Sentences with phrase «reduce circulating concentrations»

TCD - associated cognitive performance has been extensively evaluated in animals (4, 12 — 18), including its use to reduce circulating concentrations of brain - derived neurotrophic factor (16).

GF mice have been shown to have increased plasma tryptophan concentrations, 47, 48 which can be normalized following post-weaning colonization.47 Resident gut bacteria can utilize tryptophan for growth229 and in some cases, production of indole, 230, 231 or serotonin (reviewed by O'Mahony and colleagues95), while the microbiota might also affect tryptophan availability by influencing host enzymes responsible for its degradation.47 By limiting the availability of tryptophan for serotonin production in the CNS (EC - derived serotonin does not cross the BBB), the gut microbiota could influence serotonergic neurotransmission.95 In vulnerable populations, reducing the circulating concentrations of tryptophan has been shown to affect mood, and to reinstate depressive symptoms in patients who have successfully responded to selective serotonin reuptake inhibitors.232, 233 The gut microbiota could also influence the production of both neuroprotective and neurotoxic components of the kynurenine pathway.224

Not exact matches

«Stabilizing or reducing atmospheric carbon dioxide concentrations, therefore, requires very deep reductions in future emissions to compensate for past emissions that are still circulating in the Earth system,» the draft report says.

This would reduce the concentration of AS in the brain, but the circulating level might temporarily increase.

Individuals in the lowest tertile of circulating ANGPTL3 concentrations, compared with the highest, had reduced odds of MI (adjusted odds ratio: 0.65; 95 % confidence interval: 0.55 to 0.77; p < 0.001).

Patients with advanced AD show higher plasma but lower CSF insulin concentrations than healthy controls.40 Clearly, then, the lower concentration of insulin in the brain is not a result of reduced circulating levels in the blood.

Although leptin reduces appetite, obese individuals generally exhibit an unusually high circulating concentration of leptin.