Sentences with phrase «receptor system response»

By examining a number of receptor systems (see figure), the researchers demonstrated that receptor system response can be characterized as being either avidity - controlled, which depends primarily on ligand capture efficiency; consumption - controlled, where the ability to internalize surface - bound ligand is the primary control parameter; and dual - sensitive, in which both the avidity and consumption parameters are important.

Not exact matches

OCA is the first in a new class of drugs, farnesoid X receptor (FXR) agonists, and the response of the patients to OCA shows that abnormalities in the system it targets may be critical for this condition.

Activation of these receptors led to a «massive mobilisation» of myeloid - derived suppressor cells (MDSCs), which play a crucial role in lowering the immune system response back down to normal levels (European Journal of Immunology, DOI: 10.1002 / eji.201040667).

When the receptors detect the presence of invading bacteria, they send signals to the body's immune response system.

Cincinnati Cancer Center (CCC) and UC Cancer Institute researchers have found that a vaccine, targeting tumors that produce a certain protein and receptor responsible for communication between cells and the body's immune system, could initiate the immune response to fight cancer.

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT).

Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.

New findings published in the journal Nature Chemical Biology by UNC School of Medicine scientists show that MRGRPX2, a receptor protein on the surface of mast cells, can trigger the immune system response that leads to itching associated with some opioids.

The rationale for using CT - 011, an immunotherapy antibody that blocks the programmed death (PD)-1 receptor, is to boost the function of the immune system by inhibiting PD - 1 whose function, in part, is to inhibit T - cell response.

The women's immune systems — in mounting a response against the synaptic receptors present in the ovarian growths — inadvertently attacked a receptor in the brain called N - methyl - D - aspartate receptor, or NMDAR.

Figure 3A shows results of four control experiments, consisting of transgenic plants that lack one component of the complete signal transduction system (lack the receptor, lack the transmembrane HK, or lack the modified response regulator) or in which the critical phospho - accepting Asp53 residue was mutated.

We show that evolutionarily conserved histidine kinase signal transduction components [9], [10], [11] can be used to build a synthetic signal transduction system, and we then use this system to link input from computationally re-designed receptors to a plant response.

Our synthetic signal transduction pathway is able to functionally link input from the computationally re-designed receptors to a plant response system, producing a prototype detector plant.

Current studies focus mainly on two receptor systems - the mast cell surface receptor, FcεRI, and the receptor for epidermal growth factor that operate in immunological and cell proliferation responses.

I am currently working with Zika virus and how it affects the T cell response and T cell signaling through tumor necrosis receptor (TNFR) signaling components OX40, 4 - 1BB, and CD27 in specific mouse model systems.

LA JOLLA — When a receptor on the surface of a T cell — a sentry of the human immune system — senses a single particle from a harmful intruder, it immediately kicks the cell into action, launching a larger immune response.

The antibody produced by the immune system in response to Graves» disease is called TRAb or thyrotropin receptor antibody.

Inflammation leads to disturbed gut flora (or maybe it's the other way around — the classic chicken and the egg dilemma), SIBO, malfunctioning toll - like receptors, and leaky gut, allowing proteins to enter the body and provoke an inflammatory response by the immune system.

The T2R defense system continues in our respiratory system, where taste receptor cells have been shown to monitor the bacteria in our tissues and initiate an innate immune response if pathogenic species are detected.