Sentences with phrase «reductase as»

This is partially due to an increased activity of an enzyme known as 5 - alpha reductase as men age.

This is because saw palmetto works best by inhibiting 5 - alpha - reductase as opposed to stopping the activities of DHT.

Not exact matches

As we noted Saturday, Endo hit upon a fungus four decades ago that inhibited the production of reductase, an enzyme that helps synthesize heart - clogging cholesterol.

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptors.

They zoomed in on the action within the enzyme, known as methyl - coenzyme M reductase.

Twelve percent encoded mitochondrial proteins such as succinate dehydrogenase complex, subunit B, iron sulfur (Ip)(τ statistic = — 0.76, P = 2.2 × 10 — 7), and ubiquinol — cytochrome c reductase subunit (τ statistic = — 0.65, P = 7.4 × 10 — 6)(Figure 1), and 6 % encoded lysosomal proteins (Supplemental Table 2, http://www.jci.org/cgi/content/full/112/12/1796/DC1).

Super-complexes, able to specifically perform linear or cyclic photosynthetic electron flow have been identified, and all contain the enzyme ferredoxin NADP + reductase (FNR), which is also present as a soluble protein.

Using cell culture and laboratory mouse experiments, the researchers showed that the enzyme, aldose reductase, is essential to a process known as goblet cell metaplasia that is seen in both asthma and COPD.

Researchers have proved that a single «master switch» enzyme, known as aldose reductase, is key in producing excess mucous that clogs the airways of people with asthma and chronic obstructive pulmonary disease (COPD).

The next step, Srivastava said, is clinical trials of the drugs as a therapy for asthma and COPD — a process that should be expedited since aldose reductase inhibitors have already undergone Phase III clinical trials for diabetic neuropathy.

Failure to accumulate upstream biosynthetic intermediates has also been shown in the Arabidopsis BR - deficient dwarf5 mutant, defective in the delta - 7 sterol reductase (Choe et al., 2000), as well as the dwarf br6 - oxidase double mutants, which had lower 24 - methylene cholesterol (Kwon et al., 2005).

«Aldose reductase is key to a whole range of inflammation disorders, so it comes as no surprise that it should be crucial to the inflammatory processes that drive disease in asthma and COPD,» said UTMB Health biochemistry and molecular biology professor Satish Srivastava, senior author of the paper.

One of the first enzymes is 3 - hydroxy -3-methylglutaryl-CoA reductase, also known as HMGCR, the main target of statins.

High temperatures and an altered redox environment may compromise the quality of MAbs produced (e.g., fragmentation, truncation), as can the presence of proteases, reductases, and other chemicals released from dead cells.

It increases the enzyme 5 - alpha reductase which, as we mentioned earlier, raises your DHT levels.

It's also known to act as a 5 - alpha reductase inhibitor.

Pygeum and nettle root extracts have a positive impact on the prostate gland in that it serves as a prevention against benign prostatic hyperplasia, by blocking the enzyme 5 - alpha reductase.

Possible Interactions Certain medications such as Adriamycin, lovastatin and other HMG CoA - reductase inhibitors, gemfibrozil, beta - blockers, tricyclic antidepressants, and phenothiazine may deplete the body of coenzyme Q10.

This complex synthesis involves 37 steps and starts with a key enzyme known as HMG - CoA reductase (inhibited by statins, a class of cholesterol - lowering drugs).

Synthesis and biological activity of progesterone derivatives as 5alpha - reductase inhibitors, and their effect on hamster prostate weight..

Aromatic esters of progesterone as 5alpha - reductase and prostate growth inhibitors..

Low levels of 5α - DHT are indicative of over-inhibition of 5α - reductase (5AR), the enzyme that converts testosterone to 5α - DHT, which is ~ 2 - 3 times as potent as testosterone due to 5α - DHT's greater affinity for androgen receptors.15

This resulted in a higher absolute number of aggressive prostate cancers in the dutasteride group than in the placebo group — even though the placebo group had a higher rate of prostate cancer.145 (See above «Mechanisms through which 5α - reductase inhibitors promote prostate cancer»)(Neal, please make this a link to this section above) Thus, as we have seen elsewhere, e.g., rofecoxib (Vioxx ®), celecoxib (Celebrex ®), balance in biological processes is more beneficial than absolute interruption.)

However, if androsterone is low in relation to etiocholanolone in men, then 5α - reductase activity may be low as well, leaving more testosterone to be aromatized to estradiol.

Several possible mechanisms could explain why: (1) Since 5α - DHT is ~ 3x as potent as testosterone, 5α - reductase activity may be increased to compensate for the low testosterone levels pre-treatment.

When applied as a whole, E. Cava was shown to inhibit 5 - alpha - reductase up to 61.5 %.

The primary treatment for LUTS, BPH and CP in conventional medicine involves the use of alpha - adrenergic antagonist drugs (such as Flomax) and 5 - alpha - reductase inhibitor drugs.

Aldose reductase is the first enzyme in the sorbitol - aldose reductase (polyol) pathway [12] responsible for the reduction of glucose to sorbitol, as well as the reduction of galactose to galactitol.

When blood glucose is normal (about 100 mg / dl or 5.5 mmol / l), this interchange causes no problems, as aldose reductase has a low affinity for glucose at normal concentrations.

Modern research reveals that red yeast rice contains number of compounds that act as natural HMG - CoA reductase inhibitors, similar to the cholesterol - lowering ingredient found in pharmaceutical statin drugs.

In the scalp, in acidic conditions, the 5 - alpha reductase can much more easily convert testosterone into the hormone DHT — which is well known as the hormone that is responsible for pattern baldness.

Furthermore, green tea activates enzymes such as quinone reductase and glutathione, both of which have detoxification properties.

They fall under the drug category known as «HMG - CoA reductase inhibitors», meaning that they block the action of this enzyme in the body.

According to this study, chlorophyll can increase the activity of the phase 2 detoxification enzyme known as quinone reductase.

As a 5 - alpha reductase inhibitor, it stops testosterone from being converted into DHT.

If the evidence stopped here, it would be promising for acne, as 5 - alpha reductase manufactures all DHT in the body via conversion from testosterone.

These HMG - CoA reductase inhibitors, called statins, are sold as Lipitor, Mevacor, Pravacol, Zocor, etc..

As for DHT, it should still fall even if total 5 - alpha reductase has increased.

The DHT conversion from testosterone is facilitated by an enzyme known as 5 - alpha - reductase (5 - AR).

This conversion happens as men get older, and is catalyzed by an enzyme called 5 - alpha reductase.

Statins such as Lipitor, Zocor, Pavacol and Mevacor lower cholesterol by inhibiting HMG - CoA reductase, a key enzyme in cholesterol synthesis.

Notably, the 5α - reductase inhibiting properties of a close plant relative of turmeric, Curcuma aeruginosa, appear to work as well as minoxidil in helping to regrow hair.

For sufferers of hair loss, it is especially interesting due to its nature as a 5 - alpha reductase inhibitor, meaning it has the same effect on alopecia as the synthetic drug finasteride, yet it isn't associated with the negative side effects of that drug.

As blood glucose levels increase, glucose also increases within the aqueous humor, glucose readily diffuses across the lens capsule, an aldose reductase pathway converts glucose to sorbitol, sorbitol accumulates within the lens as it can not diffuse through lens cell membranes, the osmotic gradient increases, water enters the lens and irreversibly changes the lens structure via lens fiber swelling and rupture, vacuole formation, and clinically evident cataracAs blood glucose levels increase, glucose also increases within the aqueous humor, glucose readily diffuses across the lens capsule, an aldose reductase pathway converts glucose to sorbitol, sorbitol accumulates within the lens as it can not diffuse through lens cell membranes, the osmotic gradient increases, water enters the lens and irreversibly changes the lens structure via lens fiber swelling and rupture, vacuole formation, and clinically evident cataracas it can not diffuse through lens cell membranes, the osmotic gradient increases, water enters the lens and irreversibly changes the lens structure via lens fiber swelling and rupture, vacuole formation, and clinically evident cataract.

10); plant growth is slower under elevated than ambient CO2 when NO3 serves as the sole N source and faster when NH4 C serves as the sole N source (5,12); deltaAQ (changes in the ratio of net CO2 consumption to net O2 evolution after shifting N nutrition from NH4 + to NO3 --RRB-, a real - time measure of leaf NO3 assimilation, decreases with increasing leaf internal CO2 concentration (9,12); and maximum NO3 reductase activity in vitro is usually less under elevated than ambient CO2 (refs.

I am trying to disentangle hormone / hormone receptor effects, this bit is made as simple as possible; Test - > E2 (Aromatase) Test - > DHT (5α - reductase) DHT - > 3,17 diol (three known enzymes) E2 is a agonist to ERa, ERb1 to Erb5; Tissue specific distribution.