That is why researchers more often rely on faster - developing indicators of (apparently) improved health: tumor shrinkage in cancer, lowered blood - sugar levels in diabetes,
reduced brain plaque in Alzheimer's, lowered bad cholesterol or elevated good cholesterol in heart disease.
We get heavily hyped drugs like Avastin, which shrank tumors without adding significant time to cancer patients» lives (and increased the incidence of heart failure and blood clots to boot); Avandia, which lowered blood sugar in diabetics but raised the average risk of heart attack by 43 percent; torcetrapib, which raised both good cholesterol and death rates; and Flurizan, which
reduced brain plaque but failed to slow the cognitive ravages of Alzheimer's disease before trials were finally halted in 2008.
Not exact matches
Mice that were given the drug showed
reduced plaque buildup in the
brain (a sign of Alzheimer's) and overall improved memory.
«
Brain cells from mice fed diets enriched with extra-virgin olive oil had higher levels of autophagy and
reduced levels of amyloid
plaques and phosphorylated tau,» Dr. Praticò said.
In a study published online June 21 in the Annals of Clinical and Translational Neurology, the researchers show that the consumption of extra-virgin olive oil protects memory and learning ability and
reduces the formation of amyloid - beta
plaques and neurofibrillary tangles in the
brain — classic markers of Alzheimer's disease.
But the
brains of 10 - month - old Alzheimer's mice that had a severely
reduced amount of an enzyme called BACE1 were essentially clear of new and old
plaques.
Subsequent analyses of the
brains of these animals revealed that the drug
reduced the
plaques and tangles in the hippocampus, which is known to play a key role in learning the water maze, but not in the amygdala, which figures importantly in the dark chamber test.
Combine your articles on psilocybin and other psychedelic drugs having beneficial effects on the
brain (such as 25 November 2017, p 28) with the promising reports of 40 hertz bass tones and flickering lights
reducing the tangles and
plaques of tau and amyloid proteins that are correlated with Alzheimer's disease (6 January, p 6).
Studies in mice specially bred to have features of the disease found that DHA
reduces beta - amyloid
plaques, abnormal protein deposits in the
brain that are a hallmark of Alzheimer's, although a clinical trial of DHA showed no impact on people with mild to moderate Alzheimer's disease.
Past research has focused on prevention of the disease by
reducing the levels of proteins that cause
brain plaques and tangles and kill nerve cells.
The drug also appeared to
reduce the amount of the protein amyloid beta (which forms toxic
plaques in the
brains of Alzheimer's patients) by decreasing the levels of metals such as zinc and copper.
Previously, other researchers reported that ApoE4 seemed to
reduce the clearance of amyloid - β, the protein that clumps together to form the hallmark
plaques of AD, from the
brain in a mouse model.
Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above human MLSP of around 122 years; thus these therapies do not affect epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to
reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the
Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general
brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the
brain is causal to how long we live; keeping
brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer
brain function means longer heavy
brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger
brain for their age), and both are correlated to MLSP).
Reducing progranulin markedly increased amyloid - beta
plaque deposits in the
brain as well as memory impairments.
The idea is that inhibiting Aβ formation to
reduce growth of Aβ - based
plaques in the
brains of Alzheimer's patients may be therapeutic, although it isn't yet clear how early in the disease process such an intervention would need to be employed to be effective.
The condition results from
plaque build - up, which hardens in the arteries, blocking and
reducing blood flow to the legs, arms,
brain and other organs.
Omega - 3 fats are an important type of polyunsaturated fat as they help to
reduce the risk of heart disease, lower blood pressure, guard against
plaque build - up in the arteries and aid in
brain development.
Reduced metabolic activity of
brain cells and neurons means less
brain activity and a decreased ability of the
brain to clear abnormal structures like the beta - amyloid
plaques associated with Alzheimer's disease.
It is unlikely that Aβ
plaques are a primary causative factor in AD because the effects of
reduced glucose uptake in the
brain are observed long before the
plaques are evident.
It drew mass attention when researchers were astonished to find that low doses of the golden spice significantly
reduced amyloid
plaque burden — something
brain health doctors had been seeking to do for decades.
Scientific evidence demonstrates regular exercise improves your productivity, sleep quality and blood flow to your
brain, 1 while
reducing the development of damaging neurological
plaques.2 Unfortunately, less than 25 percent of Americans over the age of 45 engage in resistance exercises, 3 which are among the most important exercises to stay fit and healthy.
High Vitamin C supplementation
reduces amyloid
plaque deposition (cause of AD), blood
brain barrier disruptions and mitochondrial dysfunction in the
brains.
It
reduces one of the main factors of memory loss...
Brain plaque.
And, coenzyme Q10
reduces amyloid
plaque in the
brain, helping to prevent — and even reverse — Alzheimer's disease.
Able to slow cognitive decline, BIIB037, or aducanumab, works by «
reducing amyloid
plaques in the
brains of people with dementia.»