Consumption of nopal cactus fruit positively affects the body's
redox balance, decreases oxidative damage to lipids, and improves antioxidant status in healthy humans
The cellular
redox balance must be tightly regulated by several (enzymatic) antioxidants and dietary antioxidants; however, in case of chronic inflammation, the antioxidant system may be depleted and prolonged oxidative stress occurs.
4 - The Redox is at the heart of it all, as lipid peroxidation load drops
redox balance is greatly affected, meaning a cell redox state of little oxidative stress and inflammatory gene activation (by absence of lipid peroxidation after lipid remodeling).
Conversely, antioxidant treatment in healthy conditions where the offspring vascular physiology is already replenished with an appropriate
redox balance may, in fact, lead to excess NO bioavailability, tipping the balance in the opposite direction.
The regulatory system to control
redox balance involves sugar - dependent gene regulation and protein phosphorylation.
Without dynamic control of
redox balance animals lose their ability to survive on sugar - rich food.
Teesalu et al., Salt - Inducible Kinase 3 Provides Sugar Tolerance by Regulating NADPH / NADP +
Redox Balance, Current Biology (2016), http://dx.doi.org/10.1016/j.cub.2016.12.032
With this in vivo model, the research team uncovered evidence of distinct organellar perturbations in
redox balance following inhibition of GSH synthesis with buthionine sulfoximine, demonstrating increased mitochondrial oxidation in response to GSH depletion compared to the cytosol.
They add, that «by identifying and characterizing LMIT1 as a mitochondrial iron importer, we established a direct connection between iron uptake, mitochondrial
redox balance and the development of virulence in Leishmania, significantly expanding future options for controlling these serious human infections.»
«Safe utilization of dietary sugars requires dynamic control of
redox balance.»
The system how
the redox balance is controlled in response to changes of sugar feeding has so far been insufficiently understood.
SIK3 phosphorylates and activates a key enzyme of glucose metabolism called Glucose -6-phosphate dehydrogenase G6PD, which is an important regulator of cellular
redox balance.
Not exact matches
It is interesting that the
balance of
redox modulation of vascular tone, imposed by the O2 • −: NO ratio, may be tipped in either direction to promote disequilibrium, as maternal treatment with vitamin C in normoxic pregnancy also promoted endothelial dysfunction.
Getting our
redox system back into
balance and protecting our mitochondria is the key to optimal health and a vital, energetic old age.