Specifically, when capsaicin frequently binds to
receptors within the human central nervous
system's TRPV1 channel (the sensory
receptor system for pain and heat detection), these
receptors deplete and this depletion results in a whole host of benefits for the central nervous
system at large, including terminating cancer cells, increasing the metabolic rate and digestive
efficiency, increasing circulatory blood flow, and combatting inflammation, and making you feel better about the world.
By examining a number of
receptor systems (see figure), the researchers demonstrated that
receptor system response can be characterized as being either avidity - controlled, which depends primarily on ligand capture
efficiency; consumption - controlled, where the ability to internalize surface - bound ligand is the primary control parameter; and dual - sensitive, in which both the avidity and consumption parameters are important.