Sentences with phrase «reduced heterozygosity»

In another study, there was little correlation between current levels of inbreeding or reduced heterozygosity and prevalence of genetic disease [19].

Absence or reduced heterozygosity means that a patient's genome contains long stretches of homozygosity, which can be problematic if that region harbors a variant in an autosomal recessive disease gene.

Not exact matches

Therefore, reducing genome heterozygosity through inbreeding is an effective strategy for acquiring high - quality draft genomes of non-model organisms.

This could result in a reduced gene pool and reduced genetic heterozygosity leading to other potential health risks.

Undoubtedly outcrossing will increase heterozygosity and reduce the frequency of disease - causing alleles in a breed.

Reduced allelic diversity and heterozygosity are expected consequences of founder effects, genetic drift, and inbreeding, which are associated with colonization and subsequent small population size (Frankham 1997, 1998).