(A) Eph receptor - ephrin binding at cell - cell contact sites results in the dimerization / clustering of Eph receptor - ephrin complexes, and initiation of canonical signals through
the receptor cytoplasmic domain.
Not exact matches
Cytoplasmic domains of members of the p24 family of putative cargo
receptors were shown to bind to coatomer, the coat protein of COPI - coated transport vesicles.
4 - 1BB (CD137) is a 30 kD type I glycoprotein and again a typical transmembrane
receptor in the TNFR superfamily, containing 4 full cysteine rich
domains, and a relatively short
cytoplasmic tail, and also signals as a trimer when bound to 4 - 1BBL, its known ligand in the TNF family.
Characterization of phosphorylation sites in the
cytoplasmic domain of the 300 kDa mannose -6-phosphate
receptor
Binding to the Eph
receptors can also cause the ephrins, which have a
cytoplasmic domain or a GPI - anchor, to transmit signals.