This year's Nobel Prize in Physiology or Medicine has been awarded to Yoshinori Ohsumi, a cell biologist at the Tokyo Institute of Technology's Frontier Research Center, for his work on autophagy, the process in which cells degrade and
recycle cellular components.
After more than six years of research, the research team led by María Soengas, head of CNIO's Melanoma Group, showed that RAB7 acts as an orchestra director, determining the fate of melanoma cells: at high concentrations of RAB7,
cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation of toxic
components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to
recycle metastatic proteins, favouring their dispersal throughout the body.