months of trastuzumab had superior disease - free survival.
The BMS trial, called Checkpoint - 017, randomized 272 patients to
receive either nivolumab intravenously every two weeks or the chemotherapy drug
docetaxel intravenously every three weeks.
The other group will
receive LY2181308 alongside
docetaxel.
Inclusion Criteria: • The participant may have no more than 2 prior lines of systemic therapies (neoadjuvant and adjuvant therapies will not be considered as a prior line of therapy) for advanced or metastatic disease and is suitable to
receive gemcitabine and
docetaxel therapy.
• The participant has
received prior treatment with gemcitabine or
docetaxel.