Sentences with phrase «reduced hippocampal»

[17] Hayes, J. P., et al. «Reduced Hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat - related PTSD.»

While animal data would suggest that institutional rearing would lead to reduced hippocampal volume, some investigators have suggested that such effects may not become evident in humans until later in life.18 Consistent with this, decreased hippocampal volumes have been found in numerous studies of adults who experienced high levels of childhood stress / trauma.19, 20 In spite of this hypothesized delayed hippocampal effect, a positive impact of early supportive parenting on hippocampal development has been detected as early as school age.21

Adult mice maintained on a high - fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression.

Reduced hippocampal volume and lower cortisol response to stressors have been demonstrated as features of and risk factors for PTSD, Raper says.

Massaad, C.A., Washington, T.M., Pautler, R.G., and Klann, E. (2009) Overexpression of SOD - 2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease.

Not exact matches

Acute Psychosocial Stress Reduces Cell Survival in Adult Hippocampal Neurogenesis without Altering Proliferation.

Volumes of other CA areas and hippocampal tail were more reduced in subjects who had more manic episodes.

The anti-anxiety reducing effects of metformin during nicotine withdrawal are dependent on hippocampal AMPK?.

Consistent with reduced levels of postnatal hippocampal neurogenesis, infant guinea pigs and degus did not exhibit forgetting.

SR - / - mice had reduced dendritic spines and hippocampal volume.

The anti-anxiety reducing effects of metformin during nicotine withdrawal are dependent on hippocampal AMPKα.

Discovered that the persistent sodium current, INaP, paradoxically amplifies afterhyperpolarizations and reduces the frequency (f / I) gain, and strongly modulates spike timing (Vervaeke et al., Neuron 2006); that Kv7 / M / KCNQ - type K + channels but not SK channels are essential for excitability control in hippocampal neurons (Gu et al., J Physiol, 2005); that Kv7 / M / KCNQ - type K + channels are essential for spatial learning and prevention of epilepsy (Nature Neuroscience 8: 51 - 60, 2005), that KCa1 / BK - type K + channels are essential for cerebellar learning and motor control (Proc Natl Acad Sci USA 101: 0474 - 8, 2004), the role of postsynaptic voltage-gated K + channels in regulation of synaptic plasticity (LTP) and integration (Proc Natl Acad Sci USA 99:10144, 2002); that Kv7 / M / KCNQ - type K + channels are essential for intrinsic theta resonance in hippocampal neurons (J Physiol 545:783, 2002).

Together, both compounds can effectively reduce oxidation and protect hippocampal cells from toxicity.

ApoE genotype influences insulin degrading enzyme production, with E4 homozygotes expressing 50 percent less hippocampal IDE than non-E4 carriers.27 It is not known whether the ApoE4 genotype causes reduced IDE.

In addition to the hippocampal changes, both sugar and stress produced increased levels of the stress hormone cortisol, as well as reduced the expression of genes needed for nerve growth.

In addition to their ability to maintain sensitivity to unexpected events against a background of expected stressors, Novel rats also exhibit reduced emotional reactivity measured in the open field (11, 22), enhanced HPA negative feedback control as indicated by a greater CORT suppression of hippocampal field potentials (23), and a reduced basal CORT concentration (13).

Also, people with low self - esteem and depression react with more stress in several stressful situations, secretion of cortisol in their blood is higher and their hippocampal volume is reduced (Orth, Robins, Widaman, & Conger, 2014).