Sentences with phrase «reduced cell proliferation»

We also demonstrate that ACTB haploinsufficiency leads to reduced cell proliferation, altered expression of cell - cycle genes, and decreased amounts of nuclear, but not cytoplasmic, β - actin.

Not exact matches

High dosages of reb A fed to rats reduced sperm production and increased cell proliferation in their testicles; however, another study using rats and humans demonstrated lack of reproductive toxicity.

Acute Psychosocial Stress Reduces Cell Survival in Adult Hippocampal Neurogenesis without Altering Proliferation.

In the paper, the researchers show for the first time that ANG simultaneously reduces proliferation of stem cells and promotes proliferation of myeloid progenitor cells that give rise to mature myeloid cells.

Through these effects, the PERY peptide reduced the proliferation of several (but not all) cancer cell lines in culture and inhibited the growth of a human breast cancer xenograft in mice.

Mammalian hairs and avian feathers develop from a similar primordial structure called a «placode»: a local thickening of the epidermis with columnar cells that reduce their rate of proliferation and express very specific genes.

Overall, the presence of B lymphocytes was associated with increased tissue proliferation, reduced cell death and a more supportive environment for wound healing.

Treatment of vestibular schwannoma cells with mifepristone reduced their proliferation rate by 80 percent.

In their models, abatacept reduced the proliferation and activation of effector T cells.

An experimental drug that targets abnormally high levels of a protein linked to cancer growth appears to significantly reduce the proliferation of prostate cancer cells in laboratory cell cultures and animals, while also making these cells considerably more vulnerable to radiation, according to results of a study led by Johns Hopkins scientists.

Furthermore, when they blocked the action of the gene using RNA interference, the cell proliferation index was reduced.

Overexpression of GARP reduced the proliferation and activation of B cells.

Furthermore, when the team suppressed STAP - 2, the prostate cancer cells showed reduced proliferation and did not form a tumor when transplanted into mice.

Changes in chromatin may help reduce unwanted stem cell proliferation and can be achieved by adding drugs to experimental cultures in Petri dishes, Kwan said.

The pathway then uses the tumor's metabolism to break down glucose and use its energy to reduce cell death and maintain proliferation.

Specifically, it reduces the production of inflammatory compounds like prostaglandins, slows white blood cell proliferation and even kick - starts apoptosis in existing white blood cells, causing them to break down.

Satellite cell proliferation is reduced in muscles of obese Zucker rats, but restored with loading.

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells.

Insulin is a key ingredient for the growth and proliferation of normal stem cells, and the study demonstrated that insulin resistance also reduces the ability of the iPSCs to grow and proliferate.

In search of a mechanism behind the finding that HIV / gp120 reduced proliferation of aNPCs, the scientists studied the effect of the protein on the cell cycle.

This supported work from Bartholomew et al 120 showing that the addition of IL - 2 to MLR / MSC co-cultures reduced MSC suppression and restored T cell proliferation.

MSCs impair the differentiation of monocytes or CD34 + HSCs into DCs by inhibiting the response of the former to maturation signals, reducing the expression of co-stimulatory molecules and hampering the ability of the former to stimulate naive T cell proliferation and IL - 12 secretion 33, 34, 35.

Various studies demonstrated that stem cells treatment reduced scar burden, affected fibroblast proliferation, reduced Type I and Type III Collagen synthesis, improved ventricular function and affected left ventricular geometry.

The Zika virus is known to negatively impact the growth of fetal brains and a group of researchers publishing in the journal Cell Stem Cell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferatCell Stem Cell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferatCell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferatcell death and reduced proliferation.

In human gastric tissue, however, gastric epithelial cell proliferation is significantly higher but apoptotic indices are lower among persons colonized with cag + compared to cag - strains or uninfected persons leading us to postulate that reduced rates of cell loss, when accompanied by hyperproliferation, may heighten retention of mutagenized cells, which could predispose towards cancer.

Inhibition of Notch signaling reduces proliferation of stem cells, induces cell death, and down - regulates non-canonical Wnt5a, suggesting that the Notch pathway contributes to maintenance and motility of the stem cells.

Their limited proliferation capacity makes it necessary to prepare MEF cells often, creating batch - to - batch variability and reducing reproducibility in derivation of iPS cells.

We observe that a stress of 10 kPa is sufficient to drastically reduce growth by inhibition of cell proliferation mainly in the core of the spheroid.

The drug greatly reduced cancer cell proliferation and survival.

In mice, which are mammals like humans, MSI - 1436 improved heart function, increased survival, reduced scarring and stimulated the proliferation of heart muscle cells.

Our biological studies suggest that a critically reduced amount of this protein alters cell shape, migration, proliferation, and gene expression to the detriment of brain, heart, and kidney development.

Coal - tar shampoos ($ 19; amazon.com) slow the proliferation of skin cells and reduce inflammation, especially for mild scalp psoriasis.

Studies (like this one) have even demonstrated a reduced proliferation of cancer cells in subjects who practiced intermittent fasting, and another study showed that alternate day fasting led to better reception of chemotherapy in cancer patients and a higher cure rate.

Acai containing polyphenolics could reduce proliferation of HL - 60 leukemia cells in vitro.

Sesamol has been shown to inhibit melanin synthesis in mouse melanoma cells, resulting in reduced viability and proliferation of the cells.

Both antioxidant compounds work reducing the proliferation of reactive oxygen species in cells, preventing mutations and dead due to oxidative stress.

The apple extracts with skin significantly reduced the tumor cell proliferation when compared with the apple extracts without skin.

Research has shown that Dulse extracts inhibited HeLa cell proliferation that is found in human cervical adenocarcinoma and has also been found to reduce the risk of intestinal cancer and breast cancer, or mammary cancer.

Green tea reduces C - reactive protein and green tea catechins can successfully banish cancer cells, by slowing metastasis, inhibiting cell proliferation and inducing apoptosis.

These include a reduction in B cell differentiation to plasma cells and a reduced proliferation of T cells.

This disease - fighting nutrient can slow the growth and development of new blood vessels that nourish tumors, increase a type of programmed cancer cell death known as apoptosis and reduce the proliferation of new cancer cells.

Curcumin — Improves * detoxification of oestrogen by supporting safe, tissue - protective oestrogen metabolite, reduces * oxidative damage, inhibition of the growth of breast cancer cells [2] Lycopene - Powerful antioxidant, inhibition of cancer cell proliferation [3], reduction * of DNA damage from estrogen [4],

The clove treatment was found to significantly reduce hepatic cell proliferation and processes involved in liver cirrhosis.

However, evidence suggests that by systematically reducing the amount of dietary carbohydrates, one could suppress, or at least delay, the emergence of cancer, and that proliferation of already existing tumor cells could be slowed down.