Neutralization could be measured in cell culture with real virus or
a recombinant vaccine virus expressing the Ebola virus surface protein, Günther says.
Not exact matches
One of the
vaccines, which is based on a
recombinant vesicular stomatitis
virus expressing the glycoprotein of the Zaire strain of the Ebola
virus (VSV - ZEBOV), was recently shown to be extremely effective with 100 per cent efficacy against the lethal Ebola
virus disease in WHO - funded studies carried out in Guinea and Sierra Leone.
Researchers developed the NDV - H5Nx
vaccine with a
recombinant virus technique similar to the one used to make NDV - H5N1 and NDV - H7N9
vaccines in 2015.
When the researchers exposed chickens to lethal doses of the avian influenza
virus and the Newcastle
virus, birds inoculated with the
recombinant vaccine produced antibodies against both
viruses, offering protection against both diseases.
The Viral Vector Core Facility produces
recombinant virus - vectored
vaccines for pre-clinical validation experiments and GMP starting material.
At the heart of this endeavor is a strategic focus on
recombinant protein
vaccines, which rely on purified elements of a bacteria or
virus to elicit immunologic protection.
Lack of preexisting
virus - neutralizing antibodies in the human population suggests that these novel adenoviral
recombinants may provide improved
vaccine carriers for use in humans.
Through development of
recombinant viral
vaccines, developers can reduce risks associated with the presence of live and inactivated
viruses.
While the USDA recognizes four categories of
recombinant vaccines, only the «Vectored
Virus» Category is commercially available.
Recombinant:
Vaccine manufactured through gene cloning (plasmid expressed) or by recombining selected DNA from a pathogenic organism with DNA from another
virus (viral vectored), leading to the expression, following inoculation, of only essential antigens required to immunize.
For cats, CSU recommends only the Purevax rabies
vaccine by Merial, a
recombinant virus in a canarypox carrier.
Vaccine is also available in the
recombinant format w here a live harmless
virus (not the distemper
virus at all modified or otherwise) is used to carry the portion of the distemper
virus which generates the immune - response.
While the USDA recognizes four categories of
recombinant vaccines, only the vectored
virus category is commercially available.
The newest generation of
vaccines includes
recombinant vaccines that use only small fragments of the disease agent, which are inserted into a harmless carrier
virus.
Since the
virus used in
recombinant vaccines is alive, there is no potentially harmful adjuvant included in the product (see below).