Sentences with phrase «reducing cell mutations»

Not exact matches

Further investigations showed that the mutation causes reduced CTLA - 4 function, which led to increased infiltration of the intestinal mucosa by T - cells and therefore to chronic diarrhea.

When injected into mice engineered with a tau mutation that makes the protein clump abnormally in brain cells, triggering memory and motor problems, the antibodies reduced the clumping and improved the animals» behavior.

To determine the effect of mutations that reduce TET2 function in abnormal stem cells, the research team genetically engineered mice such that the scientists could switch the TET2 gene on or off.

Xinde Zheng, a research associate in the Hunter lab, was already studying the properties of cells affected by Leigh syndrome, whose inherited neurodegeneration is caused by a mutation in mitochondrial DNA that reduces ATP production.

The removal of BRCA1 from the cells, which simulated what could happen in the cells of a person with a BRCA1 mutation, resulted in increased lipid storage, decreased insulin signaling, reduced mitochondrial function and increased oxidative stress.

They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

By performing DNA sequencing of more than 4,000 families affected by neurological problems, the two research teams independently discovered that a disease marked by reduced brain size and sensory and motor defects is caused by a mutation in a gene called CLP1, which is known to regulate tRNA metabolism in cells.

Scientists believe one of the ways the C9ORF72 mutation may cause ALS and FTD is by reducing the amount of C9orf72 protein present in the cells — something which is very hard to verify without a clear understanding of the function of the C9orf72 protein.

Researchers applied the findings to a mouse model with a genetic mutation in a component of the ribosome — the machinery that makes proteins — and the rate of protein production was reduced in stem cells by 30 percent.

These approaches, which include exotic sounding tools like zinc finger nucleases and CRISPR / Cas9, differ from more traditional ways reducing the impact of the HD mutation on cells.

Mutations in the gene increase rat susceptibility to mammary cancer and FRY reduced the growth of highly aggressive human breast cancer cells.

Recent work from Fousteri Lab revealed a novel metabolic function of active transcription that is rapidly switched on globally in human cells to promote genetic accuracy, and reduce the mutation burden in genotoxins - exposed tissues, such as skin and lung, thus actively participating in lowering oncogenesis.

Understanding the processes that restrain mutant cells from developing into tumours, and how they are breached when cancers do form will guide the development of strategies to reduce the chance of cancer development in individuals who have acquired a high level of mutations.

Loss - of - Function Mutation of Reduced Wall Acetylation 2 in Arabidopsis Leads to Reduced Cell Wall Acetylation and Increased Resistance to Botrytis cinerea, Yuzuki Manabe, Majse Nafisi, Yves Verhertbruggen, Caroline Orfila, Sascha Gille, Carsten Rautengarten, Candice Cherk, Susan Marcus, Shauna Somerville, Markus Pauly, J. Paul Knox, Yumiko Sakuragi, Henrik Scheller, Plant Physiology, 155 (3), 1068 - 1078, doi: 10.1104 / pp. 110.168989, March 2011.

In line with these observations, all F958 - and P960 - targeting JAK1 mutations showed reduced inhibition of STAT5 phosphorylation in response to CMP6, while all the other mutations had similar IC50 to that of the parental BaF3 cells growing in the presence of IL - 3 (data not shown).

Both antioxidant compounds work reducing the proliferation of reactive oxygen species in cells, preventing mutations and dead due to oxidative stress.

Ellagic acid is a hunter of cancerigenous chemicals, inactivating them, impeding the capacity of other chemicals to trigger abnormal mutations into pathogens Moreover, Ellagic Acid from meeker red raspberries inhibits binding of carcer causing material to DNA, reducing the extent of the condition in cultured cells vulnerable to carcinogens.

In one study, vitamin C reduced cancer - causing mutations in mice; in another, it was found to kill up to 50 percent of human lymphoma cells.

It also reduces damage to cell DNA, mitigating the risk of potential cancer - causing mutations.

Early spaying may therefore, reduce occurrence of malignant lesions because the procedure removes the source of the hormones that cause some mammary cells to lose growth control, which puts these dividing cells at high risk for mutation and malignant transformation by environmental carcinogens.In fact, recent reports have identified activation of a specific oncogene in a number of canine mammary tumors.