Sentences with phrase «reduced production of a protein»

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

This shift in nitrogen disposal effectively reduces the production of these protein - bound toxins.

Not exact matches

With proteins coming under scrutiny for their high ecological impacts, approaches to reduce environmental impacts of livestock and seafood production will be discussed.

Navarro said that because the ingredient is a highly performing texturizer it also significantly reduces the cost of production by decreasing the need for milk proteins.

The disruption of the microbiome reduced production of a key cellular protein vital to the barrier's effectiveness.

Professor Rudi Beyaert (VIB / UGent): «We found that pharmacological treatment of human skin cells with drugs that inhibit the activity of MALT1 reduced the production of inflammation promoting proteins caused by mutant variants of CARD14.

«Reducing protein production in aging neurons allows more energy for the cell to put toward folding proteins correctly and handling stress,» says Zheng, the first author of the new paper.

Like removing unnecessary lighting from a financially strapped household to save on electricity bills, the drug — called rapamycin — prolongs the survival of diseased neurons by forcing them to reduce protein production to conserve cellular energy.

DeltaFosB has a relatively long half - life, therefore even when seizures are infrequent, deltaFosB remains in the hippocampus for weeks acting like a brake, reducing the production of calbindin and other proteins, and disrupting the consequent brain activity involved in memory.

In the study, which was published online in the Annals of Neurology, the scientists reduced the level of the protein tau by genetically engineering Dravet mouse models, «knocking out» the gene associated with tau production.

IL - 1β was reducing the production of tight - junction proteins, which are crucial to making the intestinal barrier impermeable to pathogens.

The analysis also showed reduced production of two proteins important for neuron - to - neuron communication at synapses: synaptophysin and a glutamate receptor protein.

Unexpectedly, the patient - derived cells showed reduced production of FMRP, a protein that is associated with Fragile X syndrome, a common genetic cause of ASD and intellectual disability.

This increases production of the protective protein Annexin - A1, reduces production of inflammatory cytokines and restores normal cell function.

Researchers applied the findings to a mouse model with a genetic mutation in a component of the ribosome — the machinery that makes proteins — and the rate of protein production was reduced in stem cells by 30 percent.

Activation of the UPR induces the production of a family of basic leucine zipper - containing transcription factors that activate transcription of genes encoding functions to reduce the protein - folding load and increase the protein folding capacity of the ER.

In the study, which was published online today in the Annals of Neurology, the scientists reduced the level of the protein tau by genetically engineering Dravet mouse models, «knocking out» the gene associated with tau production.

One very effective way to «deal» with free oxygen is the production of «oxygen reductases»: proteins that reduce oxygen to water, and simultaneously conserve the energy inherent in this chemical reaction.

In July 2015, the most exciting drug trial so far in Huntington's disease began - one in which an ASO designed to reduce production of huntingtin protein was actually delivered to people with HD.

The trial was designed to test the safety of the drug and whether or not the drug could do what it was designed to do - reduce the production of the huntingtin protein.

Kennedy is interested in understanding why reduced gene expression in ribosomes enhances longevity in yeast and worms — ribosomes are tiny organelles that occur within the cell and are involved in the production of proteins.

One possible implication of this work is for so - called «gene - silencing» therapies for Huntington's disease, which aim to reduce production of the huntingtin protein, by sticking to its RNA message molecules and telling cells to get rid of them.

The endocannabinoid system regulates energy homeostasis through G protein — coupled cannabinoid - 1 receptors5, 6 located in the central nervous system and in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorders.

Besides being a major contributor to the growth and repair of tissues all around the body, vitamin C supports protein metabolism and helps keep testosterone levels high by reducing cortisol production, while vitamin E plays an important role in preventing muscle loss and glycogen storage.

Including protein foods throughout the day means your body will burn more calories simply by the work it takes to digest the protein you consume, encourage more fat loss via hormone production, which increases the integrity of your lean muscles, and even reduces cardiovascular risk!

1) Phytonutrients: * Occur naturally in fruits and vegetables * Promote the function of the immune system * Help fight off viruses as well as reduce inflammation * Associated with the treatment and / or prevention of cancer and cardiovascular disease 2) Enzymes: * Responsible for metabolic processes that occur within a cell and are necessary for sustaining life * Assist and play a large role in digestion, energy production, blood coagulation and contraction of muscles 3) Amino Acids: * The basic building blocks of protein * Absorption of amino acids is essential for your metabolism 4) Essential Fatty Acids: * Reduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones andreduce inflammation * Associated with the treatment and / or prevention of cancer and cardiovascular disease 2) Enzymes: * Responsible for metabolic processes that occur within a cell and are necessary for sustaining life * Assist and play a large role in digestion, energy production, blood coagulation and contraction of muscles 3) Amino Acids: * The basic building blocks of protein * Absorption of amino acids is essential for your metabolism 4) Essential Fatty Acids: * Reduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones andReduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones and teeth

A recent study coming from the Netherlands suggests that whey protein consumption can help you significantly improve your mood, eliminate symptoms of depression and reverse immunosuppression by simultaneously reducing the levels of cortisol and increasing the production of serotonin.

Pterostilbene also increases activity of the AMPK (adenosine monophosphate - activated protein kinase) pathway, which regulates production of energy, reduces chronic inflammation, lowers levels of blood sugar and fats in the blood, and reduces stores of body fat.

It's the caffeine that reduces appetite so not only aren't you getting the protein you need in the morning, but you likely won't eat enough throughout the rest of the day either which further impacts serotonin and melatonin production in a negative way.

Another study [13] found that obese women on a protein sparing modified fast (high protein, low - fat, low - carb, low - calorie) who took a teaspoon of baking soda had increased ketone production and reduced acidosis.

According to Dr. Barry Sears, developer of the Zone Diet, protein can help reduce cortisol production because protein doesn't significantly increase blood sugar levels and induce insulin spikes, which is stressful for the body.

It also helps stimulate saliva secretion, which increases the production of digestive juices, responsible for breaking down proteins, increasing digestibility and reducing the possibility of heartburn and other gastrointestinal issues.

Vitamin A also reduces your production of keratin, the protein that clumps your dead skin cells together into pore - blocking, acne causing blobs.

[5] Other studies have shown that vitamin C can reduce damage to the skin's protein fibers, increase the production of collagen and even reverse some age - related structural changes in the skin.

A reduction in animal protein reduces the production of acids within the body and appears to limit the excretion of urate — uric acid crystals that can act as seeds to form calcium stones or create entire stones themselves.

The reason a reduction in animal protein helps is not only because it reduces the production of acids within the body.

Also: «The reason a reduction in animal protein helps is not only because it reduces the production of acids within the body.

«It is possible in very low - carb diets, especially if protein intake is limited, to significantly reduce mucus production and impair the integrity of the gut mucosa and barrier.»

This classical diet is based on a ratio of ketone producing foods in the diet (fat) to foods that reduce ketone production (carbohydrate and protein).

When FOX03 is activated, it produces proteins that reduce inflammation, increase anti-oxidant production, repair DNA, and increase cellular energy production through the creation of new mitochondria.

So, the difference in plant and animal - based foods must be either due to a lower percentage of protein, which might reduce IGF - 1 production, or due to some accompanying factor in the food such as sterols in animal products vs. phytosterols in plants, which have a different chemical structure such as their extra ethyl group on their side - chain.

The negative effects seem to lie in the capacity of some foods / nutrients to stimulate proliferative pathways that in turn stimulate development of acne — suspect foods include those with a high glycaemic load and milk.11, 43, 44 Other evidence comes from several studies reporting that the prevalence of acne varies significantly between different populations and is substantially lower in non-Westernized populations that follow traditional diets, 45 a common factor among these traditional diets being a low glycaemic load.46 Various studies have provided evidence that high - glycaemic - load diets are implicated in the aetiology of acne through their capacity to stimulate insulin, androgen bioavailability and insulin - like growth factor - 1 (IGF - 1) activity, whereas the beneficial effects of low - glycaemic - load diets, apart from weight and blood glucose levels, also include improved skin quality.44 The clinical and experimental evidence does in fact suggest ways in which insulin can increase androgen production and affect via induction of steroidogenic enzymes, 47 the secretion by the pituitary gland of gonadotropin - releasing hormone and the production of sex hormone - binding globulin.48 Insulin is also able to reduce serum levels of IGF - binding protein - 1 increasing the effect of IGF - 1.49 These insulin - mediated actions can therefore influence diverse factors that underlie the development of acne such as:

In previous work, researchers developed mice with a mutation that reduces the animals» production of a protein called C / EBPβ - LIP.

Within cells, insulin promotes anabolism, such as the production of glycogen, fatty acids, and proteins, and counters catabolic events to reduce gluconeogenesis and inhibit fat and glycogen breakdown.

Restricted levels of highly digestible protein reduces demand on the kidneys and minimizes production of nitrogenous waste.

Causes include pancreatitis or idiopathic pancreatic acinar atrophy, where the production of enzymes responsible for fat, protein and starch digestion is reduced.

Reduced production of important blood proteins, which is worsened if the dog has an underlying condition that also causes liver failure or chronic gastrointestinal inflammation.

Lactulose, a non-metabolizable disaccharide, acidifies colonic contents (causing ammonia trapping), shortens the intestinal transit time, alters colonic flora, promotes incorporation of ammonia into bacterial proteins, and reduces production of potentially toxic short - chain fatty acids (SCFA) by producing the nontoxic SCFA acetate.

Urate Low purine proteins combined with the production of alkaline urine help reduce the risk of urate stones.

Kidney Disease: In pets with kidney problems, fish oil may lower elevated blood pressure, decrease undesired protein loss in urine, and reduce the production of pro-inflammatory substances that aggravate kidneys.