Sentences with phrase «receptor gene models»

We sequenced at sufficient depth to produce new, extended receptor gene models for 913 (73.1 %) OR and 246 (45.9 %) VR genes (the models and their sequences are provided in Datasets S4, S5, S6, S7).

Not exact matches

UT Southwestern biochemists studying mouse models found that the two proteins − steroid receptor coactivators 1 and 2 (SRC - 1 and SRC - 2)-- control genes for pulmonary surfactant components that promote the initiation of labor.

I work in hearing research, and I am now working on genes that are linked to blood (platelet) disorders as well as with mouse models expressing mutant steroid (androgen) receptor genes.

In 2005, Cagan's team created a general fly model of a human thyroid tumor caused by mutations in the Ret receptor tyrosine kinase gene, then screened a panel of drugs including a kinase inhibitor called vandetanib that suppressed the tumor (Cancer Res, 65:3538 - 41, 2005).

The role of αCaMKII autophosphorylation in the establishment of alcohol addiction Alanna Easton, King's College, UK Novel age - dependent learning deficits in a mouse model of Alzheimer's disease: implications for translational research Karienn Montgomery, University of Florida, USA Microsatellite regions upstream of the vole Avpr1a gene contribute to both individual and species differences in receptor expression Zoe Donaldson, Columbia University, USA Per Genes and Addiction Stephanie Perreau - Lenz, Central Institute of Mental Health, Germany

When we compare the complete gene models we have reconstructed with those currently annotated, both the amount of the receptor transcript sequence, and the proportion that is unique between receptors increases substantially.

Ad hoc perl scripts were used to further refine the gene models produced for VR and OR genes, deleting those predictions that fuse adjacent receptor genes or that are antisense to the annotated gene.

We similarly compared the 5 ′ ends in our reconstructed models to these data and found that a third of the receptor genes differ in less than 100 nucleotides and 80 % of the data is contained within a 1.5 kb window (Figure S8).

We next calculated the length for each receptor gene based on the existing Ensembl and our new reconstructed models.