They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation,
reduce tumor burden and prolong survival in our mouse models.»
The treatment resulted in
a reduced tumor burden and extended the lifespans of the mice by more than 30 percent.
In animal models, the modified T cells greatly
reduced the tumor burden and prolonged overall survival: All mice that received the modified T cells were alive 44 days after treatment versus 29 percent and 17 percent of the study's two control groups.
The immune checkpoint blockade drug nivolumab
reduced tumor burden in 24.4 percent of patients with metastatic bladder cancer, regardless of whether their tumors had a biomarker related to the drug's target, according to clinical trial results from The University of Texas MD Anderson Cancer Center.
The double benefit is immediately
reduced tumor burden and immunologic activation.
Not exact matches
The authors conclude, «Unvalidated guidelines to prevent neuroimaging in patients with headaches may
reduce the perceived global economic
burden at the expense of medical errors, delayed diagnoses, and inferior outcomes for patients with brain
tumor.»
The study, «Salmonella Bacterial Monotherapy
Reduces Autochthonous Prostate
Tumor Burden in the TRAMP Mouse Model,» was recently published in PLOS ONE.
In advanced mammary cancers where metastasis has occurred or in which the
tumor is fixed to the underlying tissues, surgery will not be curative but may be considered an option to
reduce local
tumor -
burden and improve quality of life.