Sentences with phrase «receptor signal transduction»

Involved in insulin receptor signal transduction, B - RAF, PDK1 programs etc..

My experience and training would be best suited to projects involving immunology and receptor signal transduction.

We discovered several Eph receptors and ephrins, and research in our laboratory is dedicated to the characterization of Eph receptor signal transduction mechanisms and biological functions using biochemical, mass spectrometry, molecular biology and cell biology approaches in conjunction with animal models.

Not exact matches

Bowen's lab studied several sigma receptor areas, including signal - transduction pathways, novel binding elements (both agonists and antagonists), and clinical applications.

Heterotrimeric guanine nucleotide — binding protein (G protein)-- coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane.

Epidermal growth factor receptor (EGFR) signal transduction plays a major role in growth, proliferation and differentiation of mammalian cells.

The isoforms beta ARK - 2 and beta - arrestin - 2 are highly enriched in and localized to the dendritic knobs and cilia of the olfactory receptor neurons where the initial events of olfactory signal transduction occur.

It is a rare autoimmune disease that results in the body producing antibodies against the NMDA receptor, a protein that plays an important role in signal transduction in the brain.

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

In 1995, I began graduate studies on signal transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 2000.

Signal transduction through the T - lymphocyte CD4 receptor involves the activation of the internal membrane tyrosine - protein kinase p56lck.

Intra - and intermolecular signal transduction mechanisms in membrane - embedded (photo --RRB- receptor / transducer complexes are studied using the photoreceptor / transducer complex NpSRII / NpHtrII, which is responsible for the photoactive behavior of the halophilic archaeon Natronomonas pharaonis.

His graduate and postdoctoral work led to seven first author papers in the Journal of Biological Chemistry, including four back - to - back papers on fundamental characterization of arachidonic acid pathways, and a Cell paper, which was the first to demonstrate cAMP - independent G protein participation in receptor - mediated signal transduction.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

«Cell surface receptors for signal transduction and ligand transport - a design principles study.»

Nuclear accumulation of the AT < sub > 1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation.

A simple but realistic mathematical model was created and then used to explore the design principles of signal transduction and transport receptors.

Figure 3A shows results of four control experiments, consisting of transgenic plants that lack one component of the complete signal transduction system (lack the receptor, lack the transmembrane HK, or lack the modified response regulator) or in which the critical phospho - accepting Asp53 residue was mutated.

One possibility is that previously - described receptor instability in vitro [5] precludes typical biochemical analysis, whereas in bacteria or plants, the receptor is continuously produced, and hence activates signal transduction.

While our analysis does not provide any details about how the computationally re-designed receptor binds the TNT ligand in planta, we consistently see reproducible signal transduction in our in vivo systems (bacterial and plant).

In addition, because we developed PhoB - VP64 for plants by activating endogenous HKs with exogenous cytokinins [12], it is likely that our synthetic signal transduction system (receptor → HK → PhoB: VP64 → signal receptive promoter) has false input or cross-talk from plant HK components.

We show that evolutionarily conserved histidine kinase signal transduction components [9], [10], [11] can be used to build a synthetic signal transduction system, and we then use this system to link input from computationally re-designed receptors to a plant response.

To determine if input from the PBP receptor could transcriptionally activate our synthetic signal transduction system, we produced plants containing: ssTNT.R3 → Fls - Trg - PhoR → PhoB - VP64 → PlantPho promoter:: GUS (Figure 1), hereafter called the complete signal transduction system.

Our synthetic signal transduction pathway is able to functionally link input from the computationally re-designed receptors to a plant response system, producing a prototype detector plant.

Homer 1, an actin binding protein that is induced by BDNF [72], belongs to a family of scaffolding proteins that localize at the postsynaptic density (PSD)[73, 74] and is believed to play a critical role in signal transduction, synaptogenesis and receptor trafficking at synapses [75].

We describe the production of transgenic plants using input from computationally re-designed receptors that signals through a synthetic signal transduction system.

Vorinostat interferes with the signaling transduction pathway of T - cell receptor and synergizes with phosphoinositide - 3 kinase inhibitors in cutaneous T - cell lymphoma

The signal transduction mechanisms of Eph receptors are intriguing, and complex, because these receptors engage in multiple modes of signaling.

We've been particularly involved in understanding the effects of ethanol on hormone and cytokine receptor - dependent signal transduction.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

This work revealed new roles for XBP - 1 in regulating signal transduction through the B cell receptor; in regulating the expression of important transcription factors in B cells; in maintaining proper lipid synthesis and protein glycosylation in B cells; and in colonization of stimulated B cells into the bone marrow for sustention of antibody production.

Significance of the carbohydrate moiety of the rat ovarian luteinizing - hormone / chorionic - gonadotropin receptor for ligand - binding specificity and signal transduction

Felder et al. «Anandamide, An Endogenous Cannabimimetic Eicosanoid, Binds to the Cloned Human Cannabinoid Receptor and Stimulates Receptor - Mediated Signal Transduction», Proc.

It remains to be elucidated whether differences in translation and / or protein modification of receptors or signal transduction machinery underlie sexually dimorphic detection of pheromones.

Additionally, most of the cancer cell lines expressing olfactory receptors express the effectors necessary for OR - mediated signal transduction.

Sethna F, Zhang M, Kaphzan H, Klann E, Autio D, Cox CL, Wang H. (2016) Calmodulin activity regulates group I metabotropic glutamate receptor - mediated signal transduction and synaptic depression.

BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

Background: Olfactory receptors (ORs) recognize odorant molecules and activate a signal transduction pathway that ultimately leads to the perception of smell.

The gene expression viewer has proven to be an ideal tool for comparing gene family members, genes whose products participate in ligand — receptor interactions, and genes involved in signal transduction pathways.