Sentences with phrase «receptor genes study»

To determine which variant of the receptor genes study participants possess, DNA was collected via saliva samples for genetic analysis.

Not exact matches

One study, published in the 2008 September - October issue of the journal Child Development, suggests that some babies have a higher tendency to become agitated due to the formation of a certain receptor gene called dopamime.

UT Southwestern biochemists studying mouse models found that the two proteins − steroid receptor coactivators 1 and 2 (SRC - 1 and SRC - 2)-- control genes for pulmonary surfactant components that promote the initiation of labor.

Using blood samples, the study found that regulation of the oxytocin receptor gene OXTR was associated with development of the condition.

The authors note that DRD4 in particular, a dopamine receptor gene, has been extensively studied for its involvement in novelty - seeking behavior in primates, fish and birds.

Perhaps most significantly, in a study led by Frances Champagne — then a graduate student in Meaney's lab, now an associate professor with her own lab at Columbia University in New York — they found that inattentive mothering in rodents causes methylation of the genes for estrogen receptors in the brain.

DNA studies have zeroed in on various genes, including the glucocorticoid receptor gene, that dictate how intensely our brains and bodies react to stress.

The team also examined data from a prior genetic study of children with asthma and found that a variant of the dectin - 1 gene — which reduces production of the receptor — is strongly linked to increased asthma risk.

Only two women in the study had cancer - driving mutations — both in an estrogen receptor gene called ESR1 — in their recurrent tumors not seen in the original.

Juha Tapanainen of Oulu University Hospital in Oulu and colleagues at the University of Helsinki studied 15 brothers of infertile women who had mutations in the gene coding for the FSH receptor.

For this study, Dr. Lou and his colleagues focused on triple - negative breast cancer, which is difficult to treat, because it does not exhibit receptors for estrogen, progesterone or the HER - 2 / neu gene, which are targets for many current breast cancer treatments.

Among patients with advanced non-small cell lung cancer without a mutation of a certain gene (EGFR), conventional chemotherapy, compared with treatment using epidermal growth factor receptor tyrosine kinase inhibitors, was associated with improvement in survival without progression of the cancer, but not with overall survival, according to a study in the April 9 issue of JAMA.

A new study led by researchers at Boston Medical Center (BMC) indicates that variations in opioid receptor genes are associated with more severe neonatal abstinence syndrome (NAS) in newborn babies.

In the first study to show that the sensations from sampled alcohol vary as a function of genetics, researchers focused on three chemosensory genes — two bitter - taste receptor genes known as TAS2R13 and TAS2R38 and a burn receptor gene, TRPV1.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

Patients with metastatic colorectal cancer (mCRC) that are mutation - free in the KRAS, NRAS, BRAF and PIK3CA genes showed significant benefit from continuing anti-epidermal growth factor receptor (EGFR) therapy beyond progression following first - line chemotherapy and an anti-EGFR monoclonal antibody, according to study results (1) presented today at the ESMO 17th World Congress on Gastrointestinal Cancer in Barcelona, Spain.

After analyzing the genes of about a thousand bats, the researchers studied the exact composition of the MHC genes as well as the molecular structure of three families of olfactory receptor genes: TAAR2, TAAR3 and TAAR8.

A line of transgenic mice was studied that express the human LDL receptor gene in the liver under control of the transferrin promoter.

In the study, the researchers first examined DNA from domestic cats and identified 12 different genes for cat bitter receptors.

Christine Mißbach, first author of the study, analyzed the active genes in the insect antennae where the olfactory receptors are located and describes her discovery this way: «Astonishingly, the firebrat, which is more closely related to flying insects, employs several co-receptors, while the odorant receptors themselves are absent.»

Previous studies on natural resistance to malaria had implicated a section of human genome near to a cluster of receptor genes.

«Our ability to see this fundamental process in cancer formation was possible only because of access to revolutionary imaging technology,» said the study's senior author, Tom Misteli, Ph.D., Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, NCI.

«Natural resistance to malaria linked to variation in human red blood cell receptors: First study to identify protective effect of glycophorin gene rearrangements on malaria.»

In 2006, Penn researchers led by Kaplan and Eileen Shore, PhD, the Cali - Weldon Professor of FOP Research and a co-author on the current study, discovered how a mutation in the gene for a BMP receptor called Activin Receptor A type I (ACVR1) occurs in all individuals who have clasreceptor called Activin Receptor A type I (ACVR1) occurs in all individuals who have clasReceptor A type I (ACVR1) occurs in all individuals who have classic FOP.

Stroud was interested in studying epigenetic changes, or chemical modifications that turn genes on and off, in DNA for the glucocorticoid receptor gene that regulates passage of cortisol from mother to fetus.

While the gene encoding the Y6 receptor is altered in man, Professor Herzog believes it would be unwise to ignore it because the development of anti-obesity drugs relies heavily on mouse studies.

Previous studies have suggested, among other things, that differences in dogs» ability to communicate are associated with variations in the genetic material located close to the gene that codes for the oxytocin receptor.

A variant in the gene for this receptor previously had been linked to asthma in genetic studies, but the potential role of the receptor, called CDHR3, in asthma was unknown.

In the National Institutes of Health - funded study, researchers at Wake Forest Baptist identified and evaluated six rare gene variants within the beta2 - adrenergic receptor gene, the gene that may influence the response to beta agonist drugs.

More than 1,000 genes have estrogen receptor binding sites that control their expression, but less than one - tenth of those have been studied,» noted Jarjour, who is also an associate professor of immunology at Ohio State's College of Medicine.

Jarjour and his team studied a family of immune response genes called toll - like receptors (TLRs), which are responsible for sending out chemical «danger signals» when a bacteria or virus is detected.

This study further investigated the impact of nicotine use / smoking status and variation in the mu opioid receptor gene (OPRM1), specifically, an A118G single nucleotide polymorphism (SNP, or DNA sequence variation), on the effects of naltrexone on a range of drinking outcomes.

The study «A long - range cis - regulatory element for class I odorant receptor genes» published in Nature Communications was a collaborative effort between Tokyo Tech, the University of Tokyo, Nihon BioData Corporation and RIKEN Brain Science Institute.

As in earlier studies, the investigators, led by Ren Hen of Columbia University, first created a line of so - called knockout mice that lacked the gene encoding the receptor protein.

A new study links a deletion in a neurotransmitter receptor gene to a marked increase in an individual's ability to remember emotionally charged events.

Previous studies have shown a physiologic role for vitamin D in liver function, but «it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis,» says lead author Ning Ding, a research associate in the Gene Expression Laboratory.

This study was the first to consider whether variation in the burn receptor gene might influence alcohol sensations.

The study focused on a small subset of nuclear receptors, a large family of proteins that regulate gene expression in response to signals from various binding partners, including steroids and fats.

Covering the entire genome, the study discovered that a common variation in the melatonin receptor 1A (MTNR1A) gene is linked to the job - related exhaustion experienced by shift workers.

Of particular interest were the N - methyl - D - aspartate receptor (NMDAR) genes, which were further studied by qRT — PCR.

A new strategy for functional signaling studies of B ‐ cell lines by the CRISPR / Cas9 mediated deletion of BCR and B ‐ cell co ‐ receptor genes.

Insight into the novel role that NMDA receptors play in retinal responses to hypoxia may be derived from study of the coordinated expression patterns of genes that interact, either directly or indirectly, with the NMDA receptor; namely, the NMDA interactome.

Previous large - scale genetics studies have implicated 14 of the 110 genes as playing a role in breast cancer risk, such as the oestrogen receptor gene ESR1, showing that Capture Hi - C is an effective tool for picking up risk genes.

An Open Label, Phase II Study of Neratinib in Patients with Solid Tumors with Somatic Human Epidermal Growth Factor Receptor (EGFR, HER2, HER3) Mutations or EGFR Gene Amplification

Previous studies from many labs, including a group at Cambridge University, showed that when exposed to the primary female sex hormone, estradiol, the estrogen receptor activates genes that encourage tumor cells to grow and divide.

The genes examined in the current study, which code for the hormone urocortin 3 and its receptor, CRHR2, came from cattle.

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E... (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy.

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E

An Associate professor Phillip Morris, from Queensland University of Technology's Institute of Health and Biomedical Innovation was quoted as saying «The gene that we have been studying is a type of dopamine receptor gene.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.