Sentences with phrase «recessive allele in»

The most - recessive allele in this series is e, restricting (refusing) any expression of black.

The relatively high estimates of the frequencies of the unfavourable recessive alleles in each breed, especially for hip dysplasia, suggest that it would be possible to gain considerable genetic progress by selection against a major gene.

Not exact matches

Further analysis revealed that a single - letter change in the gene accounted for 46 per cent of the population's hair colour variation, with the blonde allele being recessive to the dark hair allele.

We report a variety of biallelic effects on organismal phenotype attributable to combinations of recessive Xpd alleles, including the following: (i) the ability of homozygous lethal Xpd alleles to ameliorate a variety of disease symptoms when their essential basal transcription function is supplied by a different disease - causing allele, (ii) differential developmental and tissue - specific functions of distinct Xpd allele products, and (iii) interallelic complementation, a phenomenon rarely reported at clinically relevant loci in mammals.

We addressed the potential of different recessive alleles to contribute to the enigmatic pleiotropy associated with XPD recessive disorders in compound heterozygous mouse models.

Our data suggest a re-evaluation of the contribution of «null» alleles to XPD disorders and highlight the potential of combinations of recessive alleles to affect both normal and pathological phenotypic plasticity in mammals.

Extension of the above concept implies that recessive mutations can enter evolutionary selection in F1 provided that the second allele carries a different recessive alteration.

The recessive s (susceptible) allele is found in AKR / J, C57BL / 6, BALB / c, CBA / J, NFS, NZB and 129 / J.

F1 hybrid progeny from matings with the good - hearing strain CAST / Ei exhibited good hearing even at advanced ages, indicating that the allele (s) responsible for hearing loss in C57BR / cdJ are recessive.

We imputed these variants into 104,220 individuals down to a minor allele frequency of 0.1 % and found a recessive frameshift mutation in MYL4 that causes early - onset atrial fibrillation, several mutations in ABCB4 that increase risk of liver diseases and an intronic variant in GNAS associating with increased thyroid - stimulating hormone levels when maternally inherited.

As part of their study of genetics, students in Shannon Dziwanowskis seventh - grade science class at Csar Chvez Academy Middle School in Detroit, Michigan, spend the first minutes of class reviewing a worksheet on dominant and recessive alleles, which are alternative forms of genes.

«E», normal extension of black, allows the A-series alleles to show through, and «e», recessive red / yellow, overrides whatever gene is present at the A locus to produce a dog which shows only phaeomelanin pigment in the coat.

That would mean that both the Sire and the Dam would have to contribute a recessive b allele on to the puppy in order for it to be a Chocolate Labrador.

The traditional color, produced when one or both genes have the dominant allele, is commonly referred to as black or black and rust (also called black and tan), while the most common variation, due to both genes having the recessive allele, produces what is called a red or red and rust Doberman in America and a «brown» Doberman in the rest of the world, which is primarily deep reddish - brown with rust markings.

Recessive traits must have homozygous alleles in order to be expressed.

Many of endearing unique traits in dog breeds today are the result of homozygous recessive alleles being forever paired together in the future generations.

NCL is an autosomal recessive inherited disease i.e. the disease develops in dogs, who inherit the mutated allele from both parents.

For a lab to have the silver color that has become so popular over the last several years, this D pair must have two recessive alleles (dd) and results in a dilute color of the solid color.

Moreover, overrepresentation of a popular sire's genome risks the widespread dissemination of monogenetic inherited disorders by inflating the allele frequency of recessive deleterious variants carried by the sire and increasing the probability of identity by descent of undesirable alleles in his descendants [18,20,21].

The test Vetgen offers detects the presence or absence of the recessive allele that results in long coats when present in two copies, and as such allows dogs with short coats that carry a hidden «long coat» allele to be detected.

Testing for this mutation along with Ay and recessive black (a) also allows for the identification of aw alleles in those breeds where it is present.In breeds where only the Ay and at alleles are present, the Ay test can be used to see if the fawn / sable dog is Ay / Ay (homozygous) or only has one Ay (heterozygous).

Genetic transmission of deafness in dogs with the recessive alleles of this pigment gene, such as the Dalmatian (which is homozygous for sw), is less clear.

The Hairless allele (the wild type) is a dominant (and homozygous prenatal lethal) trait, while the Powderpuff allele acts as a simple recessive trait in its presence.

If a dominant and recessive allele are paired, the dominant trait can override the recessive trait or result in a «mixed» trait that becomes its own phenotype, such as the chocolate Labrador Retriever.

Allelic effects at the major gene locus showed nearly to complete dominance, with a recessive, unfavourable allele in both traits.

Over the last few decades, inbreeding and loss of genetic diversity have resulted in an increase in the expression of recessive alleles as well as inbreeding depression, which affects things like fertility, puppy mortality, and lifespan.

Although the visual effect can be the same, it is easy to confuse this with the subtle hint of bronze (liver) that shows through in coats of some black dogs that carry an incompletely - masked recessive allele (one of the gene pair) for «a dilute» such as liver - chocolate.

Through the examination of SNP allele frequencies in the Labrador Retriever family, we identified 2 chromosomes harboring CMS candidate genes that showed an inheritance pattern consistent with autosomal recessive transmission.

In any case, brindle is recessive to black self - color and to saddle patterns (as in GSD, Airedale, Rottweiler), and possibly to the yellow e - allele dog as welIn any case, brindle is recessive to black self - color and to saddle patterns (as in GSD, Airedale, Rottweiler), and possibly to the yellow e - allele dog as welin GSD, Airedale, Rottweiler), and possibly to the yellow e - allele dog as well.

It seems that, as in other breeds, the br allele lies in between those other two alleles in terms of dominant / recessive «power.»

Allele frequencies in regions on the 13 chromosomes harboring candidate genes were evaluated for a pattern consistent with a recessive trait (Table S2).

For SNPs for which the expected distribution of genotypes violated the assumptions of Chi - square, genotypes were combined in accordance with knowledge regarding dominant / recessive alleles inferred from the existing literature (see table 1).