Sentences with phrase «reduced immune response»

The long - chain lipoproteins on S. aureus led to a considerably reduced immune response, both in the innate and the adaptive immune system; while the short - chain lipoproteins on S. carnosus set off an immune response which was almost ten times stronger.

Without the regulatory influence of PD - 1, the over activated and over stimulated T cells result in disruption of a crucial balance between different T cell types that leads to an overall greatly reduced immune response.

He found that very young children exposed to the chemical have a reduced immune response to vaccinations.

The discovery suggests that European populations have been selected to display reduced immune responses since our ancestors first made their way out of Africa.

Although this increase is not enough to be life - threatening, such changes can be associated with feelings of anxiety, and with alterations to the hormonal system that can reduce immune responses.

The authors suggest the mechanism behind this effect is the immunomodulatory effect of antibiotics, and the disruption of the microorganisms (microbiome) in the gut caused by antibiotics which can lead to reduce immune responses.

In asthma there is a constriction of the airways and an increase in immune activation — typically these are treated with a dilator (salbutamol) and a steroid (to reduce immune response).

Corticosteroid and immunosuppressant therapies are commonly prescribed to reduce the immune response.

Mushrooms are living organisms and as such, they intelligently modulate the immune system and help reduce the immune response when it's overrun as in the case of chronic inflammation.

Not exact matches

Beta - carotene has been found to reduce cell damage caused by free radicals, and improves immune function by enhancing cell mediated immune responses.

McKenna wrote, «Irrepressible (ancient) neurologically - based infant responses to maternal smells, movements and touch altogether reduce infant crying while positively regulating infant breathing, body temperature, absorption of calories, stress hormone levels, immune status, and oxygenation.»

Instead, irrepressible (ancient) neurologically - based infant responses to maternal smells, movements and touch altogether reduce infant crying while positively regulating infant breathing, body temperature, absorption of calories, stress hormone levels, immune status, and oxygenation.

In addition to being more highly exposed to As, children appear to be far more sensitive to the potential carcinogenic effects of As49, 50 and have a heightened risk for adverse growth, adverse immune response, and adverse neurodevelopmental outcomes,25,51 - 53 even at relatively low levels of exposure.24, 54 Our results indicate that consumption of rice and rice products increases infants» exposure to As and that regulation could reduce As exposure during this critical phase of development.

Others are trying to reduce overzealous immune responses that take their toll through inflammation - related ailments like heart disease, arthritis, Alzheimer's disease, and cancers.

Assembling mRNA using pseudouridine, a nucleoside variant that occurs naturally in the body, greatly reduced the tendency of immune sentinels called dendritic cells to shoot out inflammatory molecules in response, they reported in 2005.

«We are pleased to have demonstrated such a potent and durable immune response to the vaccine,» said the study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found effective in clinical trials, the vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections as well, especially in high - burden regions of sub-Saharan Africa.»

«We also found that reduced cohesin led to changes in the expression of genes involved in nerve cell development and the response to an immune signaling protein,» corresponding author Toshihide Yamashita says.

The reason for the reduced glucose levels associated with bacterial meningitis was believed to be the need for glucose as fuel by infiltrating immune cells in response to infection.

Along with improved potency and safety, the system saves time by providing easy, ready - touse RNA reagents that also reduce cell toxicity by avoiding activation of cellular innate immune responses.

While adjuvants improved the immune response to vaccinations in both lean and obese mice, the overall immune response was reduced in the obese animals compared to their lean counterparts.

Adjuvants can stretch the amount of vaccine made from a given amount of viral protein and reduce the number of shots needed to trigger an effective immune response.

Conversely, the immune system contains triggers to blunt immune responses, and antibodies that block these «off - switch» checkpoints might be able to further reduce the ability of these cancers to escape the immune system.

At the same time their skeletal muscle ramps up production of an immune molecule that increases their response to insulin, resulting in reduced circulating insulin levels, protection against type 2 diabetes and longer lifespan.

The first enzyme reduces the body's ability to mount an immune response against infection.

«Additionally, the development of immune response against WNV may have reduced human cases by depleting the susceptible human population.

The combination of these two aspects of the immune response reduce risk of recurrence and discourage spreading or metastasis of the cancer.

Analyses of RV144 volunteers revealed that particular vaccine - induced immune responses, including production of certain antiviral antibodies and CD4 + T cell responses to HIV's outer shell, or envelope, correlate with reduced HIV infection.

These animals had severely reduced T and B cell immune responses.

«Although data clearly indicate better immune responses and vaccine efficacy against both genital warts and cervical dysplasia when vaccination occurs before age 14, this study suggests that HPV vaccination may be effective in reducing abnormal Pap test results even after sexual debut,» explained co-author Rebecca Perkins, MD, MSc, assistant professor of Obstetrics and Gynecology at Boston University School of Medicine and a gynecologist at Boston Medical Center.

A possible problem facing a human vaccine is that some people already have an immune response to some strains of adenoviruses, which would reduce the body's response to the vaccine strain.

However, the treatment did significantly reduce the severity of the asthma by counteracting one aspect of the specific immune response in the lungs.

«Controlling and successfully balancing the immune response following Ebola virus infection is greatly important for reducing symptoms and fatal outcomes,» said Mathieu Iampietro, the co-lead author of the paper.

While the observed differences of the individual steps were mostly modest, mathematical modeling suggested that even small delays in the trafficking of these immune cells will lead to reduced initiation of a WNV - specific antibody - response during the early stages after infection.

«Adenosine deaminase may help the immune system fight HIV on its own: Adenosine deaminase enhances anti-HIV-1 specific immune responses by reducing the action of cells that impede HIV - specific defenses.»

14 Holding hands and kissing reduces levels of the stress hormone cortisol, thereby lowering blood pressure and optimizing immune response.

A new study in animals shows that using a compound to block the body's immune response greatly reduces disability after a stroke.

Without Caveolin - 1, the binding of viruses or bacteria to the B cell results in a reduced activation signal, which leads to a weakened immune response.

DHCA reduces interleukin 6 (IL - 6), a pro-inflammatory substance secreted by T cells and macrophages to stimulate immune response, by epigenetically modulating the non-coding sequence of the IL - 6 gene.

New research shows that chronic stress suppresses the immune system's response to cancer, reducing the effectiveness of immunotherapy treatments.

«For example, restoring the lost enzymes in the two metabolic pathways might slow tumor progression and reduce aggressiveness by inactivating oncogenic kinases and activating immune responses,» says Chakravarti, who holds the Max Morehouse Chair in Cancer Research.

The study identified that nociceptin has substantial activity in asthma models given before or during an asthma attack — and that a single molecule reduces both the immune response and causes dilation.

Vaccinating older individuals is problematic, as the effectiveness of most vaccines decrease with age, with maximal responses often as low as 30 % in the over 70s.5 Nevertheless, vaccination programmes demonstrate the ability to reduce disease burden in the elderly as well as offering a tool to observe immune responses in vivo in humans.

If the patient is able to mount a strong immune response that controls virus replication they can ultimately reduce the level of virus in their blood to a level beyond detection, effectively zero for clinical purposes.

To be certain the Th2 type immunopathology was elicited by the S protein vaccine in our studies and in hopes a greater immune response would result from higher dosages of the vaccine and induce greater protection against infection as well as reduce or prevent the immunopathology, our experiment 2 used up to 9 µg of the S protein for immunization.

A number of studies reported that HDAC inhibitors could suppress the immune response of T cells and reduce the severity of inflammation and, therefore, might be used to inhibit immune rejection or induce tolerance in organ transplantation and BMT (20 — 23).

Reduced IL - 22 in both the inflammatory milieu and systemically would have far reaching effects on the effectiveness of the immune response to combat infection.

The unique blend of stem and regenerative cells found in your fat tissue has demonstrated remarkable effectiveness in halting destructive immune response, restoring function by providing cellular - level repair of damage, increasing blood flow and reducing inflammation.

The «reduce and control» strategy involves decreasing the size of HIV reservoirs while engineering an immune response to control the remaining virus.

We found that old animals bearing CD8 + TCE within Vbeta10 or Vbeta8 families failed to mount an effective immune response against HSV - 1, as judged by reduced numbers of peptide - major histocompatibility complex tetramer + CD8 T cells and an absence of antiviral lytic function.

Stimulation of gamma waves reduced levels of amyloid - β, decreased phosphorylation of tau, and led the brain's immune cells — microglia — to perform their usual housekeeping role, clearing away cellular debris, including amyloid - β (as opposed mounting an inflammatory response as microglia do in Alzheimer's disease, Tanzi explained).