These activities are independent of ephrin binding and / or kinase activity and their mechanism is not well understood but in some cases depends on Eph
receptor phosphorylation on serine / threonine residues (red circle).
The model was constructed to predict
the receptor phosphorylation levels in a cell under specific conditions for the immediate - to - short (minute - to - hours) response durations.
Not exact matches
«Rissman's prior work demonstrated that CRF and its
receptors are integrally involved in changes in another AD hallmark, tau
phosphorylation,» said William Mobley, MD, PhD, chair of the Department of Neurosciences and interim co-director of the Alzheimer's Disease Cooperative Study at UC San Diego.
The turkey erythrocyte model system was used earlier to show that a covalent modification of the
receptor (
phosphorylation) is associated with this process.
G protein — coupled
receptor (GPCR)-- dependent activation of protein kinase A (PKA) led to
phosphorylation of RCS at Ser55 and increased its binding to CaM.
In naïve cells,
receptor dimerization is effectively induced by all IFNs, leading to
phosphorylation of pre-associated STAT1 / STAT2 / IRF9 complexes, which subsequently form the transcription factor ISGF3.
After induction of interferon - stimulated genes (ISGs), the ubiquitin - specific protease USP18 docks to the
receptor complex via STAT2, thus interfering with
receptor dimerization and STAT
phosphorylation.
The authors discovered that FGF2 treatment forced a high percentage of astrocytic cell - cycle re-entry via FGF
receptor - induced
phosphorylation of ERK and mediated the generation of self - renewing Nestin - expressing NSCs.
γ - secretase and presenilin mediate cleavage and
phosphorylation of vascular endothelial growth factor
receptor - 1.
Role of initial protein
phosphorylation events and localized release - activated calcium influx in B cell antigen
receptor signaling.
Nucleotides and
phosphorylation bi-directionally modulate CaMKII binding to the NMDA -
receptor subunit GluN2B.
Samelson LE, Patel MD, Weissman AM, Harford JB, Klausner RD. Antigen activation of murine T cells induces tyrosine
phosphorylation of a polypeptide associated with the T cell antigen
receptor.
Zhang, Y. and Wolf - Yadlin, A. and Ross, P. L. and Pappin, D. J. and Rush, J. and Lauffenburger, D. A. and White, F. M. (2005) Time - resolved mass spectrometry of tyrosine
phosphorylation sites in the epidermal growth factor
receptor signaling network reveals dynamic modules.
Phosphorylation regulates removal of synaptic N - methyl - D - aspartate
receptors after withdrawal from chronic ethanol exposure.
Phosphorylation of tumor necrosis factor
receptor CD120a (p55) by p42 mapk / erk2 induces changes in its subcellular localization.
Nucleotides and
phosphorylation bi-directionally modulate Ca2 + / calmodulin - dependent protein kinase II (CaMKII) binding to the N - methyl - D - aspartate (NMDA)
receptor subunit GluN2B.
Phosphorylation of Src by phosphoinositide 3 - kinase regulates beta - adrenergic
receptor - mediated EGFR transactivation.
AP - 2 and epsin - 1 mediate protease - activated
receptor - 1 internalization via
phosphorylation - and ubiquitination - dependent sorting signals.
Phosphorylation of the tumor necrosis factor
receptor CD120a (p55) recruits Bcl - 2 and protects against apoptosis.
Importantly, stimulation of the crosslinking of CD4ζ chimeric
receptors led to tyrosine
phosphorylation as would be expected for a fully functional chimeric
receptor.
We showed that inactivation of the ABL kinases in breast cancer cells resulted in decreased expression of genes in the JAK / STAT and cytokine / cytokine
receptor pathway signatures, which may be due to decreased STAT5A mRNA expression and reduced STAT5
phosphorylation in ABL1 / ABL2 - depleted breast cancer cells.
That is high levels of PTP1B in the cell can lead to reduction in insulin
receptor activation or
phosphorylation; reduction in IRS - 1, IRS - 2
phosphorylation; reduction in activation of PI - 3 kinase.
By binding to the insulin
receptor, ILPs induce a
phosphorylation cascade that ultimately induces growth in the target tissues [1,5,7].
Characterization of
phosphorylation sites in the cytoplasmic domain of the 300 kDa mannose -6-phosphate
receptor
We have identified tyrosine and serine / threonine
phosphorylation sites of Eph
receptors and ephrins using mass spectrometry and investigated the signaling role of these
phosphorylation sites.
For example, our past work showed that two conserved tyrosine
phosphorylation sites in the juxtamembrane segment of the Eph
receptors not only mediate association with binding partners but also regulate
receptor kinase activity.
Gene ontology (GO) analysis of genes within 250 kb of a PORE sequence revealed enrichment in processes such as transcription regulator activity (p < 0.001), sex determination (p < 0.005), insulin
receptor signaling (p < 0.001), development (p < 0.0005), and protein
phosphorylation (p < 0.005).
Members of the vanilloid
receptor family (TRPV) are activated by a diverse range of stimuli, including heat, protons, lipids, phorbols,
phosphorylation, changes in extracellular osmolarity and / or pressure, and depletion of intracellular Ca2 + stores.
The balance between kinase and phosphatase activities determines the rate of
phosphorylation of the insulin
receptor kinase domain and several downstream targets including the phosphatidylinositol phosphates, the serine / threonine kinase Akt1 and the mTOR.
Activation of the insulin
receptor involves its autophosphorylation, which is followed by
phosphorylation of several target proteins in the signaling cascade.
Activation of the insulin
receptor leads to sequential activation of a number of protein and lipid kinases, including the serine / threonine kinases Akt1 and Akt2, which not only stimulate mTOR and thus downregulate autophagic protein catabolism (and thus cysteine supplies), but elicit
phosphorylation (inhibition) of FOXO1, a transcription factor that induces expression of proteins involved in both of the proteolysis recycling pathways: the autophagic / lysosomal pathway and the ubiquitin - proteasomal pathway.
Twelve - hour exposure of 3T3 - L1 adipocytes to H (2) O (2) or TNF - alpha resulted in the increase of c - Jun NH (2)- terminal kinase (JNK) activation and insulin
receptor substrate 1 (IRS1) serine 307
phosphorylation, concomitantly with the decrease in insulin - stimulated IRS1 tyrosine
phosphorylation and cellular glucose uptake.
Zinc is involved in insulin signaling by inhibiting the enzyme protein tyrosine phosphatase to increase
phosphorylation of the insulin
receptor.
METHODS: We treated 3T3 - L1 adipocytes with 2.5 mmol / l R (+) alpha - lipoic acid for 2 to 60 min, followed by assays of: 2 - deoxyglucose uptake; glucose transporter 1 and 4 (GLUT1 and GLUT4) subcellular localization; tyrosine
phosphorylation of the insulin
receptor or of the insulin
receptor substrate - 1 in cell lysates; association of phosphatidylinositol 3 - kinase activity with immunoprecipitates of proteins containing phosphotyrosine or of insulin
receptor substrate - 1 using a in vitro kinase assay; association of the p85 subunit of phosphatidylinositol 3 - kinase with phosphotyrosine proteins or with insulin
receptor substrate - 1; and in vitro activity of immunoprecipitated Akt1.
Seow K.M, Juan C.C, Hsu Y.P, Hwang J.L, Huang L.W, Ho L.T, Amelioration of insulin resistance in women with PCOS via reduced insulin
receptor substrate - 1 Ser312
phosphorylation following laparoscopic ovarian electrocautery, Human Reproduction 2007.
Extracts of cinnamon also activated insulin
receptor kinase and inhibited dephosphorylation of the insulin
receptor, leading to maximal
phosphorylation of the insulin
receptor (12).
In addition, altered enzymatic activities, such as an increased phosphatase activity and / or seryl
phosphorylation of the insulin
receptor substrate by glycogen synthase kinase - 3 (GSK - 3), have also been shown to be involved in some cases of type 2 diabetes (19,20).