TRINOVA - 1 was a randomized prospective phase III clinical trial that added trebananib or placebo to standard chemotherapy (weekly paclitaxel) among 919 women with
recurrent ovarian cancer patient from 179 sites in 32 countries.
Not exact matches
Based on results of the current study described in a report online June 18 in the journal
Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced ovarian c
Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in
patients with
recurrent advanced
ovarian cancercancer.
The ENGOT - OV16 / NOVA trial evaluated the efficacy and safety of the PARP inhibitor niraparib as maintenance therapy in
patients with
recurrent ovarian cancer who respond to platinum - based chemotherapy.
He concluded: «Once it is approved by the regulatory authorities, I'll consider niraparib for all my
patients with
recurrent ovarian cancer who respond to platinum regardless of BRCA status.»
In that randomized, double - blind, placebo - controlled, phase III trial, 561
patients with
recurrent epithelial
ovarian, fallopian tube, or primary peritoneal
cancer who were in complete or partial response to platinum - based chemotherapy were treated with either rucaparib 600 mg orally twice daily (372
patients) or to placebo (189
patients).
«Both the efficacy and safety results from the ARIEL3 study reinforce the important role of Rubraca in the treatment of
recurrent ovarian cancer and expands the treatment options for
patients and physicians battling this disease,» he said.
ZEJULA is the first and only once - daily PARP inhibitor for the maintenance treatment of adult
patients with
recurrent epithelial
ovarian, fallopian tube, or primary peritoneal
cancer who are in a complete or partial response to platinum - based chemotherapy.1 - 3
ZEJULA is indicated for the maintenance treatment of adult
patients with
recurrent epithelial
ovarian, fallopian tube, or primary peritoneal
cancer who are in a complete or partial response to platinum - based chemotherapy.
A phase II study of allogeneic natural killer cell therapy to treat
patients with
recurrent ovarian and breast
cancer.
The FDA has granted approval of rucaparib for maintenance therapy in
patients with
recurrent epithelial
ovarian, fallopian tube, or primary peritoneal
cancer.