Sentences with phrase «receptor knockout mice»

Zimmer et al. «Increased Mortality, Hypoactivity, and Hypoalgesia in Cannabinoid CB1 Receptor Knockout Mice», Proc.

For example, mice rendered vitamin D deficient exhibit enhanced cancer development and cancer growth (34), as do vitamin D receptor knockout mice (35).

Ledent et al. «Unresponsiveness to Cannabinoids and Reduced Addicitive Effects of Opiates in CB1 Receptor Knockout Mice», Science, 283 (5400): 401 - 404, 1999.

Western Diet — Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment — Prasant K — The American Journal of Pathology

Effects of muscarinic receptor antagonists on cocaine discrimination in wild - type mice and in muscarinic receptor M1, M2, and M4 receptor knockout mice Joseph L, Thomsen M. Behavioural Brain Research.

Walenbergh SMA, Houben T, Hendrikx T, Jeurissen MLJ, Gorp van PJ, Vaes N, Olde Damink SWM, Verheyen F, Koek GH, Lütjohann D, Grebe A, Latz E, Shiri - Sverdlov R. Weekly Treatment of 2 - Hydroxypropyl - β - cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice.

Glucagon receptor knockout mice are resistant to diet - induced obesity and streptozotocin - mediated beta cell loss and hyperglycaemia.

Cholesterol - induced hepatic inflammation does not underlie the predisposition to insulin resistance in dyslipidemic female LDL receptor knockout mice.

The insulin - receptor knockout mice developed cholesterol plaques that were more than twice the size of those found in the control animals.

Kidney - specific reconstitution of the A1 adenosine receptor in A1 adenosine receptor knockout mice reduces renal ischemia — reperfusion injury.

But the scientists found that the insulin - receptor knockout mice were on a fast track to atherosclerosis.

The endothelial cells in insulin - receptor knockout mice expressed more of the VCAM - 1 adhesion molecule that helps white blood cells grab onto the growing plaques, and blood vessels gathered four times as many white blood cells.

El - Khodor, B. F.; Dimmler, M. H.; Amara, D. A.; Hofer, M.; Hen, R.; Brunner, D. Juvenile 5HT (1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT (1A) receptor activation.

Mechanistically, CD8 + T cell depletion, IFN - γ neutralization, or implantation of tumors in IFN - γ receptor knockout mice abrogated the vessel perfusion enhancement and antitumor effects of ICB.

Oxytocin receptor in the Hypothalamus is Sufficient to Resue Normal Thermoregulation Function in Male Oxytocin Receptor Knockout Mice.

Not exact matches

As they studied brain activity in the knockout mice, the researchers also found prominent changes in a receptor in the brain known as mGluR5 and other proteins that support the function of neurons and synapses, said co-lead author Xiaoming Wang, M.D., Ph.D., senior research associate in Duke's department of pediatrics.

p11 knockout mice exhibit a depression - like phenotype and have reduced responsiveness to 5 - HT1B receptor agonists and reduced behavioral reactions to an antidepressant.

Knockout mice, which completely lacked the gene and so manufactured no mu opiate receptors, were all the more sensitive.

Although the Nppb - knockout mice lived a normal lifespan, when the researchers killed the receptor cells in the spinal cord, the mice died prematurely, suggesting that it could be dangerous to try humans, Hoon says.

As in earlier studies, the investigators, led by Ren Hen of Columbia University, first created a line of so - called knockout mice that lacked the gene encoding the receptor protein.

Ye, G - L.; Baker, K.B.; Mason, S.M.; Zhang, W.; Kirkpatrick, L.; Lanthorn, T.H.; Savelieva, K.V. GABAa receptor α1 subunit (Gabra1) knockout mice: review and new results.

In the study, «Multiple Risk Pathways for Schizophrenia Converge in Serine Racemase Knockout Mice, a Mouse Model of NMDA Receptor Hypofunction,» Dr. Coyle's group sought to determine whether this diverse pathology could be linked to NMDAR hypofunction, and thus used the SR - / - mouse mMouse Model of NMDA Receptor Hypofunction,» Dr. Coyle's group sought to determine whether this diverse pathology could be linked to NMDAR hypofunction, and thus used the SR - / - mouse mmouse model.

If the GH knockout Mice lived longer when being given exogenous GH would that be evidence of another, poorly understood receptor for GH?

With the help of conditional and function - selective knockout mice for the glucocorticoid receptor (GR) the lab identified critical cell types and novel mechanisms for anti-inflammatory activities of glucocorticoids in different inflammatory disease models.

Ye G.L, Baker K.B, Mason S.M, Zhang W, Kirkpatrick L, Lanthorn T.H, Savelieva K.V. GABAa receptor α1 subunit (Gabra1) knockout mice: review and new results.

TRPV1: Gene knockout of the pain receptor TRPV1 is one of a number of methods of slowing aging and extending life in mice that appears to work through altered insulin signaling.

Knockout of endothelin type B receptor signaling attenuates bleomycin - induced skin sclerosis in mice.

(17) Slow - aging growth hormone receptor knockout (GHRKO) mice are obese, but highly insulin sensitive: in such animals, surgical removal of visceral adipose tissue impairs insulin secretion and peripheral insulin action, in part by reducing adiponectin production.