New drugs should be developed to have neuroprotection properties via the improvement of
synaptic plasticity,
reduced oxidant and inflammation damage, or rescue mobility dysfunctions.
Discovered that the persistent sodium current, INaP, paradoxically amplifies afterhyperpolarizations and
reduces the frequency (f / I) gain, and strongly modulates spike timing (Vervaeke et al., Neuron 2006); that Kv7 / M / KCNQ - type K + channels but not SK channels are essential for excitability control in hippocampal neurons (Gu et al., J Physiol, 2005); that Kv7 / M / KCNQ - type K + channels are essential for spatial learning and prevention of epilepsy (Nature Neuroscience 8: 51 - 60, 2005), that KCa1 / BK - type K + channels are essential for cerebellar learning and motor control (Proc Natl Acad Sci USA 101: 0474 - 8, 2004), the role of postsynaptic voltage-gated K + channels in regulation of
synaptic plasticity (LTP) and integration (Proc Natl Acad Sci USA 99:10144, 2002); that Kv7 / M / KCNQ - type K + channels are essential for intrinsic theta resonance in hippocampal neurons (J Physiol 545:783, 2002).
These compounds are found in plant foods and they
reduce oxidative stress while improving «
synaptic plasticity» — which makes you mentally sharper and promotes... Read More»