Sentences with phrase «reduced numbers of cells»

Our conclusion that LFA1 and ICAM1 function during innate - like lymphocyte movement from the SCS into the LN parenchyma is based on four sets of observations in mice treated with αL blocking antibody: (1) innate - like lymphocytes transiently accumulate in the SCS; (2) the accumulated cells exhibit an unusual elongated morphology (suggesting a less adhesive state); (3) tracking analysis shows reduced numbers of cells migrating from the SCS into the parenchyma; (4) the cells are more sensitive to dislodgement by CD169 blocking antibody.

Human tissues exposed to either drug for one week in a dish had reduced numbers of cells that give rise to sperm and eggs, called germ cells, the study found.

Knowing which cells are best for the therapy should not only improve patient outcome, but also reduce the number of cells required, which would further reduce both the time of the preparation and invasiveness of the procedure.

There are many types, and certain cancer treatments (including chemotherapy) reduce the number of these cells.

This correction would increase R2 by reducing the number of cells that have changed climate type.

Not exact matches

A series of preliminary Mayo Clinic studies conducted in 2010 showed promise for the potential use of a chemical component of green tea (epigallocatechin gallate) in reducing the number of cancer cells in patients with chronic lymphocytic leukemia.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Eggplant is loaded with phytonutrients that act as antioxidants that help to reduce the number of free radicals in the body which damage cells and may contribute to certain diseases, including some cancers and heart diseases.

It successfully reduced the number of inflammatory cells in the eye, the study said.

«Our work predicts that reducing the number of circulating cancer cells produces less metastasis,» Pellecchia said.

Liposuction is the only way to actually reduce the number of fat cells in your spare tire.

If researchers could reduce the loss of cells, they could one day treat two or even three times as many patients from the limited number of cadaver donors available, García noted.

Expression of CXCL16 was higher in the colon and lung tissue of GF mice than in normal mice, and blocking that expression reduced the numbers of iNKT cells and the amount of inflammation in those tissues.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

Compared with a normal mouse cochlea (top), cisplatin exposure reduces the number of outer hair cells (middle).

Not only that, the number of key cells in the basal forebrain — which plays an important role in learning and memory — are reduced when ovaries are removed.

Last month, however, researchers led by Samuel Charache of Johns Hopkins University School of Medicine in Baltimore announced that they have devised a way to reduce the number of sickle cells in the body.

However, Feske and his colleagues found that calcium signals also are required for the development of iTreg cells and that their numbers are strongly reduced in the lungs of the infected STIM1 - deficient mice.

Proteins called kinesins, for example, are natural nanomotors that support cellular functions such as mitosis (the chromosomal process that creates two nuclei from one parent nucleus) and meiosis (when the number of chromosomes per cell is reduced by one half).

Age - related decline of neurogenesis and cognitive function is associated with reduced blood flow and decreased numbers of neural stem cells.

On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.

B cell treatment also quickly reduced the size and improved the healing of chronic skin ulcers in the diabetic mice, increasing the number of both nerve endings and blood vessels in regenerated tissue.

The new perovskite solar cells have achieved an efficiency of 20.1 per cent and can be manufactured at low temperatures, which reduces the cost and expands the number of possible applications.

He then describes a hypothesis that vaccines reduce allergies by boosting type 1 helper T - cells, reducing the number of type 2, which are geared to fight parasitic worms in the gut and are associated with allergies.

Stress can cause changes in the function of the immune system, including reducing the number of natural killer cells that are known to battle cancer.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

«A number of tests demonstrated that these artificially created cells had all of the properties of the affected nerves, including the calcium imbalance and reduced energy production observed in patients.

Numbers of migrating cells, shown in red, are greatly reduced when the molecule FOX01 is deleted (right column).

Besides the reduced numbers of helper T cells in the DLNs, the researchers also found that the lymph node environment in older mice contained lower levels of immune stimulators (so - called chemokines) and therefore was less capable of attracting other immune cells necessary for germinal center formation.

The most common blood disorder is anemia which reduces the number of red blood cells, hampering the ability of blood to carry oxygen.

Introducing substances into the postsynaptic cell that block membrane fusion at a number of different steps reduced LTP.

If the cells reduce the copy number of this specific chromosome again — say upon another change in environmental conditions — then they turn back into a smooth colony.

«The collapse of the CD4 + T - cell system is the cardinal feature of AIDS,» Goldsmith observes, «so understanding which subsets of T cells can be infected is important in providing a clear picture of how HIV reduces the number of T cells.»

As the researchers have shown in various studies on mice, the widespread active ingredient sildenafil or a medication against pulmonary hypertension, for instance, can be used to reduce the number of white fat cells to the benefit of the brown fat cells and thus accelerate fat burning like a turbocharger.

Selective immunoproteasome inhibition using the inhibitor ONX 0914 reduced the number of B cells and plasma cells and suppressed donor - specific allo - antibody production.

The scientists discovered that the receptor helped regulate metabolic processes that control body weight, and reducing the number of p75 NTR in fat cells prevented weight gain in mice.

Previous brain autopsies have shown that patients with TSC, as well as patients with ASD, have reduced numbers of Purkinje cells, the main type of neuron that communicates out of the cerebellum.

They then tested the effect of a second drug molecule called misoprostol, which also interacts with EP4, and showed that misoprostol also has the ability to combine with TKI and significantly reduce the number of leukemia stem cells.

As might be expected, it reduces the number of bone - dissolving cells, or osteoclasts, in mice with a condition resembling osteoporosis.

Although muscle cells did not reduce in size or number in mice lacking a protective antioxidant protein, they were weaker than normal muscle cells, researchers from the Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center San Antonio found.

The reduced numbers of bacteria and white blood cells resulted in less lung damage in the older mice who received extra vitamin E.

The drug, called SelG1, also reduced the frequency of pain crises in people with sickle cell disease and reduced the number of days they spent in the hospital.

Immune cells that specialize in defending these areas may get some prompting from IL - 34, the researchers speculate, but the numbers of these cells were not significantly reduced when IL - 34 was knocked out, suggesting that other molecules can perform the same function for those cells.

The first reports that gene - editing of bone marrow stem cells in monkeys infected with a variant of simian immunodeficiency virus (SIV) significantly reduces the number of dormant «viral reservoirs» that pose a risk of reactivation.

Future therapies will have to be based on strategies that act by reducing or increasing the number or activity of specific subtypes of pre - and postsynaptic receptors, transporters, and ion channels, or other membrane molecules at the synapse, and by strategies that exploit the new possibilities offered by stem cell technology and targeted repair.

h) Graph showing reduced number of spheres formed in siTRF2 silenced cells after 7 days post silencing as compared to Scrambled transfected HCT116 (p < 0.05).

We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host - cell transformation, and a Theileria - specific protein domain [frequently associated in Theileria (FAINT)-RSB- present in a large number of secreted proteins.

The first reports that gene - editing of bone marrow stem cells in monkeys infected with a variant of simian immunodeficiency virus (SIV) significantly reduces the number Read more about Gene - editing and vaccines could improve HIV treatment - Scimex

The use of human embryonic stem cells, as opposed to patient blood, as the starting material for AST - VAC2 provides a scalable system for the production of a large number of vaccine doses in a single lot, reducing manufacturing costs, enabling «off - the - shelf» availability, and ensuring product consistency.

A number of studies reported that HDAC inhibitors could suppress the immune response of T cells and reduce the severity of inflammation and, therefore, might be used to inhibit immune rejection or induce tolerance in organ transplantation and BMT (20 — 23).