Sentences with phrase «reductase in»

They also inhibit the cholesterol - producing enzyme HMG - CoA reductase in the liver, which lowers LDL, and in other cells (including the brain) which can produce both benefits and harms (for example, this enzyme is also needed to make vitamin K2, which is important for sulfatide synthesis in the brain and hence cognition).

This condition is particularly important for women because it increases an enzyme called 5 - alpha reductase in your body.

Cutting Edge: Induction of the Antigen - Processing Enzyme IFN --LCB- gamma -RCB-- Inducible Lysosomal Thiol Reductase in Melanoma Cells Is STAT1 - Dependent but CIITA - Independent

«Targeted Protein Degradation of Outer Membrane Decaheme Cytochrome MtrC Metal Reductase in Shewanella oneidensis MR - 1 Measured Using Biarsenical Probe CrAsH - EDT2.»

Isoprenoid - mediated suppression of HMG CoA reductase in tumors was previously correlated to growth arrest; the latter was attenuated by supplemental mevalonate.

Expression of nitrite and nitric oxide reductases in free - living and plant - associated Agrobacterium tumefaciens C58 cells.

Not exact matches

Infants in this age range are vulnerable because they have not matured enough to produce methemoglobin reductase, an oxygen - carrying molecule.

Returning to Japan, he happened upon a compound in a fermented broth of Penicillium citrinum, a rice mold taken from a shop in Kyoto, that blocked the action of HMG - CoA reductase.

More than 30 different enzymes orchestrate the process, but one central to the assembly line is called 3 - hydroxy -3-methylglutaryl-CoA (or HMG - CoA) reductase, an early step in a long line of steps.

HMG - CoA (3 - hydroxy -3-methylglutaryl — coenzyme A) reductase (HMGR) catalyzes the committed step in cholesterol biosynthesis.

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptorIn collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptorin Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptorin the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptors.

In June researchers at the University of California at Berkeley published a study showing that in yeast, the vitamin folate can remedy impaired activity of an important enzyme, methylenetetrahydrofolate reductasIn June researchers at the University of California at Berkeley published a study showing that in yeast, the vitamin folate can remedy impaired activity of an important enzyme, methylenetetrahydrofolate reductasin yeast, the vitamin folate can remedy impaired activity of an important enzyme, methylenetetrahydrofolate reductase.

They zoomed in on the action within the enzyme, known as methyl - coenzyme M reductase.

But other lipids are known to guide cell migrations in human brain development, and geneticist Ken Howard of University College London suspects HMG - CoA reductase might help produce a similar lipid molecule or modify a protein that attracts the germ cells.

This structure is in complex with an oxido - reductase β subunit of the kind that can regulate mammalian Kv channels in their native cell environment.

3NOP inhibits methyl coenzyme - M reductase, an enzyme used by bacteria in a cow's gut.

We found that genes encoding subunits of the Mg - chelatase complex and 3,8 - divinyl protochlorophyllide a 8 - vinyl reductase (DVR) likely function directly downstream of the GATAs and that DVR expression is limiting in the pale - green gnc gnl mutants.

One such protein was methyl - coenzyme M reductase, which is involved in transforming carbon dioxide into methane.

«The discovery that aldose reductase regulates mucus production and goblet cell metaplasia makes inhibition of this enzyme an attractive therapeutic option to reduce mucus - related airway obstructive diseases — and for the first time gives us a real chance to alter the course of the underlying disease in asthma and COPD.»

Löffler, J., Trojovsky, A., Casati, B., Kroisel, P.M. & Utermann, G. Homozygosity for the W151X stop mutation in the δ7 - sterol reductase gene (DHCR7) causing a lethal form of Smith - Lemli - Opitz syndrome: retrospective molecular diagnosis.

Using cell culture and laboratory mouse experiments, the researchers showed that the enzyme, aldose reductase, is essential to a process known as goblet cell metaplasia that is seen in both asthma and COPD.

Researchers have proved that a single «master switch» enzyme, known as aldose reductase, is key in producing excess mucous that clogs the airways of people with asthma and chronic obstructive pulmonary disease (COPD).

Failure to accumulate upstream biosynthetic intermediates has also been shown in the Arabidopsis BR - deficient dwarf5 mutant, defective in the delta - 7 sterol reductase (Choe et al., 2000), as well as the dwarf br6 - oxidase double mutants, which had lower 24 - methylene cholesterol (Kwon et al., 2005).

«Aldose reductase is key to a whole range of inflammation disorders, so it comes as no surprise that it should be crucial to the inflammatory processes that drive disease in asthma and COPD,» said UTMB Health biochemistry and molecular biology professor Satish Srivastava, senior author of the paper.

Lesions in the sterol delta reductase gene of Arabidopsis cause dwarfism due to a block in brassinosteroid biosynthesis

An anticancer agent, pyrvinium pamoate inhibits the NADH - fumarate reductase system - a unique mitochondrial energy metabolism in tumour microenvironments.

Massive SVC Thrombus in a Woman With Heterozygous Methyl - Tetrahydrofolate Reductase A1298C Genetic Mutation

Reporting the first association between genetic variants in the human steroid 5a - reductase type II (encoded by the SRD5A2 gene) and prostate cancer in 1999.

He identified and characterized significant biochemical and pharmacogenetic variation in human steroid 5a - reductase type II (encoded by the SRD5A2 gene) in 2000.

Background: Treatment with HMG - CoA reductase inhibitors («statins») has been variably associated with a reduced risk of Alzheimer's disease (AD) in epidemiologic studies and reduced amyloid - β (Aβ) deposition in animal models of AD.

He also discovered common somatic mutations in prostate cancer in the human steroid 5a - reductase type II (SRD5A2) gene in 2004.

In recent years, Michel and his research group mainly studied two types of oxygen reductases: the so - called superfamily of «heme - copper oxidases», and the «cytochrome bd oxidase».

For more than the last ten years, Hartmut Michel has studied different oxygen reductases at the Max Planck Institute of Biophysics in Frankfurt, where he became director in 1987.

One very effective way to «deal» with free oxygen is the production of «oxygen reductases»: proteins that reduce oxygen to water, and simultaneously conserve the energy inherent in this chemical reaction.

Abstract: Background: Treatment with HMG - CoA reductase inhibitors («statins») has been variably associated with a reduced risk of Alzheimer's disease (AD) in epidemiologic studies and reduced amyloid - β (Aβ) deposition in animal models of AD.

Upstream ORFs and ATF4 - binding sites are found in many genes, but for the purposes of this review genes that carry out biosynthesis of non-essential amino acids (ASNS, alanine aminotransferase 2, PSAT, serine hydroxymethyltransferase 2, pyrroline -5-carboxylate reductase and glutamate - oxaloacetate transaminase) and genes encoding amino acid transporters (cat1, ASCT1, ASCT2, SNAT2, SNAT7, LAT1, EAAT5 and xCT) are notably abundant [83,120].

Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids.

It works by interfering with vitamin K epoxide reductase, an enzyme involved in the blood clotting process.

The methylenetetrahydrofolate reductase (MTHFR) gene produces the MTHFR enzyme, which is responsible for breaking down (methylating) folate in the body.

Pygeum and nettle root extracts have a positive impact on the prostate gland in that it serves as a prevention against benign prostatic hyperplasia, by blocking the enzyme 5 - alpha reductase.

The blood glucose, plasma insulin, hemoglobin, glycated hemoglobin, activities of the various antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase) and lipid peroxidation markers (malondialdehyde, hydroperoxides and conjugated dienes) were evaluated in all the groups.

Magnesium deficiency is correlated with reduced Cytochrome P450 and NADH cytochrome reductase enzymes which plays a vital role in phase I liver biotransformation.

(2) Unlike natural folates, which are metabolized to THF in the mucosa of the small intestine, folic acid undergoes initial reduction and methylation in the liver, where conversion to the THF form requires dihydrofolate reductase.

The 7 - dehydrocholesterol reductase enzyme (7 - DHCR), which is responsible for converting 7 - dehydrocholesterol into cholesterol, possesses a specific component that is able to sense the presence of cholesterol and other sterols and may reduce its activity when the pool of cholesterol or its precursors is depleted.21 If this is the case, the pool of 7 - dehydrocholesterol could be preserved even in the face of decreasing mevalonate.

Since progesterone is crucial for testosterone production, progesterone therapy side effects rarely occur in males who also require this hormone to prevent the production of 5 - alpha reductase, another enzyme that converts testosterone — this time into dihydrotestosterone (DHT).

These medications are able to block the action of an enzyme called HMG CoA reductase (7,11) that is necessary for making cholesterol in the liver.

In women, elevated 5α - reductase activity is linked to acne, hirsutism, hair loss, hypothyroidism, PCOS, insulin resistance, and obesity.

Thus, in women, elevated 5α - reductase may contribute to PCOS.

Elevated 5α - reductase activity associated w / PCOS, hirsutism, obesity, insulin resistance in women

Competitive Inhibitors of HMG - CoA Reductase, aka «Statins» «Statins» block a key step in the formation of cholesterol.