Sentences with phrase «reduce duration risk»

Government bonds could help reduce default risk, but because of the length of maturity required to earn any meaningful yield, they do little to reduce duration risk - i.e. the overall sensitivity of a portfolio to interest rate rises.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Collins has adopted a more defensive position in the last 18 months, reducing duration and credit risk by scaling back overweight positions in high - yield and municipal bonds, but he's sticking with allocations to intermediate term funds.

We recommend that you diversify your portfolio by placing bids in different loans, with different risk bands and loan durations, to try to reduce risk by limiting your exposure to any one loan.

The short durations of these funds reduce risk, but also explain why average yields aren't higher.

It's not just about reducing interest - rate risk and duration, it's about sticking to what you are trying to achieve in your overall portfolio.

Additionally, some research suggests taking specific probiotics may support immune health and potentially reduce the risk or duration of the common cold.

Longer duration of breastfeeding may or may not affect the appearance of your breasts, but it will reduce the risk for breast cancer over your lifetime, in addition to the many other health benefits to you and to your breastfed baby.

Women who breastfeed are less likely to get breast cancer (and longer duration reduces the risk more), less ovarian cancer and osteoporosis.

Longer breastfeeding duration is further associated with reduced maternal risks of breast cancer, ovarian cancer, diabetes, hypertension, obesity, and heart attack.»

A longer duration of breastfeeding — for example more than 12 months (and this can be over several babies) is more protective, even if you are breastfeeding at all and whether you are mixed feeding with some breast milk and some formula, your breast cancer risks are reduced.

Most studies have revealed protective effects of breastfeeding on common infections in the first 8 to12 months of life.8, 27,29,30 One study, which distinguished between infectious diseases until and from the age of 6 months, revealed results similar to those from our study.24 Although the authors used exclusive breastfeeding for 3 months as the reference group, exclusive breastfeeding for 6 months reduced the risk of gastrointestinal tract infections between the ages of 3 and 6 months but not between the ages of 6 and 12 months.24 We can not explain why breastfeeding duration was only associated with lower risks of lower respiratory tract infection from 7 to 12 months.

Indeed, a long duration of breastfeeding (> 7 months) has been associated with a reduced risk of overweight and obesity, 2 while a short duration (≤ 4 months) may not be sufficient to obtain the beneficial effects of breastfeeding.3 Another confounding factor is early exposure to antibiotics, which is increasing even for minor infections.

Ollie improves the quality and duration of sleep for babies (including preemies and high risk), helps baby self - calm, and reduces colic.

Conversely, many researchers have observed a greater risk of overweight in children and adolescents who had not been breastfed compared with those who had16, 17 or who were breastfed a shorter rather than longer duration.18 — 25 On the basis of a review of 11 studies, Dewey26 concluded that «the evidence to date suggests that breastfeeding reduces the risk of child overweight to a moderate extent.»

@Just wondering: There are quite a few papers suggesting that a longer duration of breastfeeding can reduce the risk of breast cancer.

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

Moreover, although this reduced the power of the multivariate analysis, the increased risk of low MDI and total IQ scores associated with a shorter duration of breast feeding persisted after adjustment for each of the confounders, including the Raven score.

A significantly reduced risk of breast cancer was also found for those whose lifetime duration of lactation totaled 73 - 108 months (odds ratio = 0.47, 95 % CI: 0.23, 0.95) and for those who breastfed for > or = 109 months (odds ratio = 0.24, 95 % CI: 0.11, 0.53).

A recent study indicates long duration of lactation (at least 24 months) is associated with a reduced risk of heart disease in women.

«Increasing the duration of overnight fasting could be a novel strategy to reduce the risk of developing breast cancer,» said Catherine Marinac, UC San Diego doctoral candidate and first author on the paper.

Aspirin use was associated with a 47 % reduced risk of cervical cancer among frequent users — those who used aspirin seven or more times a week, regardless of duration — and 41 % reduced risk among long - term frequent users — those with five or more years of frequent use.

The ones who increased the volume and intensity of their training while reducing the duration of their sleep showed a 100 per cent rise in risk of injury.

A longer duration of treatment was significantly associated with reduced transmission risk.

Physicians can reduce ODO by implementing such measures as screening for ODO risk factors when scheduling surgery and using the shortest duration and lowest effective doses possible.

She Chairs the Scientific Advisory Board (SAB) of NASA's Translational Research Institute (TRI) at Baylor College of Medicine in Houston, charged with researching and developing innovative approaches to reduce risks to humans on long - duration exploration missions, including NASA's Journey to Mars.

Read an article about Dr. Tasali's NIH award to study pathways linking reduced sleep duration and quality to obesity risk.

But in this study, «after adjusting for age, sex, race, education, smoking, and apnea risk,» the authors note, «longer measured sleep duration was associated with reduced calcification incidence.»

The study reviewed the findings from 14 previous clinical trials that involved almost 3,000 patients and found that using echinacea reduced the risk of catching a cold by 58 percent and reduced the duration of the cold by 1.4 days.

The study revealed a significant association between duration of breastfeeding and reduced risk of diabetes, even after all other possible risk factors were accounted for.

Carbohydrate intake has been shown to reduce breath - hold durations, due to more rapid CO2 generation (because of a higher RQ) in subjects who had fasted for 18 h, suggesting that that the risk could be reduced by proper carbohydrate intake and that breath - hold diving on an empty stomach may be dangerous.»

Furthermore, our finding that obtaining an adequate sleep duration reduced overeating and consumption of fats and carbohydrates, combined with findings of reduced fat loss during a caloric restriction regimen when obtaining insufficient sleep (42) indicates clinical trials are needed to determine whether sleep is a modifiable risk factor that can assist weight loss and maintenance programs to improve dietary habits and metabolic health.

Several clinical trials that involved reductions in saturated fat in the context of reduced total fat and increased carbohydrate intake showed no CVD risk benefit, but these studies may have been limited by a small sample size and / or a limited duration of follow - up (12, 13).

Duration: Approximately 30 mins 20 slides covering: • The Male Reproductive System • The Female Reproductive System • Infectious Diseases of the Reproductive System • Bacterial Infections: Gonorrhoea • Bacterial Infections: Syphilis • Bacterial Infections: Chlamydia • Viral Infections: Genital Herpes • Viral Infections: Genital Warts • Reducing the Risk of Contracting STIs • Non-infectious Diseases of the Reproductive System • Female Cancers • Male Cancers • Treating Cancer

These risks can be reduced by computing the duration of the retirement income stream and allocating to a portfolio of inflation - protected securities that are duration - matched to the planned retirement horizon.

And so this lengthening of maturities and lengthening of duration has caused these indices to be more interest rate sensitive and some cases, more interest rate sensitive than they've historically ever been, and so by being flexible and not using that as the basis for thinking about the risk of one's investments, what you can do is reduce the interest rate sensitivity of your fixed income portfolio.

Low duration and the floating - rate structure of loans may help reduce interest - rate risk and lower portfolio volatility.

Read about how investors can use the duration of their portfolio to reduce risk.

For those clients with liability objectives, Ryan Labs manages fixed income portfolios that seek to reduce interest rate risk, tracking error, and surplus volatility versus a client's liability index or long duration benchmark relative to their liabilities.

Generally, when investors believe interest rates are going to increase, they typically shift to a lower duration strategy to potentially reduce the interest rate risk in their portfolios.

Low duration and loans» floating rate structure may help reduce interest rate risk and lower portfolio volatility.

Reducing the duration of bond exposure could help reduce rising rates risk.

On the other hand, if you wanted to reduce your risk of purchasing power loss you could buy a bond aggregate fund which pays about 2 % every year and has a duration of about 5.5 years.

Shorter duration, high - yield bonds, such as those captured in the S&P 0 - 3 Year High Yield Corporate Bond Index, are up 0.09 % MTD and 1.85 % YTD (as of March 13, 2015), as investors move down the curve in order to reduce rate volatility and term risk exposure.

If you want bonds to maximize the potential benefit, yet do so within a small bond allocation, you need to consider increasing bond duration, and reducing default risk.

The usefulness of the risk - adjusted return concept is that we can use it to evaluate a proposed strategy to determine whether it has historically been a better way to increase returns (or reduce risk) than simply adjusting any of several other well known variables (e.g., stock vs. bond allocation, duration of bond holdings, credit quality of bond holdings, etc.).

Although antibiotics may not shorten the duration of illness, they will reduce the number of bacteria excreted in the stool, thereby reducing the risk of infection to other pets or members of the household.

To reduce the risk to you, your family members and your pet, It is important for the test dog to stay on the seat for the duration of the test.

Adolescence is a critical period for the development of depression with prevalence rates rising sharply from childhood to early adulthood.1 Many adult depressive disorders have their first onset in adolescence2 with longer episode duration being the strongest predictor of future problems.3 In addition to increasing the risk of later mental health problems, adolescent depression is associated with significant educational and social impairment and is a major risk factor for suicide.1 Providing effective early interventions to shorten the duration of episodes and potentially reduce the impact on later life is therefore important.3 This study explores this question and compares the effects of...