Sentences with phrase «recent vaccine trials»

Indeed, recent vaccine trials have shown evidence of severe disease in some recipients who were previously exposed to virus.

Not exact matches

The recent phase 2 STEP trial of the HIV vaccine (V520) showed disappointing results, but another vaccine made by GeoVax will be moving into phase 2 clinical trials in the next few months based on promising phase 1 results.

An experimental vaccine to prevent the mosquito - borne viral illness chikungunya elicited neutralizing antibodies in all 25 adult volunteers who participated in a recent early - stage clinical trial conducted by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Collins, however, notes that Ebola vaccines had only been tested in macaques before they were used in human trials during the recent Ebola outbreak.

This clinical trial, which included 1,518 participants, was the basis for the recent approval from the Food and Drug Administration of a 2 - dose series of the 9 - valent HPV vaccine for adolescents,» writes Lauri E. Markowitz, M.D., of the U.S. Centers for Disease Control and Prevention, Atlanta, and colleagues in an accompanying editorial.

Vaccine efficacy was set at an average of 60 % (actual numbers depended on the different virus subtypes and on whether a person had been exposed due to a prior natural infection) based on recent phase III trial results for the Sanofi - Pasteur vaccine that had shown moderate effectiVaccine efficacy was set at an average of 60 % (actual numbers depended on the different virus subtypes and on whether a person had been exposed due to a prior natural infection) based on recent phase III trial results for the Sanofi - Pasteur vaccine that had shown moderate effectivaccine that had shown moderate effectiveness.

But more recent research among drug users with HIV in Bangkok has found that half of them carried subtype E, the other half B. Thus, say the trial's critics, Genentech's vaccine is inappropriate for at least half the people in the trial.

With enthusiasm for cancer immunotherapy mounting thanks to recent successes in the clinic with immune - based cancer treatments such as anti-CTLA-4 and anti-PD-1 antibodies, and the FDA approvals of sipuleucel - T prostate cancer vaccine and ipilimumab for the treatment of melanoma, and in light of the many promising immunotherapies now in clinical trials with potential for near - term FDA approval, the Cancer Research Institute launched the first annual Cancer Immunotherapy Awareness Month in June 2013 as a way to increase public awareness of the power of immunotherapy to revolutionize cancer treatment and of the need for continued public support for research to bring these treatments to more patients sooner.

High levels of inhibitory AMA1 antibodies were correlated with protection in a recent trial of AMA1 vaccines in Aotus monkeys [31], supporting the idea that AMA1 - C1 could have failed because it was insufficiently immunogenic.

In one eye - opening review of recent research, Charles Drake, M.D., Ph.D., of Johns Hopkins, who is also a member of CRI's clinical trials network, discussed several cancer vaccines that are making progress, including coxsackievirus A21, an oncolytic virus vaccine being studied in late stage melanoma, and NewLink's algenpantucel - L in pancreatic cancer (HyperAcute ® pancreas).

Recent clinical trials, such as the HVTN 505 study that was stopped because the vaccine was shown to be ineffective at preventing HIV, have generated new challenges to the field.

Recent attempts on extensive trials of cancer vaccines, using viral structures or substructures against several cancers such as cervices, prostate, lung, pancreatic and skin also failed to produce the overall protective clinical outcomes