Sentences with phrase «reducing gene activity»

Borrelli said they observed a remarkable decrease in expression levels of some 2,000 genes in this area, coupled with a widespread increase in modifications of basic DNA proteins called histones — particularly those associated with reduced gene activity.

The initial results published last year showed that people who scored in the top 15 percent of the U.C.L.A. Loneliness Scale, a self - administered psychiatric questionnaire for measuring the emotion, exhibited increased gene activity linked to inflammation and reduced gene activity associated with antibody production and antiviral responses.

Not exact matches

The activity of genes involved in cholesterol production in the hypothalamus — an area involved in the brain's energy maintenance — was reduced by 25 per cent in both groups of diabetic mice.

«People with this gene mutation usually get Alzheimer's at around age 70 because of the buildup of amyloids due to the reduced activity of the protective enzyme,» says Tanzi.

«The elephant results revealed noncoding sequences in the human genome that we predict may control gene activity and reduce the formation of mutations and cancer.»

Depth horizons with functional genes indicative of methane - cycling and sulfate - reducing microorganisms are enriched in solid - phase sulfur and total organic carbon, host δ13C - and δ34S - isotopic values with a biological imprint, and show clear signs of microbial activity when incubated in the laboratory.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

A single injection of a new treatment has reduced the activity of the gene responsible for Huntington's disease for several months in a trial in mice.

Dr. Je and his team analysed signalling activity in neuronal cultures that either did not have the DTNBP1 gene or had lowered levels of the gene, because reduced DTNBP1 levels and genetic disruptions of DTNBP1 in mice resulted in schizophrenia - like behaviours.

The group took the first step toward their goal of a novel engineering strategy for yeast by creating what is known as a cDNA library: a collection of over 90 % of the genes from the genome of baker's yeast (Saccharomyces cerevisiae), arranged within a custom segment of DNA so that each gene will be, in one version, overactive within a yeast cell, and in a second version, reduced in activity.

They assessed gene activity at time points known to correspond with key phases of disease: the «induction phase,» the time before the peak level of photoreceptor cell death; the «execution phase,» when the highest rates of photoreceptor cell death occur; and the «chronic phase,» during which photoreceptor cell death continues at somewhat reduced levels.

Both teams» zinc finger drugs did the job of reducing the activity of genes containing long CAG stretches.

Activity of the mutant huntingtin gene was reduced by around 50 % in the brain near the injection site.

Reducing the activity of the mitochondria - associated gene clk - 1 - lowering the amount of protein generated from its blueprint in other words - boosts mouse longevity by 30 % or so.

Interestingly, when we knocked down these two genes or reduced TOR activity specifically in the fat body, both total AKT and pAKT levels were reduced.

Reduced expression of Paternally Expressed Gene - 3 enhances somatic cell reprogramming through mitochondrial activity perturbation, Scientific Reports.

These suppressor genes are inactivated in tumors, and since cancer drugs work by reducing the activity of enzymes, they won't work on such suppressors because a drug can't inhibit a gene that is already inactivated.»

In a series of electrophysiological studies, Zoghbi's team further found that neurons from animals with depleted MECP2 levels have reduced electrical activity due to a smaller number of excitatory synapses, whereas cells from animals carrying an extra copy of the gene have increased electrical activity because of an increase in synapse number.

COMT enzyme activity is reduced by this gene by 3 to 4 times.

«Skeletal muscle from animals randomized to PMI 5011 was demonstrated to have decreased 20S proteasome activity and reduced gene expression of specific proteins as part of the ubiquitin — proteasome system in skeletal muscle», they write.

However, the good news is that according to the 2011 study even moderate physical activity such as walking is able to reduce the negative influence of this obesity - related gene variation by more than 25 %!

It's also high in tomatidine, which has been shown to boost muscle mass in mice by reducing the activity of a gene called ATF4, known for inhibiting muscle protein synthesis.

Studies showed that curcumin reduced joint swelling by modifying gene expression; inhibited inflammation by regulating NF - κB, a pro-inflammatory protein; and slowed down joint destruction by decreasing activity of osteoblasts, cells involved in bone breakdown.