Further advances in understanding the acquisition of magnetisation in archeo - and paleomagnetic data, continuing development of improved laboratory procedures and further investigations of suitability and appropriate scaling of sedimentary relative intensity records will help to
reduce uncertainties in the data, and consequently also in the models.
Not exact matches
These risks and
uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth
in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures
in European countries that may increase the amount of discount required on Gilead's products; an increase
in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift
in payer mix to more highly discounted payer segments and geographic regions and decreases
in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations
in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations
in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or
reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials
in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations
in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates
in the timelines currently anticipated; Gilead's ability to receive regulatory approvals
in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy
data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta
in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes
in its stock price, corporate or other market conditions; fluctuations
in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time
in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
A new integrated climate model developed by Oak Ridge National Laboratory and other institutions is designed to
reduce uncertainties in future climate predictions as it bridges Earth systems with energy and economic models and large - scale human impact
data.
A new integrated computational climate model developed to
reduce uncertainties in future climate predictions marks the first successful attempt to bridge Earth systems with energy and economic models and large - scale human impact
data.
Our new -LCB- \ em Spitzer -RCB- observations were taken two years after the original K2 discovery
data and have a significantly higher cadence, allowing us to derive improved estimates for this planet's radius, semi-major axis, and orbital period, which greatly
reduce the
uncertainty in the prediction of near future transit times for the -LCB- \ em James Webb Space Telescope -RCB--LRB--LCB- \ em JWST -RCB--RRB- observations.
Using TGAS parallaxes
in isochrone fitting we are able to
reduce distance and age estimate
uncertainties for TGAS stars for distances up to 1 kpc by more than one third, compared to results based only on spectrophotometric
data.
In their rejoinder MW claim they didn't agree with reducing the data set to 59 as follows: «the application of ad hoc methods to screen and exclude data increases model uncertainty in ways that are unmeasurable and uncorrectable.&raqu
In their rejoinder MW claim they didn't agree with
reducing the
data set to 59 as follows: «the application of ad hoc methods to screen and exclude
data increases model
uncertainty in ways that are unmeasurable and uncorrectable.&raqu
in ways that are unmeasurable and uncorrectable.»
Jane Burston, Head of the Centre for Carbon Measurement at the National Physical Laboratory, spoke to Climate Action about how the NPL is
reducing uncertainty in climate
data and helping to develop low carbon technologies.
By bringing
in a greater volume of
data, Berkeley Earth is able to significantly
reduce our
uncertainties.
In other words, the analysis neglects structural
uncertainty about the adequacy of the assumed linear model, and the parameter
uncertainty the analysis does take into account is strongly
reduced by models that are «bad» by this model -
data mismatch metric.
Data from our «eyes»
in space allow us to verify our simulations of past and current climate, which,
in turn, helps us
reduce uncertainties in projections of future climate,» said Josh Fisher, a co-author on the study who works at NASA's Jet Propulsion Laboratory
in a release.
There was a workshop on just this topic at the International Centre for Theoretical Physics
in Trieste last year «Representing and
reducing uncertainties in high - resolution proxy climate
data».
Innovative new approaches to climate
data analysis, continued improvements
in climate modeling, and instigation and maintenance of reference quality observation networks such as the U.S. Climate Reference Network (http://www.ncdc.noaa.gov/crn/) all have the potential to
reduce uncertainties.
Based on our inferred close relationship between past and future temperature evolution, our study suggests that paleo - climatic
data can help to
reduce uncertainty in future climate projections.
I fully accept we need more and better
data of the Vostok type to
reduce such
uncertainties, but
in the meantime they're the best
data we have.
Many historical
in situ marine
data still remain to be digitised and incorporated into the database, to improve coverage and
reduce the
uncertainties in our estimates of marine climatic variations.
Despite
uncertainty and confusion about the numbers, the 2016
data is one more piece of evidence that China will not return to the days of skyrocketing coal consumption for good, and that the world's largest CO2 emitter is on the right path to start
reducing its emissions permanently at some point
in the coming decade.
GIA creates
uncertainty in sea - level reconstructions based on shoreline geological
data [65], which could be
reduced via appropriately distributed field studies.
The
data generated
in this laboratory is used to
reduce the
uncertainty associated with representing the organic aerosol lifecycle
in climate models.
If not, then
in terms of systematic error, a per day
uncertainty in a physical quantity (0.2 C per reading) of a physically unique
data point can not be
reduced to a physical
uncertainty of 0.03 C merely by taking a mean of the points.
Two other important records from satellite instruments — one from MODIS and the other from MISR — don't agree well over land, so scientists hope that
data from other other sensors like SeaWiFS might help resolve some of the discrepancies and
reduce the overall
uncertainty about aerosols
in climate models.