Alpha -
reductase Type 2 is present around the hair follicles, resulting in male pattern baldness and hirsutism.
He also discovered common somatic mutations in prostate cancer in the human steroid 5a -
reductase type II (SRD5A2) gene in 2004.
He identified and characterized significant biochemical and pharmacogenetic variation in human steroid 5a -
reductase type II (encoded by the SRD5A2 gene) in 2000.
Reporting the first association between genetic variants in the human steroid 5a -
reductase type II (encoded by the SRD5A2 gene) and prostate cancer in 1999.
Not exact matches
In recent years, Michel and his research group mainly studied two
types of oxygen
reductases: the so - called superfamily of «heme - copper oxidases», and the «cytochrome bd oxidase».
At Scripps, Crane studied metalloenzymes and applied structural biology techniques to trying to understand the catalytic mechanisms of two
types of redox enzymes, sulfite
reductases and nitric oxide synthases.
The optimum pH range for
type 2 5 - alpha -
reductase is pH 5 - 5.5.
In fact, about 5 — 10 % of circulating free testosterone, with the help of the enzyme
Type II 5 - alpha
reductase, converts to DHT.
In men and women, testosterone is converted to DHT via an enzyme called
Type II 5 - alpha
reductase.
Lab studies show that whole turmeric extracts inhibit
type II 5α -
reductase enzymes.
Both
types of the 5 Alpha -
reductase affect the conversion of testosterone to DHT.