Sentences with phrase «reduced cell activity»

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In the lab, they also did an experiment to see if wash water from tunnels affected the protein activity in liver cells, or reduced the growth of an algae called Pseudokirchneriella subcapitata.

University of Washington researchers have found that a calorie - restricted diet reduces the activity of a cell - signaling protein called TOR - 1 that may speed up cell aging.

Professor Rudi Beyaert (VIB / UGent): «We found that pharmacological treatment of human skin cells with drugs that inhibit the activity of MALT1 reduced the production of inflammation promoting proteins caused by mutant variants of CARD14.

Research shows that it improves memory and sleep, boosts immune cell activity and reduces viral load in AIDS patients, and even speeds healing after surgery.

Maria Braga, DDS, PhD, and colleagues at the Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, found that activating ASIC1a decreased the activity of nearby cells and reduced anxiety - like behavior in animals.

Depending on the current, the wires can either boost activity in nearby brain cells or reduce it.

In further work, a drug that blocks FAK reduced the formation of mammospheres, or clumps of breast cancer stem cells, showing FAK is important in cancer stem cell activity.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

«We have shown that blocking the activity of FAK not only reduces the growth of breast cancer stem cells, but also improves sensitivity to radiotherapy.

Our results suggest that frequent overexpression of Aurora Kinase in cancer may reduce RUNX3 transcription activity, leading to cell division and formation of tumours.

«If immune cell therapies for cancer or autoimmune diseases (like rheumatoid arthritis, for example) are going to be safe and effective alternatives to more traditional medications, we must gain control over the activity of the cells to reduce risks of toxicity to the patient,» said Roybal.

Natural killer cell activity was markedly reduced but inducible.

The liver cells transfected with an HCV internal ribosome entry site (IRES)- driven luciferase reporter that were treated with SBEL1 reduced reporter activity by 50 % compared to control.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

A cell that is in stress reduces its activity in order to survive with the goal of restoring it to a normal condition after the stress passes.

«If you can use combination approaches, hitting multiple targets within the cell to reduce the activity of each, and you see a synergistic effect between them, you may be able to overcome some of their harmful effects in HER2 - positive cancer, and perhaps also resistance,» says Tonks.

When a cell faces such metabolic stress, it is logical that it will reduce its activity level in order to survive.

Reducing sedentary activity appears to lengthen telomeres, which sit on the end of chromosomes, the DNA storage units in each cell, the findings show.

Viral infections simultaneously reduce the amount of nutrients and materials available to larger organisms by killing microbial cells, but also stimulate microbial activity through the release of organic matter and nutrients, which provides increased biomass available for larger organisms including fish.»

«Inhibiting DGKi seems to reverse the effects of cystic fibrosis, but not block ENaC completely,» says Margarida Amaral from the University of Lisboa, «indeed, inhibiting DGKi reduces ENaC activity enough for cells to go back to normal, but not so much that they cause other problems, like pulmonary oedema.»

The group took the first step toward their goal of a novel engineering strategy for yeast by creating what is known as a cDNA library: a collection of over 90 % of the genes from the genome of baker's yeast (Saccharomyces cerevisiae), arranged within a custom segment of DNA so that each gene will be, in one version, overactive within a yeast cell, and in a second version, reduced in activity.

The virus reduces this activity, killing cancer cells.

They assessed gene activity at time points known to correspond with key phases of disease: the «induction phase,» the time before the peak level of photoreceptor cell death; the «execution phase,» when the highest rates of photoreceptor cell death occur; and the «chronic phase,» during which photoreceptor cell death continues at somewhat reduced levels.

Previous studies suggest that microgravity activates osteoclasts, cells that control the breakdown of bone tissue, and the Medaka fish investigation examined the relationship between this increased osteoclast activity and reduced bone mineral density.

Reduced mitochondrial activity is associated to altered mitochondrial dynamics in Down syndrome cells

E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells, reports a new study, published in PNAS.

Future therapies will have to be based on strategies that act by reducing or increasing the number or activity of specific subtypes of pre - and postsynaptic receptors, transporters, and ion channels, or other membrane molecules at the synapse, and by strategies that exploit the new possibilities offered by stem cell technology and targeted repair.

Reduced phosphodiesterase 3 activity and phosphodiesterase 3A level in synthetic vascular smooth muscle cells: implications for use of phosphodiesterase 3 inhibitors in cardiovascular tissues.

Interfering in this pathway via any of the related proteins so as to reduce TGF - β1 levels may be a viable way to increase stem cell activity in later life.

The present study shows that the basal glucose uptake as well as insulin - stimulated GS activity is reduced in satellite cell cultures established from patients with type 2 diabetes.

This team plans to conduct the first human clinical trial combining these two therapeutic strategies (which have been tested separately and have shown activity in reducing HIV in humans), with the expectation that a boosted innate immune system empowered with unique antibodies to target HIV - infected cells will achieve greater reductions in HIV than observe previously.

In genetically programed insulin - resistant obese mice with increased appetite and reduced physical activity, targeted restoration of Pomc function only within 5 - hydroxytryptamine 2c receptor containing cells induces sex differences in energy balance (267).

But macrophages from older mice acted differently: A-beta's presence incited a big increase in EP2 activity in these cells, resulting in amped - up output of inflammatory molecules and reduced generation of recruiting chemicals and A-beta-digesting enzymes.

The decreased glucose transport in diabetic cultures will decrease the intracellular glucose and G6P content, but because the GS activity is also reduced, it is possible to obtain G6P concentrations that are nearly identical in control and type 2 diabetic cell cultures.

Reducing NF - kB activity in immune cells yielded another important result.

When the correlation is absent, a reduced meristematic activity drives an extremely faster root growth, with very long mature cells (Fig 4F and H).

Consequently, we found that si - IRF - 1 could significantly reduce IFNα - induced luciferase activity in STAT1 - transfected U3A cells (Fig. 4A), showing that IRF - 1 was indeed involved in transcriptional activation of RIG - G.

Moreover IL - 7 reduces the suppressive activity of regulatory T cells.

Knocking out or blocking the activity of Nrp1 on regulatory T cells in mouse models of several human cancers, including the deadly skin cancer melanoma, led to reduced, delayed or complete elimination of the tumors.

This is associated with a relative reduction in cytotoxic T - cell activity and a reduced capacity to destroy infected host cells and clear the virus from infected lung tissue.

Mesenchymal Stem Cells Require CD73 Activity to Reduce Leukocyte Associated Inflammation Following Myocardial Ischemia - Reperfusion Injury

His studies, ranging from molecular experiments to clinical trials, have generated comprehensive evidence for the efficacy of omega - 3 in preventing cardiac sudden death and established the mechanism by which omega - 3 fatty acids can reduce cardiac arrhythmia by interacting with membrane ion channels and stabilizing the electrical activity of heart cells.

established that MAO loss led to prostate atrophy with reduced prostate basal and stem / progenitor cell activity in adult mice, thereby providing insight into the maintenance of prostate structure and function.

Reduced expression of Paternally Expressed Gene - 3 enhances somatic cell reprogramming through mitochondrial activity perturbation, Scientific Reports.

Moreover, the authors demonstrated that 600 - day - old S6k1 — / — mutants showed improvement in several aging - associated phenotypes, such as impaired motor coordination, reduced exploratory activity, reduced bone volume, and elevated CD44 + T cell counts (45).

In a series of electrophysiological studies, Zoghbi's team further found that neurons from animals with depleted MECP2 levels have reduced electrical activity due to a smaller number of excitatory synapses, whereas cells from animals carrying an extra copy of the gene have increased electrical activity because of an increase in synapse number.

Due to reduced mTOR activity, a key intracellular signaling pathway regulator, the function of the cell's power plants, the mitochondria, is disrupted.

Exposure to common food additive carrageenan leads to reduced sulfatase activity and increase in sulfated glycosaminoglycans in human epithelial cells Check out this book: Excitotoxins: The Taste That Kills

When you get enough dietary protein, it reduces the activity of a complex inside cells called ubiquitin proteasome system.

1) Phytonutrients: * Occur naturally in fruits and vegetables * Promote the function of the immune system * Help fight off viruses as well as reduce inflammation * Associated with the treatment and / or prevention of cancer and cardiovascular disease 2) Enzymes: * Responsible for metabolic processes that occur within a cell and are necessary for sustaining life * Assist and play a large role in digestion, energy production, blood coagulation and contraction of muscles 3) Amino Acids: * The basic building blocks of protein * Absorption of amino acids is essential for your metabolism 4) Essential Fatty Acids: * Reduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones andreduce inflammation * Associated with the treatment and / or prevention of cancer and cardiovascular disease 2) Enzymes: * Responsible for metabolic processes that occur within a cell and are necessary for sustaining life * Assist and play a large role in digestion, energy production, blood coagulation and contraction of muscles 3) Amino Acids: * The basic building blocks of protein * Absorption of amino acids is essential for your metabolism 4) Essential Fatty Acids: * Reduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones andReduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones and teeth