Sentences with phrase «receptors of the central nervous system»

Not exact matches

In other words, it looks like there's something in the human central nervous system that an educated chili head might call an Endo - Capsaicin Receptor system (a system designed to sense and process capsaicin that, when activated, can have significant effects on the central nervous system at large) and that when this system is frequently activated by the digestion of capsaicin, we see all kinds of health benefits.

Specifically, when capsaicin frequently binds to receptors within the human central nervous system's TRPV1 channel (the sensory receptor system for pain and heat detection), these receptors deplete and this depletion results in a whole host of benefits for the central nervous system at large, including terminating cancer cells, increasing the metabolic rate and digestive efficiency, increasing circulatory blood flow, and combatting inflammation, and making you feel better about the world.

«Opioids have both analgesic and rewarding effects and they have these effects through mu opioid receptors and these receptors are expressed in pain terminals in the spinal cord and in areas of the brain that regulate pain but are also expressed in areas that regulate reward and a sense of pleasure,» Boyle said, referring to cells found in a person's central nervous system that bind to naturally occurring opioid compounds and reduce pain and make people feel much better.

Moreover, in situ hybridization and RNA blot analysis indicate that the 5HTlc receptor is expressed in neurons in many regions of the central nervous system and suggest that this subclass of receptor may mediate many of the central actions of serotonin.

Prior to Gouaux's study, scientists had only a limited view of how those subtypes were arranged in the NMDA receptor complex and how they interacted to carry out specific functions within the brain and central nervous system.

Stimulation of α2b receptors in vascular smooth muscle produced hypertension and counteracted the clinically beneficial hypotensive effect of stimulating α2a receptors in the central nervous system.

The sensation of touch starts in the peripheral nervous system — in receptors at the surface of the skin — and travels along nerves that connect into the central nervous system.

«We know there are receptors for vitamin D throughout the central nervous system and in the hippocampus,» said Robert J. Przybelski, a doctor and research scientist at the University of Wisconsin School of Medicine and Public Health.

«These studies will provide new information on GABA signaling and the interactions among its receptor subtypes that may be relevant to the action of GABA throughout the central nervous system,» Walton said.

The identification of functions of individual GABAA receptor subtypes is likely to enhance the understanding of fine - tuning of processes underlying central nervous system function.

Tsou et al. «Immunohistochemical Distribution of Cannabinoid CB1 Receptors in the Rat Central Nervous System», Neuroscience, 83 (2): 393 - 411, 1998.

Abbreviations: ACVR2A, activin A receptor type IIA; BMP, bone morphogenetic protein; BMPR, BMP receptor, type II; CNS, Central nervous system; DA, dopaminergic; DMEM / F12, Dulbecco's modified Eagle's medium nutrient mixture F - 12; E, embryonic day; GDF, growth differentiation factor; GO, gene ontology; KEGG, Kyoto encylopedia of genes and genomes; MAPK, Mitogen - activated protein kinase; mDA, midbrain dopaminergic; PD, Parkinson's disease; RIPA, radioimmunoprecipitation assay; SN, Substantia nigra; TGF - β, transforming growth factor - β; TH, tyrosine hydroxylase; VM, ventral midbrain / mesencephalon; Zeb2, Zinc finger E-box-binding homoeobox 2

The endocannabinoid system regulates energy homeostasis through G protein — coupled cannabinoid - 1 receptors5, 6 located in the central nervous system and in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorders.

The scientists behind Rozerem's development explain that by targeting melatonin receptors — which are responsible for the brain's sleep - wake cycle — it may avoid the groggy side effects of sedative drugs, which work by slowing down the central nervous system.

Experts at the University of Pennsylvania eventually identified the mysterious antibody as a type that targets receptors in the central nervous system that are involved in memory and neuron function.

These receptors tell the central nervous system, (CNS) the amount of tension (length) inside a muscle / tendon group.

Valerenic acid is thought to interact directly with receptors in the central nervous system (CNS) that handle the production of γ - aminobutyric acid (GABA), a neurotransmitter that promotes relaxation and the onset of deep sleep.

These receptors are found throughout the central nervous systems of humans and non-human animals, and play an important role in pain pathways.

Research investigating the functional role of the A-1 allele has found that carriers of this allele, in contrast to carriers of the A-2 allele, have fewer brain D2 dopamine receptors [23, 24], have diminished glucose metabolism in the brain [25], are more attuned and responsive to stress [26], and exhibit reduced dopaminergic activity in the central nervous system [23].

Saliva collection was chosen because it is the most frequently used procedure in studies in young children.11, 13,14,17,25 This convention has emerged because of the ease of collection for assessments at multiple time points, the stress - free nature of the procedures, and the observation that salivary cortisol levels reflect levels of the biologically active hormone available to central nervous system receptors.39