While trilaciclib has a huge potential market among cancer patients
receiving standard chemotherapies, investors want to keep their eyes on an ongoing trial evaluating a triple - combination of Roche's (NASDAQOTH: RHHBY) Tecentriq, chemotherapy, and G1's candidate.
In a study presented today at a meeting of women's cancer specialists, overall survival for women who
received standard chemotherapy treatment plus bevacizumab was a median five months longer than for women who received the standard chemotherapy treatment alone.
Those who
received standard chemotherapy plus Avastin, and then maintenance Avastin, for up to 10 months lived just over 14 months without their disease progressing compared with about 10 months for those receiving standard chemotherapy alone.
That means they have a high likelihood of disease recurrence and poor survival odds despite
receiving standard chemotherapy and optimum surgery.
Not exact matches
Now, patients with PD - L1 expression on at least half of their cancer cells can
receive pembrolizumab prior to
standard chemotherapy.
In a head - to - head clinical trial comparing
standard chemotherapy with the immunotherapy drug nivolumab, researchers found that people with squamous - non-small cell lung cancer who
received nivolumab lived, on average, 3.2 months longer than those
receiving chemotherapy.
Additionally, due to other medical issues or poor performance status (a measure that considers a patient's quality of life and ability to function during treatment), some stage III NSCLC patients are unable to
receive the
standard treatment of concurrent
chemotherapy and RT..
Patients were randomized to
receive either nivolumab or a single type of
standard chemotherapy until tumor progression was observed.
A third group of mice
received the
standard high dose of
chemotherapy at first, but once the animals» tumours started to shrink, the researchers dialled back the dose.
A large trial showing that men with newly diagnosed, advanced prostate cancer lived ten months longer, on average, when they
received docetaxel
chemotherapy along with
standard hormone therapy
One hundred and one patients with metastatic uveal melanoma at 15 centers in the United States and Canada were randomized to
receive either selumetinib or
standard chemotherapy.
Dr Fiona Blackhall, a senior lecturer in The University of Manchester's Institute of Cancer Sciences and a consultant based at The Christie NHS Foundation Trust — both part of the Manchester Cancer Research Centre — said: «In order to introduce precision medicine, where each cancer patient
receives treatment designed to target the genetic makeup of their individual cancer, we need to compare how effective the new targeted treatment is compared to
standard chemotherapy treatment.»
It showed that those patients who
received crizotinib did better with respect to improvement in symptoms and delay in growth of the cancer than those on
standard chemotherapy.
For a median (midpoint) PFS of 6.4 months in patients treated with
standard chemotherapy, the corresponding reduction of PFS in patient
receiving EGFR TKI would be 1.9 months.
Patients were randomized to
receive either immunotherapy or
standard - of - care
chemotherapy.
Two patients that had previously not responded to available
standard treatments, including surgery, external radiation, hormonal and
chemotherapy, have
received 225Actinium - PSMA - 617 as experimental therapy.
In phase 3 trials for adults with high - risk, secondary AML, there was a statistically significant improvement in overall survival compared to patients who
received a regimen using
chemotherapy drugs delivered in the
standard way.
The 11 evaluable patients enrolled in the brain cancer safety trial
received three infusions of vitamin C a week for 2 months followed by two infusions per week for 7 months while
receiving standard care radiation and
chemotherapy.
(In clinical trials, HER2 - positive patients
receiving Herceptin and
standard combination
chemotherapy had a 52 percent decrease in disease recurrence compared with patients treated with
chemotherapy alone.)
Standard chemotherapy is toxic to both cancer cells and normal cells, leading to symptoms like nausea, and limiting the dose a person can
receive.
Each patient will
receive gemcitabine and nab - paclitaxel, two
chemotherapy drugs that are
standard of care.
«In the study, investigators randomized 40 newly diagnose NSCLC patients to
receive either fish oil (EPA 2.2 g / day) or
standard care (no intervention; n = 24) while undergoing first - line
chemotherapy for 10 weeks.The investigator found that about 69 % of the patients who took fish oil gained or maintained muscle mass.
When results of treatment with
standard chemotherapy alone versus
chemotherapy plus Herceptin were compared, it was found that tumors shrank at least 50 percent in half the women getting
chemotherapy with Herceptin, compared with one - third of women
receiving chemotherapy alone.
Ten dogs with multicentric lymphoma will be recruited to
receive HBRT in conjunction with
standard chemotherapy.
Dogs with previously untreated, stage III to V, non-small cell lymphoma
receiving the
standard (16 - treatment) UW - Madison CHOP
chemotherapy protocol will qualify for treatment with radiation.
The case involved a 43 year old breast cancer patient who was
receiving chemotherapy at dose administered 80 % higher than the
standard.