Sentences with phrase «receptor subunit»
A receptor subunit refers to a part of a receptor molecule that helps in receiving and transmitting signals within the body. It works like a puzzle piece that fits specific signals, allowing information to be processed and sent to different parts of the body. Full definition
Berg LK, Larsson M, Morland C, Gundersen V (2013) Pre - and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses Neuroscience, 230, 139 - 50 PubMed 23159309
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Maintenance of enriched environment - induced changes of auditory spatial sensitivity and expression of GABAA, NMDA, and AMPA receptor subunits in rat auditory cortex.
mRNAs and protein expression for HIF - 1α, VEGF, nitric oxide synthase, and glutamate receptor subunits NMDAR1, GluR2, GluR3 were each found to be upregulated at 3 h and 24 h, but all returned to control levels by 14 days.
His research accomplishments include the discovery that glycine is a coagonist of NMDA receptors (Science 241, 835; 1988) and characterization of the topology of a glutamate receptor subunit (Neuron, 14, 373; 1995).
Electron micrograph showing NMDA receptor subunits NR2B (immunogold particles) at the synapse as well as in extrasynaptic membranes (arrows) of nerve terminals (ter) making asymmetric synapses with dendritic spines (sp) in the dentate molecular layer.
The lab has generated «floxed» alleles of GABAA receptor subunit genes that allow us to ablate the respective subunit in a subregion specific manner — e.g., in hippocampal subregions or the amygdala — either via a cross with cre - transgenic mice or via stereotaxic injection of cre - expressing viruses into defined brain regions.
In addition to clustering AMPA receptors, via a dimerisation domain, PICK1 has been shown to have multiple effects in neurons including roles in the insertion of AMPA receptors (Daw et al 2000), the internalisation of kainate receptors (Hirbec et al 2003) and the regulation of AMPA receptor subunit composition (Terashima et al 2004).
The CHRNA5 - CHRNA3 - CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African — Americans and in European — Americans
Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70 % ientical in sequence.
He examined the mice's brains and found that the cells had lower levels of delta GABA, a key receptor subunit that stops nerves from firing too often and has been linked to epileptic seizures.
X-ray crystal structure of the NMDA receptor showing its mushroom - like shape, with receptor subunits in different colors.
This block is caused by mutations of the gene encoding the γc cytokine receptor subunit of interleukin - 2, -4, -7, -9, and -15 receptors, which participates in the delivery of growth, survival, and differentiation signals to early lymphoid progenitors.
To narrow down the list, a team of researchers led by Henry Lester, a neuroscientist at the California Institute of Technology in Pasadena, designed a mouse with a mutant version of the a4 * acetylcholine receptor subunit.
HIPK2 - Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death
Jensen V, Rinholm JE, Johansen TJ, Medin T, Storm - Mathisen J, Sagvolden T, Hvalby O, Bergersen LH (2009) N - methyl - D - aspartate receptor subunit dysfunction at hippocampal glutamatergic synapses in an animal model of attention - deficit / hyperactivity disorder Neuroscience, 158 (1), 353 - 64 PubMed 18571865
In her thesis, Megan explored the effect of the neurotrophic secreted amyloid precursor protein alpha on protein synthesis, specifically examining changes in the production and expression of the AMPA receptor subunit GluA1.
Setdb1 histone methyltransferase regulates mood - related behaviors and expression of the NMDA receptor subunit NR2B.
Hui - Chen Lu, Ernesto Gonazlez, and Michael C. Crair (2001) «Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition», Neuron, 32: 619 - 634.
It has been shown to interact with a number of glutamate receptors - GluA2 and GluA3 AMPA receptor subunits (Dev et al 1999, Xia et al 1999), the GluK1 and GluK2 subuits of the kainate receptor (Hirbec et al 2003) and the mGlu7 receptor (Dev et al 2000) via their extreme C - terminal PDZ binding motifs.
At Emory, the labs of Stephen Traynelis and Hongjie Yuan have published an analysis of ExAC data, focusing on the genes encoding two NMDA receptor subunits, GRIN2A and GRIN2B.
These are structurally related, with less than 20 % sequence identity, to other excitatory amino acid receptor subunits, including the NMDA receptor subunit NMDAR1 (NR1).
The resulting 3 - D model of the receptor, which looks something like a bouquet of flowers, shows where the receptor subunits are located, and gives unprecedented insight into their actions.
However, because the a4 * receptor subunit is important for learning, memory, appetite, and biological clock timing, treatments that narrowly target a4 * receptors could cause significant side effects, says Daniel McGehee, a neurobiologist at the University of Chicago.
However, IL - 15Rα is not merely an IL - 15 receptor subunit, as mice lacking either IL - 15 or IL - 15Rα have unique phenotypes.
We could unambigously demonstrate that dimerization of the receptor subunits is induced by ligand binding.
Thus stargazin is critical in the trafficking of AMPA receptor subunits to the synapse, via an interaction with SAP97, and is then also critical in determining the level of surface expressed receptor within the synapse via an interaction with PSD95.
The interaction occurs principally in the biosynthetic and secretory pathways (Sans et al 2001) and SAP97 provides a linkage between the AMPA receptor subunit and the microtubule - based transport mechanisms, via an interaction with the motor protein myosin VI (Wu et al 2002).
Detailed studies of IFN recognition by its receptor subunits IFNAR1 and IFNAR2 revealed that binding affinity rather than structural differences are responsible for differential IFN activities, suggesting regulation at the level of receptor assembly (1 - 5).
The new study found that prebiotic treatment alters the levels of brain - derived neurotrophic factor (BDNF), which is important for neuronal growth and survival; N - methyl - D - aspartate (NMDA) receptor subunits; and amino acids associated with signaling by the neurotransmitter glutamate, an excitatory neurotransmitter4, 12,13.