Mucke and his team have already demonstrated that lowering overall tau levels by 50 to 75 percent
reduces cognitive deficits in mice and is well tolerated.
LA JOLLA — Salk scientists have found further evidence that a natural compound in strawberries
reduces cognitive deficits and inflammation associated with aging in mice.
Studies in mice showed that the treatment appeared to
reduce the cognitive deficits associated with Angelman syndrome.
Not exact matches
Mandating such a limit would dramatically
reduce total head trauma, including the accumulation of sub-concussive hits that researchers at Purdue in a 2010 study found can lead to subtle
cognitive deficits that evade detection via the usual signs or symptoms method.
«Childhood aggression linked to
deficits in executive function: Primary school children with
reduced cognitive skills for planning and self - restraint are more likely to show increased aggression in middle childhood.»
This work suggests that
cognitive deficits may be a result of
reduced efficiency in brain - network communications.»
We will explore whether the intravenous administration of the recombinant protein is able to
reduce Aβ accumulation in the mouse brain and prevent the
cognitive and behavioral
deficits associated with that pathology.
The rationale behind the project is that acetylcholine plays are role in
cognitive functioning and that there is a subgroup of schizophrenia patients that have
reduced density and M1 receptor binding in the hippocampus and dorsolateral prefrontal cortex that are referred to as «muscarinic receptor -
deficit schizophrenia» or MRDS.
For example, he discovered that
reducing levels of a protein called tau can prevent
cognitive deficits in animal models of the disease.
He also has shown that
reducing tau levels, or suppressing the abnormal excitability of these networks with drugs, can both
reduce cognitive and behavioral
deficits in animal models of Alzheimer's disease.
Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and
reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as
cognitive deficits [2, 3].
Even more, drinking coffee is associated with
reduced motor and
cognitive deficits in aging thanks to coffee's polyphenols and other bioactive compounds.
Improving overall cardiovascular health (such as
reducing blood pressure and cholesterol) will help to
reduce the risk of stroke, but in many cases, people suffer a stroke and are looking for ways to improve recovery and prevent lasting
cognitive deficits.
Overusing technology results in
reduced exposure to external environmental stimuli that aid with brain development, and can actually impair it, resulting in attention
deficit,
cognitive delays, impaired learning, increased impulsivity, and inability to self - regulate, i.e. more tantrums.
Furthermore, people with high levels of CU traits (psychopathic personality) have been shown to have three specific
cognitive and emotional
deficits; a poor conditioned fear response,
reduced ability to recognise fear, and
deficits in stimulus - reinforcement tasks (see Moul et al. [12] for a review).